Polygenic Score (PGS) ID: PGS012590

Predicted Trait
Reported Trait Alzheimer's disease (excluding the APOE region)
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: Sept. 17, 2026
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Score Details

Score Construction
PGS Name PRS_AD
Development Method
Name weighted PRSsummation PRS-CSs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,070,111
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000824
Citation (link to publication) Kurniansyah N et al. Nat Genet (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 93.8%
African: 4.1%
East Asian: 2.1%
546,000 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • East Asian
  • South Asian
  • Hispanic or Latin American
  • Additional Diverse Ancestries
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90565439
Europe PMC: 40533518
 99,796 individuals European EADB, Other
GWAS Catalog: GCST90267625
Europe PMC: 36543923
 22,447 individuals African American or Afro-Caribbean MVP
Europe PMC: 39428694
[
  • 1,583 cases
  • , 1,957 controls
]
 East Asian
(Korean)		 GARD
412,181 individuals European FinnGen
8,036 individuals East Asian
(Japanese)		 NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030765 PSS012286|
Multi-ancestry (including European)|
26,874 individuals
 PGP000824 |
Kurniansyah N et al. Nat Genet (2026)
 Reported Trait: Alzheimer's disease OR: 1.39 [1.34, 1.44] AUROC: 0.78 — age, sex, APOE e4/e2 dosage, genetic ancestry and 10PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012286 — —
[
  • 10,610 cases
  • , 16,264 controls
]
,
62.0 % Male samples
 Mean = 73.16 years European, African unspecified, East Asian, South Asian, Hispanic or Latin American, Native American — ADSP —