| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0003860 | 
| Description | A benign or malignant neoplasm involving the pancreas. [NCIT: C3305] | Trait categories | 
                
                Cancer
               
                
                Digestive system disorder
               | 
| Synonyms | 25 synonyms 
 | 
| Mapped terms | 12 mapped terms 
 | 
| Child trait(s) | 2 child traits | 
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | Ancestry distribution GWAS Dev Eval | Scoring File (FTP Link) | 
|---|---|---|---|---|---|---|
| PGS000083 (CC_Pancreas) | PGP000050 | Graff RE et al. Nat Commun (2021) | Pancreatic cancer | pancreatic carcinoma | 22 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000083/ScoringFiles/PGS000083.txt.gz | 
| PGS000159 (cGRS_Pancreatic) | PGP000075 | Shi Z et al. Cancer Med (2019) | Pancreatic cancer | pancreatic carcinoma | 9 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000159/ScoringFiles/PGS000159.txt.gz | 
| PGS000385 (PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608) | PGP000118 | Fritsche LG et al. Am J Hum Genet (2020) | Pancreatic cancer | pancreatic carcinoma | 17 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000385/ScoringFiles/PGS000385.txt.gz | |
| PGS000386 (PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608) | PGP000118 | Fritsche LG et al. Am J Hum Genet (2020) | Pancreatic cancer | pancreatic carcinoma | 10 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000386/ScoringFiles/PGS000386.txt.gz | |
| PGS000663 (wGRS22) | PGP000123 | Kim J et al. Cancer Epidemiol Biomarkers Prev (2020) | Pancreatic cancer | pancreatic carcinoma | 22 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000663/ScoringFiles/PGS000663.txt.gz | 
| PGS000725 (PRS_Pancreas) | PGP000135 | Jia G et al. JNCI Cancer Spectr (2020) | Pancreatic cancer | pancreatic carcinoma | 22 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000725/ScoringFiles/PGS000725.txt.gz | 
| PGS000794 (CC_Pancreas_IV) | PGP000186 | Kachuri L et al. Nat Commun (2020) | Pancreatic cancer | pancreatic carcinoma | 22 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000794/ScoringFiles/PGS000794.txt.gz | 
| PGS002264 (PRS_Combined) | PGP000293 | Sharma S et al. Gastroenterology (2022) | Pancreatic ductal adenocarcinoma | pancreatic ductal adenocarcinoma | 49 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002264/ScoringFiles/PGS002264.txt.gz | 
| PGS002740 (PRS22_PC) | PGP000347 | Yuan C et al. Ann Oncol (2022) | Pancreatic cancer | pancreatic carcinoma | 22 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002740/ScoringFiles/PGS002740.txt.gz | 
| PGS003742 (PRS19_PC) | PGP000470 | Xin J et al. EBioMedicine (2023) | Pancreatic cancer | pancreatic neoplasm | 19 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003742/ScoringFiles/PGS003742.txt.gz | |
| PGS004250 (PRS19_pancreas) | PGP000542 | Kim ES et al. NPJ Precis Oncol (2023) | Pancreatic cancer | pancreatic carcinoma | 19 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004250/ScoringFiles/PGS004250.txt.gz | 
| PGS004693 (pancreatic_cancer) | PGP000596 | Hu J et al. JNCI Cancer Spectr (2024) | Pancreatic cancer | pancreatic carcinoma | 6,351,686 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004693/ScoringFiles/PGS004693.txt.gz | 
| PGS Performance Metric ID (PPM) | Evaluated Score | PGS Sample Set ID (PSS) | Performance Source | Trait | PGS Effect Sizes (per SD change) | Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information | 
|---|---|---|---|---|---|---|---|---|---|
| PPM000203 | PGS000083 (CC_Pancreas) | PSS000122| European Ancestry| 411,019 individuals | PGP000050 | Graff RE et al. Nat Commun (2021) | Reported Trait: Pancreatic cancer | OR: 1.44 [1.33, 1.55] | — | — | Genotyping reagent kit (GERA cohort only), genotyping array (UK Biobank only), age, sex, 10 PCs. | Results from meta-analysis of GERA and UKB | 
| PPM002049 | PGS000083 (CC_Pancreas) | PSS001022| European Ancestry| 391,491 individuals | PGP000186 | Kachuri L et al. Nat Commun (2020)|Ext. | Reported Trait: Incident pancreatic cancer | HR: 1.49 [1.36, 1.62] | AUROC: 0.745 C-index: 0.742 (0.012) | — | Age at assessment, sex, genotyping array, PCs(1-15), family history of cancer (prostate, breast, lung, bowel), body mass index, cigarette pack-years, smoking status (never vs. former vs. current) | C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years. | 
| PPM017171 | PGS000083 (CC_Pancreas) | PSS010154| European Ancestry| 451 individuals | PGP000443 | Byrne S et al. Int J Epidemiol (2023)|Ext. | Reported Trait: Pancreatic cancer | HR: 1.51 [1.38, 1.66] | — | — | age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates | — | 
| PPM000490 | PGS000159 (cGRS_Pancreatic) | PSS000279| European Ancestry| 13,590 individuals | PGP000075 | Shi Z et al. Cancer Med (2019) | Reported Trait: Pancreatic cancer | — | — | Odds Ratio (OR; high vs. average risk groups): 1.67 [1.1, 2.53] | — | — | 
| PPM000479 | PGS000159 (cGRS_Pancreatic) | PSS000279| European Ancestry| 13,590 individuals | PGP000075 | Shi Z et al. Cancer Med (2019) | Reported Trait: Pancreatic cancer | — | — | Mean realative risk: 1.13 [1.07, 1.18] Wilcoxon test (case vs. control) p-value: 0.00015 | — | — | 
| PPM001070 | PGS000385 (PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608) | PSS000565| European Ancestry| 3,591 individuals | PGP000118 | Fritsche LG et al. Am J Hum Genet (2020) | Reported Trait: Pancreatic cancer | OR: 1.384 [1.235, 1.552] β: 0.325 (0.0583) | AUROC: 0.589 [0.559, 0.622] | Nagelkerke's Pseudo-R²: 0.019 Brier score: 0.082 Odds Ratio (OR, top 1% vs. Rest): 2.58 [1.19, 5.57] | age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_P_5e-08_UKB_20200608 | 
| PPM001071 | PGS000386 (PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608) | PSS000565| European Ancestry| 3,591 individuals | PGP000118 | Fritsche LG et al. Am J Hum Genet (2020) | Reported Trait: Pancreatic cancer | OR: 1.342 [1.199, 1.503] β: 0.294 (0.0577) | AUROC: 0.579 [0.548, 0.611] | Nagelkerke's Pseudo-R²: 0.0157 Brier score: 0.0822 Odds Ratio (OR, top 1% vs. Rest): 1.64 [0.655, 4.12] | age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608 | 
| PPM001367 | PGS000663 (wGRS22) | PSS000598| European Ancestry| 1,591 individuals | PGP000123 | Kim J et al. Cancer Epidemiol Biomarkers Prev (2020) | Reported Trait: Pancreatic cancer | OR: 1.37 [1.23, 1.53] | — | — | — | Cross validation approach-testing sample = 20% | 
| PPM001368 | PGS000663 (wGRS22) | PSS000597| European Ancestry| 956 individuals | PGP000123 | Kim J et al. Cancer Epidemiol Biomarkers Prev (2020) | Reported Trait: Pancreatic cancer (0-10 years of follow-up) | OR: 1.46 [1.27, 1.68] | — | — | — | Cross validation approach-testing sample = 20% | 
| PPM001369 | PGS000663 (wGRS22) | PSS000598| European Ancestry| 1,591 individuals | PGP000123 | Kim J et al. Cancer Epidemiol Biomarkers Prev (2020) | Reported Trait: Pancreatic cancer | OR: 1.37 [1.22, 1.53] | AUROC: 0.65 | — | matching factors, age, cohort (also gender), race/ethnicity, smoking status, fasting status, month/year of blood collection, body mass index, waist-to-hip ratio, diabetic status | Cross validation approach-testing sample = 20% | 
| PPM001370 | PGS000663 (wGRS22) | PSS000597| European Ancestry| 956 individuals | PGP000123 | Kim J et al. Cancer Epidemiol Biomarkers Prev (2020) | Reported Trait: Pancreatic cancer (0-10 years of follow-up) | OR: 1.44 [1.25, 1.67] | AUROC: 0.67 | — | matching factors, age, cohort (also gender), race/ethnicity, smoking status, fasting status, month/year of blood collection, body mass index, waist-to-hip ratio, diabetic status | Cross validation approach-testing sample = 20% | 
| PPM022400 | PGS000663 (wGRS22) | PSS011940| East Asian Ancestry| 100,219 individuals | PGP000711 | Zhu M et al. PLoS Med (2025)|Ext. | Reported Trait: Pancreatic Cancer | HR: 1.28 [1.1, 1.48] β: 0.246 | C-index: 0.586 | — | Age,Sex (if applicable),Region,Top 10 genetic ancestry principal components | The HR and C-index values were derived from Cox proportional hazards regression models. | 
| PPM001655 | PGS000725 (PRS_Pancreas) | PSS000859| European Ancestry| 400,812 individuals | PGP000135 | Jia G et al. JNCI Cancer Spectr (2020) | Reported Trait: Incident Pancreatic cancer | — | AUROC: 0.639 [0.613, 0.664] | — | Genotyping array | — | 
| PPM002065 | PGS000794 (CC_Pancreas_IV) | PSS001022| European Ancestry| 391,491 individuals | PGP000186 | Kachuri L et al. Nat Commun (2020) | Reported Trait: Incident pancreatic cancer | HR: 1.49 [1.37, 1.63] | AUROC: 0.745 C-index: 0.743 (0.012) | R²: 0.439 | Age at assessment, sex, genotyping array, PCs(1-15), family history of cancer (prostate, breast, lung, bowel), body mass index, cigarette pack-years, smoking status (never vs. former vs. current) | C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years. | 
| PPM012888 | PGS002264 (PRS_Combined) | PSS009595| Ancestry Not Reported| 11,462 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma | — | AUROC: 0.605 [0.587, 0.623] | Positive predictive values (PPV highest quintile): 14.4 [13, 15.9] | — | — | 
| PPM012894 | PGS002264 (PRS_Combined) | PSS009600| Ancestry Not Reported| 206 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (with long-standing diabetes mellitus) | — | — | Positive predictive values (PPV highest quintile): 0.239 [0.181, 0.303] | — | — | 
| PPM012892 | PGS002264 (PRS_Combined) | PSS009598| Ancestry Not Reported| 10,259 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (without diabetes mellitus) | — | AUROC: 0.594 [0.573, 0.614] | Positive predictive values (PPV highest quintile): 0.119 [0.105, 0.134] | — | — | 
| PPM012895 | PGS002264 (PRS_Combined) | PSS009600| Ancestry Not Reported| 206 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (with long-standing diabetes mellitus) | OR: 1.873 [1.53, 2.292] | — | — | principal components (PC 1-10) | — | 
| PPM012896 | PGS002264 (PRS_Combined) | PSS009601| Ancestry Not Reported| 998 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (with new onset diabetes mellitus) | — | — | Positive predictive values (PPV highest quintile): 0.867 [0.732, 0.949] | — | — | 
| PPM012897 | PGS002264 (PRS_Combined) | PSS009601| Ancestry Not Reported| 998 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (with new onset diabetes mellitus) | OR: 1.885 [1.279, 2.778] | — | — | principal components (PC 1-10) | — | 
| PPM012898 | PGS002264 (PRS_Combined) | PSS009596| Ancestry Not Reported| 1,203 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (with diabetes mellitus) | OR: 1.674 [1.443, 1.942] | — | — | principal components (PC 1-10) | — | 
| PPM012899 | PGS002264 (PRS_Combined) | PSS009596| Ancestry Not Reported| 1,203 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (with diabetes mellitus) | — | AUROC: 0.645 | — | — | — | 
| PPM012900 | PGS002264 (PRS_Combined) | PSS009597| Ancestry Not Reported| 242 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (< 60 years) | OR: 1.633 [1.292, 2.064] | — | — | principal components (PC 1-10) | — | 
| PPM012901 | PGS002264 (PRS_Combined) | PSS009599| Ancestry Not Reported| 274 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (60 years) | OR: 1.538 [1.287, 1.837] | — | — | principal components (PC 1-10) | — | 
| PPM012893 | PGS002264 (PRS_Combined) | PSS009598| Ancestry Not Reported| 10,259 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma (without diabetes mellitus) | OR: 1.386 [1.288, 1.492] | — | — | principal components (PC 1-10) | — | 
| PPM012889 | PGS002264 (PRS_Combined) | PSS009595| Ancestry Not Reported| 11,462 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma | — | — | HR (highest vs lowest quintile): 2.738 [2.227, 3.365] | Smoking (never, current and previous), waist circumference (cm), DM onset (No DM, NODM, LSDM) and first-degree family history of digestive cancer (yes/no) | — | 
| PPM012890 | PGS002264 (PRS_Combined) | PSS009595| Ancestry Not Reported| 11,462 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma | — | AUROC: 0.83 [0.8, 0.86] | — | Age of participants at recruitment, age when DM diagnosed, DM onset (No DM, NODM, LSDM), waist circumference (cm), and first-degree family history of digestive cancer (yes/no)., clinical risk | — | 
| PPM012891 | PGS002264 (PRS_Combined) | PSS009595| Ancestry Not Reported| 11,462 individuals | PGP000293 | Sharma S et al. Gastroenterology (2022) | Reported Trait: Incident pancreatic ductal adenocarcinoma | OR: 1.43 | — | — | principal components (PC 1-10) | — | 
| PPM014844 | PGS002740 (PRS22_PC) | PSS009913| European Ancestry| 13,952 individuals | PGP000347 | Yuan C et al. Ann Oncol (2022) | Reported Trait: Pancreatic cancer in those aged <= 60 years | — | — | Odds ratio (OR, top vs bottom 10%): 6.91 [4.6, 10.4] | — | — | 
| PPM014843 | PGS002740 (PRS22_PC) | PSS009913| European Ancestry| 13,952 individuals | PGP000347 | Yuan C et al. Ann Oncol (2022) | Reported Trait: Pancreatic cancer in those aged >70 years | — | — | Odds ratio (OR, top vs bottom 10%): 4.12 [3.08, 5.52] | — | — | 
| PPM018498 | PGS003742 (PRS19_PC) | PSS010993| European Ancestry| 153 individuals | PGP000470 | Xin J et al. EBioMedicine (2023) | Reported Trait: Pancreatic cancer | OR: 1.33 [1.13, 1.57] | — | — | — | — | 
| PPM020307 | PGS004250 (PRS19_pancreas) | PSS011328| European Ancestry| 133,830 individuals | PGP000542 | Kim ES et al. NPJ Precis Oncol (2023) | Reported Trait: Pancreatic cancer | HR: 1.37 [1.16, 1.61] | — | — | first 10 genetic principal components | — | 
| PPM020314 | PGS004250 (PRS19_pancreas) | PSS011329| European Ancestry| 115,207 individuals | PGP000542 | Kim ES et al. NPJ Precis Oncol (2023) | Reported Trait: Pancreatic cancer | HR: 1.39 [1.2, 1.61] | — | — | first 10 genetic principal components | — | 
| PPM020878 | PGS004693 (pancreatic_cancer) | PSS011437| European Ancestry| 40,877 individuals | PGP000596 | Hu J et al. JNCI Cancer Spectr (2024) | Reported Trait: Pancreatic cancer | — | AUROC: 0.5426 | — | — | — | 
| PGS Sample Set ID (PSS) | Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information | 
|---|---|---|---|---|---|---|---|---|
| PSS000122 | Cancer diagnoses were obtained from reigstry data in GERA, and ICD-9/10 codes mapped to ICD-O-3 codes in UK Biobank. Cancers for this phenotype were classified using the following SEER site recode(s): 21100 | — | [, 
 46.0 % Male samples | Mean = 58.0 years | European | — | GERA, UKB | — | 
| PSS009913 | — | — | [ 
 | — | European | — | PANSCAN | — | 
| PSS000565 | PheCode:157; ICD9:157, 157.0, 157.1, 157.2, 157.3, 157.4, 157.8, 157.9; ICD10:C25.0, C25.1, C25.2, C25.3, C25.4, C25.7, C25.8, C25.9 | — | [ 
 | — | European | — | UKB | — | 
| PSS011328 | — | — | 133,830 individuals, 0.0 % Male samples | — | European (British) | — | UKB | — | 
| PSS011329 | — | — | 115,207 individuals, 100.0 % Male samples | — | European (British) | — | UKB | — | 
| PSS010993 | — | — | 153 individuals | Mean = 65.63 years | European | — | TCGA | — | 
| PSS011437 | — | — | [ 
 | — | European | — | UKB | — | 
| PSS011940 | ICD-10: C25 | Median = 11.33 years Range = [10.18, 12.26] years | [, 
 42.8 % Male samples | Mean = 53.69 years Sd = 11.01 years | East Asian (Chinese) | — | CKB | — | 
| PSS009595 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. | Median = 109.0 months | [, 
 52.0 % Male samples | Mean = 61.3 years | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | 
| PSS009596 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. | — | [ 
 | — | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | 
| PSS009597 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. | — | [ 
 | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | |
| PSS009598 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. | — | [ 
 | — | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | 
| PSS009599 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. | — | [ 
 | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | |
| PSS009600 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. LSDM is defined in cases as type 2 diabetes diagnosed more than 24 months before PDAC diagnosis. Defined in controls as type 2 diabetes diagnosed more than 24 months before date of death or date of last follow up. | — | [ 
 | — | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | 
| PSS009601 | PDAC cases were considered incident if diagnosed after study entry or without a date of diagnosis if identified by mortality alone. NODM is defined in cases as type 2 diabetes diagnosed within 24 months before or after diagnosis of PDAC. Defined in controls as type 2 diabetes diagnosed 24 months before death or last follow up. | — | [ 
 | — | Not reported | European, African American or Afro-Caribbean, South Asian, East Asian, African unspecified | UKB | — | 
| PSS000597 | In this study, cases were incident patients with primary pancreatic adenocarcinoma ascertained between 1984 and 2010 through self- report, report of next-of-kin, or death certificates and confirmed by medical record review and tumor registry data. Cases Diagnosed within 10 years of blood collection. | Mean = 10.0 years | [, 
 28.1 % Male samples | — | European | — | HPFS, NHS, PHS, WHI | Overlap with GWAS samples (percentage unknown). Cross validation approach used (20% as testing sample) | 
| PSS000598 | In this study, cases were incident patients with primary pancreatic adenocarcinoma ascertained between 1984 and 2010 through self- report, report of next-of-kin, or death certificates and confirmed by medical record review and tumor registry data. | — | [, 
 33.4 % Male samples | — | European | — | HPFS, NHS, PHS, WHI | Overlap with GWAS samples (percentage unknown). Cross validation approach used (20% as testing sample) | 
| PSS000859 | Data and diagnoses on site-specific incident cancers were provided by the National Health Service Information Centre for participants from England and Wales (follow-up through March 31, 2016) and by the NHS Central Register Scotland for participants from Scotland (follow-up through October 31, 2015). Cancers were coded by the International Classification of Diseases, Ninth Revision (ICD-9) or the International Classification of Diseases, Tenth Revision (ICD-10). Pancreatic Cancer=(ICD-9 = 157 or ICD-10 = C25) | Median = 5.8 years | [, 
 46.5 % Male samples | — | European | — | UKB | — | 
| PSS010154 | — | — | [ 
 | — | European | — | UKB | — | 
| PSS000279 | Primary tumor samples from TCGA | — | [ 
 | Mean = 66.0 years Sd = 11.0 years | European | — | TCGA | — | 
| PSS000279 | — | — | [ 
 | — | European | — | eMERGE | — | 
| PSS001022 | Individuals with at least one recorded incident diagnosis of a borderline, in situ, or malignant primary cancer were defined as cases. | — | [ 
 | — | European | — | UKB | — |