| Publication Information (EuropePMC) | |
| Title | Hundreds of cardiac MRI traits derived using 3D diffusion autoencoders share a common genetic architecture. |
| PubMed ID | 42373625(Europe PMC) |
| doi | 10.1038/s41467-026-74575-y |
| Publication Date | June 29, 2026 |
| Journal | Nat Commun |
| Author(s) | Ometto S, Chatterjee S, Vergani AM, Landini A, Sharapov S, Giacopuzzi E, Visconti A, Bianchi E, Santonastaso F, Soda EM, Cisternino F, Pivato CA, Ieva F, Angelantonio ED, Pirastu N, Glastonbury CA. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS018360 (GWAS_disc_Z5_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z5_S5 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018360/ScoringFiles/PGS018360.txt.gz |
| PGS018374 (GWAS_disc_Z35_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z35_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018374/ScoringFiles/PGS018374.txt.gz |
| PGS018377 (GWAS_disc_Z44_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z44_S3 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018377/ScoringFiles/PGS018377.txt.gz |
| PGS018379 (GWAS_disc_Z51_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z51_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018379/ScoringFiles/PGS018379.txt.gz |
| PGS018380 (GWAS_disc_Z53_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z53_S1 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018380/ScoringFiles/PGS018380.txt.gz |
| PGS018395 (GWAS_disc_Z100_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z100_S3 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018395/ScoringFiles/PGS018395.txt.gz |
| PGS018359 (GWAS_disc_Z4_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z4_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018359/ScoringFiles/PGS018359.txt.gz |
| PGS018362 (GWAS_disc_Z10_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z10_S4 | magnetic resonance imaging of the heart | 1,105,487 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018362/ScoringFiles/PGS018362.txt.gz |
| PGS018363 (GWAS_disc_Z12_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z12_S4 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018363/ScoringFiles/PGS018363.txt.gz |
| PGS018364 (GWAS_disc_Z14_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z14_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018364/ScoringFiles/PGS018364.txt.gz |
| PGS018366 (GWAS_disc_Z22_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z22_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018366/ScoringFiles/PGS018366.txt.gz |
| PGS018413 (MultiPRS_type-2-diabetes) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Type 2 diabetes mellitus | type 2 diabetes mellitus | 1,105,536 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018413/ScoringFiles/PGS018413.txt.gz |
| PGS018371 (GWAS_disc_Z29_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z29_S1 | magnetic resonance imaging of the heart | 1,105,487 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018371/ScoringFiles/PGS018371.txt.gz |
| PGS018372 (GWAS_disc_Z31_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z31_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018372/ScoringFiles/PGS018372.txt.gz |
| PGS018373 (GWAS_disc_Z32_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z32_S1 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018373/ScoringFiles/PGS018373.txt.gz |
| PGS018376 (GWAS_disc_Z41_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z41_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018376/ScoringFiles/PGS018376.txt.gz |
| PGS018385 (GWAS_disc_Z82_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z82_S1 | magnetic resonance imaging of the heart | 1,105,490 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018385/ScoringFiles/PGS018385.txt.gz |
| PGS018387 (GWAS_disc_Z86_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z86_S3 | magnetic resonance imaging of the heart | 1,105,490 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018387/ScoringFiles/PGS018387.txt.gz |
| PGS018390 (GWAS_disc_Z92_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z92_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018390/ScoringFiles/PGS018390.txt.gz |
| PGS018392 (GWAS_disc_Z94_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z94_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018392/ScoringFiles/PGS018392.txt.gz |
| PGS018394 (GWAS_disc_Z97_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z97_S2 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018394/ScoringFiles/PGS018394.txt.gz |
| PGS018397 (GWAS_disc_Z106_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z106_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018397/ScoringFiles/PGS018397.txt.gz |
| PGS018398 (GWAS_disc_Z108_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z108_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018398/ScoringFiles/PGS018398.txt.gz |
| PGS018399 (GWAS_disc_Z111_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z111_S1 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018399/ScoringFiles/PGS018399.txt.gz |
| PGS018405 (GWAS_disc_Z127_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z127_S4 | magnetic resonance imaging of the heart | 1,105,484 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018405/ScoringFiles/PGS018405.txt.gz |
| PGS018406 (GWAS_disc_Z127_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z127_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018406/ScoringFiles/PGS018406.txt.gz |
| PGS018407 (MultiPRS_angina-pectoris) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Angina pectoris | angina pectoris | 1,105,536 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018407/ScoringFiles/PGS018407.txt.gz |
| PGS018408 (MultiPRS_coronary-heart-disease) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Coronary heart disease | coronary artery disorder | 1,105,536 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018408/ScoringFiles/PGS018408.txt.gz |
| PGS018381 (GWAS_disc_Z66_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z66_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018381/ScoringFiles/PGS018381.txt.gz |
| PGS018358 (GWAS_disc_Z1_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z1_S5 | magnetic resonance imaging of the heart | 1,105,487 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018358/ScoringFiles/PGS018358.txt.gz |
| PGS018361 (GWAS_disc_Z6_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z6_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018361/ScoringFiles/PGS018361.txt.gz |
| PGS018365 (GWAS_disc_Z20_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z20_S1 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018365/ScoringFiles/PGS018365.txt.gz |
| PGS018378 (GWAS_disc_Z49_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z49_S1 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018378/ScoringFiles/PGS018378.txt.gz |
| PGS018383 (GWAS_disc_Z78_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z78_S1 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018383/ScoringFiles/PGS018383.txt.gz |
| PGS018402 (GWAS_disc_Z118_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z118_S1 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018402/ScoringFiles/PGS018402.txt.gz |
| PGS018370 (GWAS_disc_Z28_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z28_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018370/ScoringFiles/PGS018370.txt.gz |
| PGS018375 (GWAS_disc_Z38_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z38_S5 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018375/ScoringFiles/PGS018375.txt.gz |
| PGS018384 (GWAS_disc_Z80_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z80_S1 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018384/ScoringFiles/PGS018384.txt.gz |
| PGS018386 (GWAS_disc_Z85_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z85_S5 | magnetic resonance imaging of the heart | 1,105,484 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018386/ScoringFiles/PGS018386.txt.gz |
| PGS018391 (GWAS_disc_Z93_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z93_S1 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018391/ScoringFiles/PGS018391.txt.gz |
| PGS018393 (GWAS_disc_Z95_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z95_S3 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018393/ScoringFiles/PGS018393.txt.gz |
| PGS018400 (GWAS_disc_Z111_S5) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z111_S5 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018400/ScoringFiles/PGS018400.txt.gz |
| PGS018401 (GWAS_disc_Z117_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z117_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018401/ScoringFiles/PGS018401.txt.gz |
| PGS018404 (GWAS_disc_Z125_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z125_S4 | magnetic resonance imaging of the heart | 1,105,488 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018404/ScoringFiles/PGS018404.txt.gz |
| PGS018409 (MultiPRS_heart-failure) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Heart failure | heart failure | 1,105,535 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018409/ScoringFiles/PGS018409.txt.gz |
| PGS018410 (MultiPRS_high-cholesterol) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Hypercholesterolaemia (high cholesterol) | Hypercholesterolemia | 1,105,536 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018410/ScoringFiles/PGS018410.txt.gz |
| PGS018412 (MultiPRS_myocardial-infarction) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Myocardial infarction | myocardial infarction | 1,105,535 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018412/ScoringFiles/PGS018412.txt.gz |
| PGS018369 (GWAS_disc_Z28_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z28_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018369/ScoringFiles/PGS018369.txt.gz |
| PGS018382 (GWAS_disc_Z77_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z77_S3 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018382/ScoringFiles/PGS018382.txt.gz |
| PGS018389 (GWAS_disc_Z89_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z89_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018389/ScoringFiles/PGS018389.txt.gz |
| PGS018367 (GWAS_disc_Z26_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z26_S3 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018367/ScoringFiles/PGS018367.txt.gz |
| PGS018368 (GWAS_disc_Z27_S2) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z27_S2 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018368/ScoringFiles/PGS018368.txt.gz |
| PGS018388 (GWAS_disc_Z87_S3) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z87_S3 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018388/ScoringFiles/PGS018388.txt.gz |
| PGS018396 (GWAS_disc_Z105_S4) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z105_S4 | magnetic resonance imaging of the heart | 1,105,485 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018396/ScoringFiles/PGS018396.txt.gz |
| PGS018403 (GWAS_disc_Z122_S1) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Cardiac MRI 3D diffusion-autoencoder latent phenotype Z122_S1 | magnetic resonance imaging of the heart | 1,105,486 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018403/ScoringFiles/PGS018403.txt.gz |
| PGS018411 (MultiPRS_hypertension) |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Hypertension | Hypertension | 1,105,536 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018411/ScoringFiles/PGS018411.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM036543 | PGS018410 (MultiPRS_high-cholesterol) |
PSS012299| European Ancestry| 16,409 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident Hypercholesterolaemia (high cholesterol) (1-10 yr) | HR: 1.07 [1.06, 1.09] OR: 2.2 |
AUROC: 0.636 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.7905); HR per SD of PRS from Cox model (col D); DeLong p=0.1554642066384006. Sex='Both'. |
| PPM036544 | PGS018410 (MultiPRS_high-cholesterol) |
PSS012300| European Ancestry| 66,734 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Hypercholesterolaemia (high cholesterol) | OR: 2.63 | AUROC: 0.6709 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=0.9651); DeLong p=2.460537834968397e-12. Sex='Both'. |
| PPM036545 | PGS018411 (MultiPRS_hypertension) |
PSS012301| European Ancestry| 75,251 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Hypertension | OR: 3.14 | AUROC: 0.694 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1429); DeLong p=1.782553870375481e-14. Sex='Both' (male/female strata also in Suppl. Data 27). |
| PPM036546 | PGS018411 (MultiPRS_hypertension) |
PSS012302| European Ancestry| 26,663 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident Hypertension (1-10 yr) | HR: 1.04 [1.02, 1.05] OR: 2.12 |
AUROC: 0.6336 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.7529); HR per SD of PRS from Cox model (col D); DeLong p=0.4962699408776705. Sex='Both'. |
| PPM036547 | PGS018411 (MultiPRS_hypertension) |
PSS012303| European Ancestry| 111,853 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Hypertension | OR: 2.98 | AUROC: 0.7053 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.0932); DeLong p=2.275480499194408e-13. Sex='Both'. |
| PPM036548 | PGS018412 (MultiPRS_myocardial-infarction) |
PSS012304| European Ancestry| 7,838 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Myocardial infarction | OR: 3.38 | AUROC: 0.7132 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.2168); DeLong p=0.9822239038128628. Sex='Both' (male/female strata also in Suppl. Data 27). |
| PPM036549 | PGS018412 (MultiPRS_myocardial-infarction) |
PSS012305| European Ancestry| 5,984 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident Myocardial infarction (1-10 yr) | HR: 0.95 [0.92, 0.97] OR: 2.46 |
AUROC: 0.6571 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.899); HR per SD of PRS from Cox model (col D); DeLong p=0.9361436146977564. Sex='Both'. |
| PPM036550 | PGS018412 (MultiPRS_myocardial-infarction) |
PSS012306| European Ancestry| 16,433 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Myocardial infarction | OR: 2.77 | AUROC: 0.6778 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.0191); DeLong p=0.9610599661066996. Sex='Both'. |
| PPM036551 | PGS018413 (MultiPRS_type-2-diabetes) |
PSS012307| European Ancestry| 8,220 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Type 2 diabetes mellitus | OR: 6.87 | AUROC: 0.7912 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.9275); DeLong p=0.0090413145552858. Sex='Both' (male/female strata also in Suppl. Data 27). |
| PPM036552 | PGS018413 (MultiPRS_type-2-diabetes) |
PSS012308| European Ancestry| 10,653 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident Type 2 diabetes mellitus (1-10 yr) | HR: 1.09 [1.07, 1.11] OR: 6.2 |
AUROC: 0.7828 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=1.8243); HR per SD of PRS from Cox model (col D); DeLong p=0.0107009135768837. Sex='Both'. |
| PPM036553 | PGS018413 (MultiPRS_type-2-diabetes) |
PSS012309| European Ancestry| 22,631 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Type 2 diabetes mellitus | OR: 6.21 | AUROC: 0.7845 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.8267); DeLong p=7.101564876034609e-05. Sex='Both'. |
| PPM036533 | PGS018407 (MultiPRS_angina-pectoris) |
PSS012289| European Ancestry| 12,866 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Angina pectoris | OR: 3.41 | AUROC: 0.7123 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.2271); DeLong p=0.3170729433287028. Sex='Both' (male/female strata also in Suppl. Data 27). |
| PPM036534 | PGS018407 (MultiPRS_angina-pectoris) |
PSS012290| European Ancestry| 6,879 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident angina pectoris (1-10 yr) | HR: 1.06 [1.04, 1.09] OR: 2.41 |
AUROC: 0.6532 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.8779); HR per SD of PRS from Cox model (col D); DeLong p=0.7222553545891928. Sex='Both'. |
| PPM036535 | PGS018407 (MultiPRS_angina-pectoris) |
PSS012291| European Ancestry| 22,203 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Angina pectoris | OR: 2.98 | AUROC: 0.6837 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.0916); DeLong p=0.0002498157639271. Sex='Both'. |
| PPM036536 | PGS018408 (MultiPRS_coronary-heart-disease) |
PSS012292| European Ancestry| 10,135 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Coronary heart disease | OR: 3.14 | AUROC: 0.6996 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1441); DeLong p=0.4525863322595239. Sex='Both' (male/female strata also in Suppl. Data 27). |
| PPM036537 | PGS018408 (MultiPRS_coronary-heart-disease) |
PSS012293| European Ancestry| 12,832 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident Coronary heart disease (1-10 yr) | HR: 1.07 [1.05, 1.08] OR: 2.5 |
AUROC: 0.6568 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.9148); HR per SD of PRS from Cox model (col D); DeLong p=0.3953316390827512. Sex='Both'. |
| PPM036538 | PGS018408 (MultiPRS_coronary-heart-disease) |
PSS012294| European Ancestry| 27,939 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Coronary heart disease | OR: 2.66 | AUROC: 0.6669 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=0.9788); DeLong p=0.0328749776164314. Sex='Both'. |
| PPM036539 | PGS018409 (MultiPRS_heart-failure) |
PSS012295| European Ancestry| 2,553 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Heart failure | OR: 3.1 | AUROC: 0.6913 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1328); DeLong p=0.183869673873534. Sex='Both' (male/female strata also in Suppl. Data 27). |
| PPM036540 | PGS018409 (MultiPRS_heart-failure) |
PSS012296| European Ancestry| 8,142 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Incident Heart failure (1-10 yr) | HR: 0.96 [0.94, 0.97] OR: 3.16 |
AUROC: 0.6932 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=1.1508); HR per SD of PRS from Cox model (col D); DeLong p=0.6353568793886567. Sex='Both'. |
| PPM036541 | PGS018409 (MultiPRS_heart-failure) |
PSS012297| European Ancestry| 14,172 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Heart failure | OR: 3.01 | AUROC: 0.6836 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.102); DeLong p=0.7920128596259659. Sex='Both'. |
| PPM036542 | PGS018410 (MultiPRS_high-cholesterol) |
PSS012298| European Ancestry| 43,997 individuals |
PGP000826 | Ometto S et al. Nat Commun (2026) |
Reported Trait: Prevalent Hypercholesterolaemia (high cholesterol) | OR: 2.9 | AUROC: 0.682 | — | age, sex, body surface area, PC1-PC20 | Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.0659); DeLong p=7.96893866331471e-07. Sex='Both' (male/female strata also in Suppl. Data 27). |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012289 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 12,866 individuals | — | European | — | UKB | — |
| PSS012290 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 6,879 individuals | — | European | — | UKB | — |
| PSS012291 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 22,203 individuals | — | European | — | UKB | — |
| PSS012292 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 10,135 individuals | — | European | — | UKB | — |
| PSS012293 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 12,832 individuals | — | European | — | UKB | — |
| PSS012294 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 27,939 individuals | — | European | — | UKB | — |
| PSS012295 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 2,553 individuals | — | European | — | UKB | — |
| PSS012296 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 8,142 individuals | — | European | — | UKB | — |
| PSS012297 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 14,172 individuals | — | European | — | UKB | — |
| PSS012298 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 43,997 individuals | — | European | — | UKB | — |
| PSS012299 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 16,409 individuals | — | European | — | UKB | — |
| PSS012300 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 66,734 individuals | — | European | — | UKB | — |
| PSS012301 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 75,251 individuals | — | European | — | UKB | — |
| PSS012302 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 26,663 individuals | — | European | — | UKB | — |
| PSS012303 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 111,853 individuals | — | European | — | UKB | — |
| PSS012304 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 7,838 individuals | — | European | — | UKB | — |
| PSS012305 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 5,984 individuals | — | European | — | UKB | — |
| PSS012306 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 16,433 individuals | — | European | — | UKB | — |
| PSS012307 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 8,220 individuals | — | European | — | UKB | — |
| PSS012308 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 10,653 individuals | — | European | — | UKB | — |
| PSS012309 | Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. | — | 22,631 individuals | — | European | — | UKB | — |