Polygenic Score (PGS) ID: PGS018416

Predicted Trait
Reported Trait Knee osteoarthritis
Mapped Trait(s) osteoarthritis, knee (MONDO_0005416)
Released in PGS Catalog: July 15, 2026
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Score Details

Score Construction
PGS Name PRS_knee
Development Method
Name genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 83
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000833
Citation (link to publication) Wei Y et al. Clin Nutr (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 98.9%
East Asian: 1.1%
396,044 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90034523
Europe PMC: 34450027
 391,749 individuals European 12 cohorts
  • ARGO
  • ,BBJ
  • ,EB
  • ,GARP
  • ,HUNT
  • ,LLS
  • ,MyCode
  • ,NR
  • ,RS
  • ,UKB
  • ,arcOGEN
  • ,deCODE
GWAS Catalog: GCST90034523
Europe PMC: 34450027
 4,295 individuals East Asian 12 cohorts
  • ARGO
  • ,BBJ
  • ,EB
  • ,GARP
  • ,HUNT
  • ,LLS
  • ,MyCode
  • ,NR
  • ,RS
  • ,UKB
  • ,arcOGEN
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036596 PSS012319|
European Ancestry|
163,987 individuals
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Reported Trait: Knee osteoarthritis — — Hazard ratio (HR, high vs low tertile): 1.43 [1.34, 1.53] age, sex, BMI, education levels, Townsend deprivation index, physical activity, ethnic background, smoking status, drinking status, family history of diseases (hypertension, cardiovascular disease, and diabetes), depression, chondroitin product intake, 10 genetic principal components, genotype measurement batch, healthy dietary score and total energy intake —
PPM036598 PSS012319|
European Ancestry|
163,987 individuals
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Reported Trait: Knee osteoarthritis x ultra-processed food (UPF) consumption interaction — — Hazard ratio (HR, high UPF consumption and high PRS vs. low UPF consumption and low PRS): 1.56 [1.37, 1.79] age, sex, BMI, education levels, Townsend deprivation index, physical activity, ethnic background, smoking status, drinking status, family history of diseases (hypertension, cardiovascular disease, and diabetes), depression, chondroitin product intake, 10 genetic principal components, genotype measurement batch, healthy dietary score and total energy intake —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012319 — — 163,987 individuals,
45.1 % Male samples
 Mean = 55.5 years
Sd = 7.9 years		 European — UKB —