Trait: chronotype measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008328
Description quantification of some aspect of chronotype such as ease of getting up in the morning
Trait category
Other measurement

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000336 GRS313_Chron PGP000103 Maukonen M et al. J Biol Rhythms (2020) Chronotype chronotype measurement 313 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000336/ScoringFiles/PGS000336.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000906 PGS000336 (GRS313_Chron) PSS000451 PGP000103
Maukonen M et al. (2020)
Reported Trait: Later (evening) chronotype OR: 1.3[1.24, 1.37] : 0.01893 Age, sex, PCs (1-5), genotyping batch
PPM000904 PGS000336 (GRS313_Chron) PSS000453 PGP000103
Maukonen M et al. (2020)
Reported Trait: Later (evening) chronotype β: -0.49 : 0.01378 Age, sex, PCs (1-5), genotyping batch
PPM000905 PGS000336 (GRS313_Chron) PSS000452 PGP000103
Maukonen M et al. (2020)
Reported Trait: Later (evening) chronotype OR: 1.24[1.18, 1.31] : 0.01312 Age, sex, PCs (1-5), genotyping batch

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000451 Chronotype was assessed using a singl self-evaluatation question from a shortend version of Horne and Ostber'gs MEQ (sMEQ) on chronotype. The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. For the single self-evaluation question item 19 was used. The question was used as a binary varable in which those who replied either "rather more an evening than a morning type" or "definitely an evening type" were regarded as evening types, and those who replied "definitely a morning type" or "rather more a morning type than an evening type" were regarrded as morning types.
[
  • 4,674 cases
  • , 3,759 controls
]
,
47.78 % Male samples
European
(Finnish)
FINRISK Included participants from the National FINRISK 2007 and 2012 studies
PSS000452 Chronotype was assessed using a shortend version of Horne and Ostberg's MEQ(sMEQ) . The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. The sum score was used as a binary variable (evening type: socres from 5-15, morning type: socres from 16 to 27; binary sMEQ score).
[
  • 2,364 cases
  • , 5,072 controls
]
,
46.4 % Male samples
European
(Finnish)
FINRISK Included participants from the National FINRISK 2007 and 2012 studies
PSS000453 Chronotype was assessed using a shortend version of Horne and Ostberg's MEQ(sMEQ) The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. The sum score was used as a continuous variable (continuous sMEQ score). 7,436 individuals European
(Finnish)
FINRISK Included participants from the National FINRISK 2007 and 2012 studies