Polygenic Score (PGS) ID: PGS018418

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: July 15, 2026
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Score Details

Score Construction
PGS Name T2D_GRS
Development Method
Name Genome-wide significant SNPs
Parameters P < 5 × 10−8
Variants
Original Genome Build NR
Number of Variants 37
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000834
Citation (link to publication) Wu S et al. Maturitas (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
159,208 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004773
Europe PMC: 28566273
 159,208 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036599 PSS012320|
European Ancestry|
146,343 individuals
 PGP000834 |
Wu S et al. Maturitas (2024)
 Reported Trait: Incident type 2 diabetes — — Hazard ratio (HR, high vs low tertile): 1.84 [1.71, 1.99] Age at baseline, assessment center, genotyping batch, first ten genetic principal components —
PPM036600 PSS012320|
European Ancestry|
146,343 individuals
 PGP000834 |
Wu S et al. Maturitas (2024)
 Reported Trait: Incident type 2 diabetes x premature menopause interaction — — Hazard ratio (HR, surgical premature menopause and high PRS vs. without premature menopause and low PRS): 2.61 [1.65, 4.12] age, assessment centre, Townsend Deprivation index, alcohol consumption, smoking status, body mass index, physical activity, healthy diet score, serum total cholesterol, hypertension, cardiovascular disease, family history of diabetes, age at menarche, the use of hormone replacement therapy, the number of live births, genotyping batch, and the first ten genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012320 — — 146,343 individuals,
0.0 % Male samples
 — European — UKB —