PGS Publication: PGP000838

Publication Information (EuropePMC)
Title Genetics versus clinical risk scores for melanoma prediction.
PubMed ID 41968088(Europe PMC)
doi 10.1093/bjd/ljag126
Publication Date July 1, 2026
Journal Br J Dermatol
Author(s) Wang H, Ghajari H, Jayasinghe GJMSR, Seviiri M, Gordon SD, Neale RE, Pandeya N, Olsen CM, MacGregor S, Whiteman DC, Law MH.
Released in PGS Catalog: July 29, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019946
(cm_prs_noannot_sbrc)
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Cutaneous melanoma cutaneous melanoma 7,280,842
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019946/ScoringFiles/PGS019946.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038124 PGS019946
(cm_prs_noannot_sbrc)
 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma — C-index: 0.729 (0.013) — MP16 clinical risk score —
PPM038122 PGS019946
(cm_prs_noannot_sbrc)
 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma OR: 1.685 C-index: 0.643 — — —
PPM038123 PGS019946
(cm_prs_noannot_sbrc)
 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma — C-index: 0.67 (0.014) — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013827 — Median = 10.0 years
[
  • 359 cases
  • , 15,923 controls
]
 — European — QSKIN —