PGS Publication: PGP000833

Publication Information (EuropePMC)
Title Ultra-processed food consumption, genetic susceptibility, and the risk of hip/knee osteoarthritis.
PubMed ID 38678821(Europe PMC)
doi 10.1016/j.clnu.2024.04.030
Publication Date April 22, 2024
Journal Clin Nutr
Author(s) Wei Y, Zhang T, Liu Y, Liu H, Zhou Y, Su J, Chen L, Bai L, Xia Y.
Released in PGS Catalog: July 15, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018416
(PRS_knee)
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Knee osteoarthritis osteoarthritis, knee 83
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018416/ScoringFiles/PGS018416.txt.gz
PGS018417
(PRS_hip)
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Hip osteoarthritis osteoarthritis, hip 70
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018417/ScoringFiles/PGS018417.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036595 PGS018417
(PRS_hip)
 PSS012319|
European Ancestry|
163,987 individuals
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Reported Trait: Hip osteoarthritis — — Hazard ratio (HR, high vs low tertile): 1.76 [1.62, 1.9] age, sex, BMI, education levels, Townsend deprivation index, physical activity, ethnic background, smoking status, drinking status, family history of diseases (hypertension, cardiovascular disease, and diabetes), depression, chondroitin product intake, 10 genetic principal components, genotype measurement batch, healthy dietary score and total energy intake —
PPM036596 PGS018416
(PRS_knee)
 PSS012319|
European Ancestry|
163,987 individuals
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Reported Trait: Knee osteoarthritis — — Hazard ratio (HR, high vs low tertile): 1.43 [1.34, 1.53] age, sex, BMI, education levels, Townsend deprivation index, physical activity, ethnic background, smoking status, drinking status, family history of diseases (hypertension, cardiovascular disease, and diabetes), depression, chondroitin product intake, 10 genetic principal components, genotype measurement batch, healthy dietary score and total energy intake —
PPM036597 PGS018417
(PRS_hip)
 PSS012319|
European Ancestry|
163,987 individuals
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Reported Trait: Hip osteoarthritis x ultra-processed food (UPF) consumption interaction — — Hazard ratio (HR, high UPF consumption and high PRS vs. low UPF consumption and low PRS): 1.82 [1.54, 2.15] age, sex, BMI, education levels, Townsend deprivation index, physical activity, ethnic background, smoking status, drinking status, family history of diseases (hypertension, cardiovascular disease, and diabetes), depression, chondroitin product intake, 10 genetic principal components, genotype measurement batch, healthy dietary score and total energy intake —
PPM036598 PGS018416
(PRS_knee)
 PSS012319|
European Ancestry|
163,987 individuals
 PGP000833 |
Wei Y et al. Clin Nutr (2024)
 Reported Trait: Knee osteoarthritis x ultra-processed food (UPF) consumption interaction — — Hazard ratio (HR, high UPF consumption and high PRS vs. low UPF consumption and low PRS): 1.56 [1.37, 1.79] age, sex, BMI, education levels, Townsend deprivation index, physical activity, ethnic background, smoking status, drinking status, family history of diseases (hypertension, cardiovascular disease, and diabetes), depression, chondroitin product intake, 10 genetic principal components, genotype measurement batch, healthy dietary score and total energy intake —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012319 — — 163,987 individuals,
45.1 % Male samples
 Mean = 55.5 years
Sd = 7.9 years		 European — UKB —