Trait: Cannabis use

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007585
Description The consumption of the recreational drug cannabis (also known as marijuna and a number of other colloquial names). Cannabis use is illegal in some countries but not in others.
Trait category
Biological process
Synonyms 2 synonyms
  • Cannabis consumption
  • Cannabis use behaviour
Mapped term MedDRA:10070996

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001391
(GBE_INI20453)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Ever taken cannabis Cannabis use 819
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001391/ScoringFiles/PGS001391.txt.gz
PGS001910
(portability-PLR_ever_cannabis)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Ever taken cannabis Cannabis use 9,341
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001910/ScoringFiles/PGS001910.txt.gz
PGS002125
(portability-ldpred2_ever_cannabis)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Ever taken cannabis Cannabis use 816,604
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002125/ScoringFiles/PGS002125.txt.gz
PGS003504
(cont-decay-ever_cannabis)
 PGP000457 |
Ding Y et al. Nature (2023)
 Ever taken cannabis Cannabis use 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003504/ScoringFiles/PGS003504.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005255 PGS001391
(GBE_INI20453)
 PSS004906|
African Ancestry|
915 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ever taken cannabis — — R²: 0.08388 [0.07099, 0.09678]
Incremental R2 (full-covars): -0.0006
PGS R2 (no covariates): 0.00037 [-0.00056, 0.0013]		 age, sex, UKB array type, Genotype PCs —
PPM005256 PGS001391
(GBE_INI20453)
 PSS004907|
East Asian Ancestry|
362 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ever taken cannabis — — R²: 0.02498 [0.01038, 0.03959]
Incremental R2 (full-covars): -0.00599
PGS R2 (no covariates): 0.00101 [-0.002, 0.00401]		 age, sex, UKB array type, Genotype PCs —
PPM005257 PGS001391
(GBE_INI20453)
 PSS004908|
European Ancestry|
8,139 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ever taken cannabis — — R²: 0.08763 [0.08092, 0.09434]
Incremental R2 (full-covars): 0.00226
PGS R2 (no covariates): 0.00384 [0.00231, 0.00537]		 age, sex, UKB array type, Genotype PCs —
PPM005258 PGS001391
(GBE_INI20453)
 PSS004909|
South Asian Ancestry|
1,047 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ever taken cannabis — — R²: 0.04702 [0.03787, 0.05616]
Incremental R2 (full-covars): -0.00092
PGS R2 (no covariates): 0.00033 [-0.00048, 0.00114]		 age, sex, UKB array type, Genotype PCs —
PPM005259 PGS001391
(GBE_INI20453)
 PSS004910|
European Ancestry|
22,015 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ever taken cannabis — — R²: 0.06878 [0.06509, 0.07247]
Incremental R2 (full-covars): 0.00123
PGS R2 (no covariates): 0.00117 [0.00065, 0.00169]		 age, sex, UKB array type, Genotype PCs —
PPM010163 PGS001910
(portability-PLR_ever_cannabis)
 PSS009402|
European Ancestry|
5,865 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.071 [0.0455, 0.0965] sex, age, birth date, deprivation index, 16 PCs —
PPM010164 PGS001910
(portability-PLR_ever_cannabis)
 PSS009176|
European Ancestry|
1,104 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0914 [0.0321, 0.1502] sex, age, birth date, deprivation index, 16 PCs —
PPM010165 PGS001910
(portability-PLR_ever_cannabis)
 PSS008730|
European Ancestry|
2,006 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0329 [-0.0111, 0.0768] sex, age, birth date, deprivation index, 16 PCs —
PPM010166 PGS001910
(portability-PLR_ever_cannabis)
 PSS008504|
Greater Middle Eastern Ancestry|
186 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0068 [-0.1456, 0.159] sex, age, birth date, deprivation index, 16 PCs —
PPM010167 PGS001910
(portability-PLR_ever_cannabis)
 PSS008282|
South Asian Ancestry|
784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): -0.0078 [-0.0787, 0.0631] sex, age, birth date, deprivation index, 16 PCs —
PPM010169 PGS001910
(portability-PLR_ever_cannabis)
 PSS007846|
African Ancestry|
333 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0465 [-0.0647, 0.1565] sex, age, birth date, deprivation index, 16 PCs —
PPM010170 PGS001910
(portability-PLR_ever_cannabis)
 PSS008950|
African Ancestry|
482 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): -0.0235 [-0.1145, 0.0679] sex, age, birth date, deprivation index, 16 PCs —
PPM010168 PGS001910
(portability-PLR_ever_cannabis)
 PSS008059|
East Asian Ancestry|
405 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): -0.0454 [-0.1447, 0.0548] sex, age, birth date, deprivation index, 16 PCs —
PPM011855 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS009402|
European Ancestry|
5,865 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0878 [0.0623, 0.1131] sex, age, birth date, deprivation index, 16 PCs —
PPM011856 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS009176|
European Ancestry|
1,104 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0861 [0.0267, 0.1449] sex, age, birth date, deprivation index, 16 PCs —
PPM011857 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS008730|
European Ancestry|
2,006 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0935 [0.0497, 0.1369] sex, age, birth date, deprivation index, 16 PCs —
PPM011858 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS008504|
Greater Middle Eastern Ancestry|
186 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0343 [-0.1186, 0.1857] sex, age, birth date, deprivation index, 16 PCs —
PPM011859 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS008282|
South Asian Ancestry|
784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0754 [0.0045, 0.1455] sex, age, birth date, deprivation index, 16 PCs —
PPM011860 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS008059|
East Asian Ancestry|
405 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): -0.0487 [-0.1479, 0.0515] sex, age, birth date, deprivation index, 16 PCs —
PPM011861 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS007846|
African Ancestry|
333 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0181 [-0.0929, 0.1287] sex, age, birth date, deprivation index, 16 PCs —
PPM011862 PGS002125
(portability-ldpred2_ever_cannabis)
 PSS008950|
African Ancestry|
482 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever taken cannabis — — Partial Correlation (partial-r): 0.0517 [-0.0398, 0.1422] sex, age, birth date, deprivation index, 16 PCs —
PPM017600 PGS003504
(cont-decay-ever_cannabis)
 PSS010613|
European Ancestry|
1,938 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017432 PGS003504
(cont-decay-ever_cannabis)
 PSS010865|
European Ancestry|
5,883 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017516 PGS003504
(cont-decay-ever_cannabis)
 PSS010781|
European Ancestry|
1,104 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017684 PGS003504
(cont-decay-ever_cannabis)
 PSS010529|
Greater Middle Eastern Ancestry|
186 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017768 PGS003504
(cont-decay-ever_cannabis)
 PSS010193|
European Ancestry|
837 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017852 PGS003504
(cont-decay-ever_cannabis)
 PSS010445|
South Asian Ancestry|
784 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017936 PGS003504
(cont-decay-ever_cannabis)
 PSS010361|
East Asian Ancestry|
406 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018020 PGS003504
(cont-decay-ever_cannabis)
 PSS010277|
African Ancestry|
333 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018104 PGS003504
(cont-decay-ever_cannabis)
 PSS010697|
African Ancestry|
481 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Ever taken cannabis — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010529 — — 186 individuals,
57.0 % Male samples
 Mean = 54.0 years
Sd = 7.2 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010277 — — 333 individuals,
32.0 % Male samples
 Mean = 50.5 years
Sd = 7.5 years		 African American or Afro-Caribbean Caribbean UKB —
PSS009176 — — 1,104 individuals — European Poland (NE Europe) UKB —
PSS008282 — — 784 individuals — South Asian India (South Asia) UKB —
PSS010697 — — 481 individuals,
46.0 % Male samples
 Mean = 50.8 years
Sd = 7.2 years		 African unspecified Nigerian UKB —
PSS010445 — — 784 individuals,
57.0 % Male samples
 Mean = 52.7 years
Sd = 8.2 years		 South Asian Indian UKB —
PSS008950 — — 482 individuals — African unspecified Nigeria (West Africa) UKB —
PSS010193 — — 837 individuals,
43.0 % Male samples
 Mean = 57.7 years
Sd = 7.0 years		 European Ashkenazi UKB —
PSS008059 — — 405 individuals — East Asian China (East Asia) UKB —
PSS010865 — — 5,883 individuals,
45.0 % Male samples
 Mean = 56.5 years
Sd = 7.6 years		 European white British UKB —
PSS008730 — — 2,006 individuals — European Italy (South Europe) UKB —
PSS010613 — — 1,938 individuals,
41.0 % Male samples
 Mean = 54.1 years
Sd = 8.1 years		 European Italian UKB —
PSS010361 — — 406 individuals,
25.0 % Male samples
 Mean = 52.3 years
Sd = 7.3 years		 East Asian Chinese UKB —
PSS007846 — — 333 individuals — African American or Afro-Caribbean Carribean UKB —
PSS004906 — — 915 individuals — African unspecified — UKB —
PSS004907 — — 362 individuals — East Asian — UKB —
PSS004908 — — 8,139 individuals — European non-white British ancestry UKB —
PSS004909 — — 1,047 individuals — South Asian — UKB —
PSS004910 — — 22,015 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS008504 — — 186 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009402 — — 5,865 individuals — European UK (+ Ireland) UKB —
PSS010781 — — 1,104 individuals,
33.0 % Male samples
 Mean = 54.1 years
Sd = 7.3 years		 European Polish UKB —