PGS Publication: PGP000834

Publication Information (EuropePMC)
Title The role of sex hormone binding globulin levels in the association of surgical and natural premature menopause with incident type 2 diabetes.
PubMed ID 38991416(Europe PMC)
doi 10.1016/j.maturitas.2024.108063
Publication Date July 10, 2024
Journal Maturitas
Author(s) Wu S, Zhong Q, Song Q, Wang M.
Released in PGS Catalog: July 15, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018418
(T2D_GRS)
 PGP000834 |
Wu S et al. Maturitas (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 37
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018418/ScoringFiles/PGS018418.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036599 PGS018418
(T2D_GRS)
 PSS012320|
European Ancestry|
146,343 individuals
 PGP000834 |
Wu S et al. Maturitas (2024)
 Reported Trait: Incident type 2 diabetes — — Hazard ratio (HR, high vs low tertile): 1.84 [1.71, 1.99] Age at baseline, assessment center, genotyping batch, first ten genetic principal components —
PPM036600 PGS018418
(T2D_GRS)
 PSS012320|
European Ancestry|
146,343 individuals
 PGP000834 |
Wu S et al. Maturitas (2024)
 Reported Trait: Incident type 2 diabetes x premature menopause interaction — — Hazard ratio (HR, surgical premature menopause and high PRS vs. without premature menopause and low PRS): 2.61 [1.65, 4.12] age, assessment centre, Townsend Deprivation index, alcohol consumption, smoking status, body mass index, physical activity, healthy diet score, serum total cholesterol, hypertension, cardiovascular disease, family history of diabetes, age at menarche, the use of hormone replacement therapy, the number of live births, genotyping batch, and the first ten genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012320 — — 146,343 individuals,
0.0 % Male samples
 — European — UKB —