Trait: acute myocardial infarction

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008583
Description Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations. [NCIT: P378]
Trait category
Cardiovascular disease
Synonyms 4 synonyms
  • AMI
  • acute myocardial infarction
  • acute myocardial infarction (disease)
  • myocardial infarction (disease), acute
Mapped terms 58 mapped terms
  • DOID:9408
  • ICD10:I21
  • ICD10CM:I21.9
  • ICD9:410
  • ICD9:410.80
  • ICD9:410.81
  • ICD9:410.82
  • ICD9:410.9
  • ICD9:410.90
  • ICD9:410.91
  • ICD9:410.92
  • MONDO:0004781
  • MedDRA:10000891
  • MedDRA:10000892
  • MedDRA:10000893
  • MedDRA:10000894
  • MedDRA:10000895
  • MedDRA:10000896
  • MedDRA:10000897
  • MedDRA:10000898
  • MedDRA:10000899
  • MedDRA:10000900
  • MedDRA:10000901
  • MedDRA:10000902
  • MedDRA:10000903
  • MedDRA:10000904
  • MedDRA:10000905
  • MedDRA:10000906
  • MedDRA:10000907
  • MedDRA:10000908
  • MedDRA:10000909
  • MedDRA:10000910
  • MedDRA:10000911
  • MedDRA:10000912
  • MedDRA:10000913
  • MedDRA:10000914
  • MedDRA:10000915
  • MedDRA:10000916
  • MedDRA:10000917
  • MedDRA:10000918
  • MedDRA:10000919
  • MedDRA:10000920
  • MedDRA:10000921
  • MedDRA:10000922
  • MedDRA:10000923
  • MedDRA:10000924
  • MedDRA:10000925
  • MedDRA:10000926
  • MedDRA:10000927
  • MedDRA:10000928
  • MedDRA:10000929
  • MedDRA:10000930
  • MedDRA:10000931
  • MedDRA:10066641
  • NCIT:C35204
  • NCIt:C35204
  • SCTID:57054005
  • UMLS:C0155626

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004458
(disease.I21.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 I21 (Acute myocardial infarction) acute myocardial infarction 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004458/ScoringFiles/PGS004458.txt.gz
PGS004528
(meta.I21.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 I21 (Acute myocardial infarction) acute myocardial infarction 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004528/ScoringFiles/PGS004528.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020573 PGS004458
(disease.I21.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: I21 (Acute myocardial infarction) OR: 1.28137 — — — —
PPM020643 PGS004528
(meta.I21.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: I21 (Acute myocardial infarction) OR: 1.39148 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011364 — — 56,192 individuals — European — UKB —