Polygenic Score (PGS) ID: PGS018409

Predicted Trait
Reported Trait Heart failure
Mapped Trait(s) heart failure (MONDO_0005252)
Additional Trait Information Multi-latent polygenic score: LASSO combination of the 49 cardiac-MRI latent PRS to predict heart failure.
Released in PGS Catalog: July 15, 2026
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Score Details

Score Construction
PGS Name MultiPRS_heart-failure
Development Method
Name LASSO (L1-penalised logistic regression)
Parameters LASSO combination of the 49 individual latent-phenotype PRS (scikit-learn LogisticRegressionCV, L1 penalty, saga solver, stratified 5-fold CV). The scoring file contains the collapsed per-variant weights of the genetic (PRS) component only; model covariates (age, sex, body surface area, 20 genetic PCs) are applied separately and are NOT part of the scoring file.
Variants
Original Genome Build GRCh37
Number of Variants 1,105,535
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000826
Citation (link to publication) Ometto S et al. Nat Commun (2026)
Ancestry Distribution
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

No sample information available.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036539 PSS012295|
European Ancestry|
2,553 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Prevalent Heart failure OR: 3.1 AUROC: 0.6913 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1328); DeLong p=0.183869673873534. Sex='Both' (male/female strata also in Suppl. Data 27).
PPM036540 PSS012296|
European Ancestry|
8,142 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Incident Heart failure (1-10 yr) HR: 0.96 [0.94, 0.97]
OR: 3.16		 AUROC: 0.6932 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=1.1508); HR per SD of PRS from Cox model (col D); DeLong p=0.6353568793886567. Sex='Both'.
PPM036541 PSS012297|
European Ancestry|
14,172 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Heart failure OR: 3.01 AUROC: 0.6836 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.102); DeLong p=0.7920128596259659. Sex='Both'.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012295 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 2,553 individuals — European — UKB —
PSS012296 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 8,142 individuals — European — UKB —
PSS012297 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 14,172 individuals — European — UKB —