Trait: spontaneous coronary artery dissection

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010820
Description The spontaneous occurrence of a dissection of the coronary artery. The clinical recognition of this phenomenon has increased as coronary angiography is becoming more commonly used in the treatment of acute coronary syndrome. The etiology of the condition has not been fully elucidated, but the mean age of presentation is 30-45 years, more than 70% are women, and 30% of cases occur in the peripartum period.
Trait category
Cardiovascular disease
Synonym SCAD
Mapped terms 2 mapped terms
  • NCIt:C165532
  • PMID:32887874

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004899
(PRS_SCAD)
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Spontaneous coronary artery dissection spontaneous coronary artery dissection 7
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004899/ScoringFiles/PGS004899.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021316 PGS004899
(PRS_SCAD)
 PSS011682|
Ancestry Not Reported|
412 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Spontaneous coronary artery dissection OR: 1.82 [1.09, 3.02]
β: 0.597 (0.259)		 — — Age, sex —
PPM021317 PGS004899
(PRS_SCAD)
 PSS011685|
European Ancestry|
373,056 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction HR: 0.91 [0.89, 0.93]
β: -0.094 (0.011)		 — — Age, sex, genotyping array and batch, PCs (1-4) —
PPM021318 PGS004899
(PRS_SCAD)
 PSS011685|
European Ancestry|
373,056 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction in males HR: 0.91 [0.89, 0.93]
β: -0.092 (0.013)		 — — Age, genotyping array and batch, PCs (1-4) —
PPM021319 PGS004899
(PRS_SCAD)
 PSS011685|
European Ancestry|
373,056 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocaridal infarction in females HR: 0.91 [0.87, 0.95]
β: -0.099 (0.022)		 — — Age, genotyping array and batch, PCs (1-4) —
PPM021320 PGS004899
(PRS_SCAD)
 PSS011683|
European Ancestry|
294,465 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Coronary artery disease OR: 0.95 [0.94, 0.96]
β: -0.05 (0.004)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), sex, PCs(1-10) —
PPM021321 PGS004899
(PRS_SCAD)
 PSS011683|
European Ancestry|
294,465 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Coronary artery disease in males OR: 0.95 [0.94, 0.96]
β: -0.05 (0.004)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), PCs(1-10) —
PPM021322 PGS004899
(PRS_SCAD)
 PSS011684|
European Ancestry|
314,434 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction OR: 0.96 [0.95, 0.98]
β: -0.04 (0.009)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), sex, PCs(1-10) —
PPM021323 PGS004899
(PRS_SCAD)
 PSS011684|
European Ancestry|
314,434 individuals
 PGP000629 |
Saw J et al. Nat Commun (2020)
 Reported Trait: Myocardial infarction in males OR: 0.96 [0.95, 0.98]
β: -0.039 (0.009)		 — — Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), PCs(1-10) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011685 MI events were defined pre- enrollment by self-reported medical history and post-enrollment by hospital epi- sode statistics using ICD, Version 10 diagnosis codes (I21, I22, I23, or I24). Events were censored on the date of loss to follow-up, death, or if individuals remained event free up to March 31, 2017. —
[
  • 15,476 cases
  • , 357,580 controls
]
,
45.86 % Male samples
 — European — UKB —
PSS011682 All individuals had multifocal FMD. Cases show those with spontaneous coronary artery dissection. —
[
  • 28 cases
  • , 384 controls
]
 — Not reported — CCGB Cases from Cleveland Clinic FMD Biorepository
PSS011683 An individual was classified as a case if he or she had ≥1 admission to a VA hospital with discharge diagnosis of acute myocardial infarction (AMI) or ≥1 procedure code for revascularization of the coronary arteries or ≥2 ICD codes for CAD (410-414) on ≥2 dates. —
[
  • 95,347 cases
  • , 199,118 controls
]
 — European — MVP —
PSS011684 Cases are individuals with evidence of hospitilisation for myocardial infarction. —
[
  • 14,802 cases
  • , 299,632 controls
]
 — European — MVP —