Polygenic Score (PGS) ID: PGS019946

Predicted Trait
Reported Trait Cutaneous melanoma
Mapped Trait(s) cutaneous melanoma (MONDO_0005012)
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name cm_prs_noannot_sbrc
Development Method
Name SBayesRC
Parameters SBayesRC without functional annotation
Variants
Original Genome Build hg19
Number of Variants 7,280,842
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000838
Citation (link to publication) Wang H et al. Br J Dermatol (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
107,771 individuals (100%)
Score Development/Training
European: 100%
18,315 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 32341527
[
  • 28,849 cases
  • , 78,922 controls
]
 European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 528 cases
  • , 17,787 controls
]
 European CLSA — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038124 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma — C-index: 0.729 (0.013) — MP16 clinical risk score —
PPM038122 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma OR: 1.685 C-index: 0.643 — — —
PPM038123 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma — C-index: 0.67 (0.014) — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013827 — Median = 10.0 years
[
  • 359 cases
  • , 15,923 controls
]
 — European — QSKIN —