Trait: bipolar I disorder

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009963
Description A bipolar disorder that is characterized by at least one manic or mixed episode.
Trait category
Neurological disorder
Mapped terms 4 mapped terms
  • DOID:14042
  • MedDRA:10004939
  • MedDRA:10068455
  • PMID:31043756

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002787
(BD1_SDPR)
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Type 1 bipolar disorder bipolar I disorder 937,511
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002787/ScoringFiles/PGS002787.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015116 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 3.60e-06 age, PCs1-3 —
PPM015117 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 9e-05 age, PCs1-3 —
PPM015118 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 8e-05 age, PCs1-3 —
PPM015119 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00025 age, PCs1-3 —
PPM015120 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 5e-05 age, PCs1-3 —
PPM015121 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 3e-05 age, PCs1-3 —
PPM015122 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00015 age, PCs1-3 —
PPM015123 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 1e-05 age, PCs1-3 —
PPM015124 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 7.64e-07 age, PCs1-3 —
PPM015125 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 4e-05 age, PCs1-3 —
PPM015126 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 1.57e-09 age, PCs1-3 —
PPM015127 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00019 age, PCs1-3 —
PPM015128 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 3.52e-06 age, PCs1-3 —
PPM015129 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00014 age, PCs1-3 —
PPM015130 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 2.44e-06 age, PCs1-3 —
PPM015132 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 3.41e-06 age, PCs1-3 —
PPM015133 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 3e-05 age, PCs1-3 —
PPM015134 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00031 age, PCs1-3 —
PPM015135 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 2e-05 age, PCs1-3 —
PPM015136 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 3e-05 age, PCs1-3 —
PPM015137 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 9e-05 age, PCs1-3 —
PPM015138 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00046 age, PCs1-3 —
PPM015139 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00067 age, PCs1-3 —
PPM015140 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00164 age, PCs1-3 —
PPM015141 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00045 age, PCs1-3 —
PPM015142 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 2e-05 age, PCs1-3 —
PPM015144 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 5e-05 age, PCs1-3 —
PPM015145 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00115 age, PCs1-3 —
PPM015146 PGS002787
(BD1_SDPR)
 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00013 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015147 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00068 age, PCs1-3 —
PPM015148 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 7.61e-07 age, PCs1-3 —
PPM015149 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00059 age, PCs1-3 —
PPM015150 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00013 age, PCs1-3 —
PPM015151 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00051 age, PCs1-3 —
PPM015152 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 2e-05 age, PCs1-3 —
PPM015153 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00053 age, PCs1-3 —
PPM015155 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00055 age, PCs1-3 —
PPM015156 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00037 age, PCs1-3 —
PPM015157 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00066 age, PCs1-3 —
PPM015158 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00275 age, PCs1-3 —
PPM015159 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00081 age, PCs1-3 —
PPM015160 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00012 age, PCs1-3 —
PPM015161 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 1.13e-06 age, PCs1-3 —
PPM015162 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00032 age, PCs1-3 —
PPM015163 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00024 age, PCs1-3 —
PPM015164 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00022 age, PCs1-3 —
PPM015166 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00057 age, PCs1-3 —
PPM015167 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00079 age, PCs1-3 —
PPM015168 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00021 age, PCs1-3 —
PPM015169 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00022 age, PCs1-3 —
PPM015170 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 4e-05 age, PCs1-3 —
PPM015171 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00016 age, PCs1-3 —
PPM015172 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 7e-05 age, PCs1-3 —
PPM015173 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.00036 age, PCs1-3 —
PPM015174 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 5.31e-06 age, PCs1-3 —
PPM015175 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 0.00072 age, PCs1-3 —
PPM015176 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00027 age, PCs1-3 —
PPM015131 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 2.94e-06 age, PCs1-3 —
PPM015143 PGS002787
(BD1_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00151 age, PCs1-3 —
PPM015154 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00026 age, PCs1-3 —
PPM015165 PGS002787
(BD1_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.0001 age, PCs1-3 —
PPM015177 PGS002787
(BD1_SDPR)
 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00012 age, PCs1-10 the observed partial R² were higher than random R²s

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —