PGS Publication: PGP000824

Publication Information (EuropePMC)
Title A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations.
PubMed ID 42661068(Europe PMC)
doi 10.1038/s41588-026-02722-8
Publication Date Aug. 27, 2026
Journal Nat Genet
Author(s) Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush WS, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GD, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA.
Released in PGS Catalog: Sept. 17, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012590
(PRS_AD)
 PGP000824 |
Kurniansyah N et al. Nat Genet (2026)
 Alzheimer's disease (excluding the APOE region) Alzheimer disease 1,070,111
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012590/ScoringFiles/PGS012590.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030765 PGS012590
(PRS_AD)
 PSS012286|
Multi-ancestry (including European)|
26,874 individuals
 PGP000824 |
Kurniansyah N et al. Nat Genet (2026)
 Reported Trait: Alzheimer's disease OR: 1.39 [1.34, 1.44] AUROC: 0.78 — age, sex, APOE e4/e2 dosage, genetic ancestry and 10PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012286 — —
[
  • 10,610 cases
  • , 16,264 controls
]
,
62.0 % Male samples
 Mean = 73.16 years European, African unspecified, East Asian, South Asian, Hispanic or Latin American, Native American — ADSP —