Trait: myocardial infarction

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000612
Description Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. [NCIT: C27996]
Trait category
Cardiovascular disease
Synonyms 28 synonyms
  • Attack - heart
  • Cardiac infarction
  • Cardiac infarction, NOS
  • Heart attack, NOS
  • INFARCTION (MI), MYOCARDIAL
  • Infarct, Myocardial
  • Infarction of heart
  • Infarction of heart, NOS
  • Infarction, Myocardial
  • Infarctions, Myocardial
  • Infarcts, Myocardial
  • MI
  • MI - Myocardial infarction
  • MI, MYOCARDIAL INFARCTION
  • MI, myocardial infarction
  • MYOCARDIAL INFARCTION, (MI)
  • Myocardial Infarct
  • Myocardial Infarctions
  • Myocardial Infarcts
  • Myocardial infarction (disorder)
  • Myocardial infarction NOS
  • Myocardial infarction, NOS
  • heart attack
  • infarction (MI), myocardial
  • myocardial infarct
  • myocardial infarction
  • myocardial infarction (disease)
  • myocardial infarction, (MI)
Mapped term(s) 13 mapped terms
  • DOID:5844
  • HP:0001658
  • ICD10:I21
  • ICD10:I22
  • MESH:D009203
  • MONDO:0005068
  • MSH:D009203
  • NCIT:C27996
  • NCIt:C27996
  • OMIM:608446
  • SCTID:22298006
  • SNOMEDCT:22298006
  • UMLS:C0027051

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000710 HC326 PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) Myocardial infarction myocardial infarction 183,566 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000710/ScoringFiles/PGS000710.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001602 PGS000710
(HC326)
 PSS000826 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Myocardial infarction — AUROC: 0.59348 — Age, sex, PCs(1-10) —
PPM001606 PGS000710
(HC326)
 PSS000827 PGP000128 Sinnott-Armstrong N et al. (2021) Reported Trait: Myocardial infarction HR: 1.19 [1.17, 1.22] C-index: 0.707 — Age as time scale, sex, batch, PCs(1-10) —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000826 — — 87,413 individuals — European — UKB —
PSS000827 ICD-10 I21|I22 —
[
  • 7,913 cases
  • , 127,387 controls
]
 — European
(Finnish)		 — FinnGen —