Trait: schizophrenia

Trait Information
Identifier MONDO_0005090
Description A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality. [NCIT: P378]
Trait category
Neurological disorder
Synonyms 8 synonyms
  • SCZD
  • schizoaffective disorder
  • schizophrenia
  • schizophrenia (disease)
  • schizophrenia 12
  • schizophrenia with or without an affective disorder
  • schizophrenia, susceptibility to
  • schizophrenia-1
Mapped terms 14 mapped terms
  • DOID:5419
  • EFO:0000692
  • HP:0100753
  • ICD9:295
  • ICD9:295.8
  • ICD9:295.80
  • ICD9:295.85
  • ICD9:295.9
  • ICD9:295.90
  • NCIT:C3362
  • NIFSTD:birnlex_2104
  • OMIM:181500
  • Orphanet:3140
  • SCTID:58214004

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000133
(SCZ_BVU)
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Schizophrenia schizophrenia 604,645
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000133/ScoringFiles/PGS000133.txt.gz
PGS000134
(SCZ_GHS)
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Schizophrenia schizophrenia 830,589
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000134/ScoringFiles/PGS000134.txt.gz
PGS000135
(SCZ_MTS)
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Schizophrenia schizophrenia 972,439
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000135/ScoringFiles/PGS000135.txt.gz
PGS000136
(SCZ_PBK)
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Schizophrenia schizophrenia 833,502
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000136/ScoringFiles/PGS000136.txt.gz
PGS002785
(SCZ_SDPR)
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Schizophrenia schizophrenia 964,422
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002785/ScoringFiles/PGS002785.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000417 PGS000133
(SCZ_BVU)
 PSS000238|
European Ancestry|
33,694 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Psychosis OR: 1.3755 — — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM000413 PGS000133
(SCZ_BVU)
 PSS000237|
European Ancestry|
33,694 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Schizophrenia OR: 1.691 AUROC: 0.6 [0.55, 0.66] — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM000418 PGS000134
(SCZ_GHS)
 PSS000240|
European Ancestry|
44,436 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Psychosis OR: 1.2224 — — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM000414 PGS000134
(SCZ_GHS)
 PSS000239|
European Ancestry|
44,436 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Schizophrenia OR: 1.483 AUROC: 0.6 [0.56, 0.64] — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM000415 PGS000135
(SCZ_MTS)
 PSS000241|
European Ancestry|
9,569 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Schizophrenia — AUROC: 0.74 [0.67, 0.81] — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM000420 PGS000136
(SCZ_PBK)
 PSS000244|
European Ancestry|
18,461 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Psychosis OR: 1.4768 — — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM000416 PGS000136
(SCZ_PBK)
 PSS000243|
European Ancestry|
18,461 individuals
 PGP000065 |
Zheutlin AB et al. Am J Psychiatry (2019)
 Reported Trait: Schizophrenia OR: 1.7 AUROC: 0.64 [0.6, 0.69] — age, sex, 10 PCs of ancestry, genotyping platform, genotyping batch *SNP weights were adjusted for use in this cohort
PPM015033 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00016 age, PCs1-3 —
PPM015034 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00116 age, PCs1-3 —
PPM014992 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00015 age, PCs1-3 —
PPM015043 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00024 age, PCs1-3 —
PPM015364 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Corticospinal tract R — — partial R²: 0.00123 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015035 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00024 age, PCs1-3 —
PPM015036 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00025 age, PCs1-3 —
PPM015037 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.00011 age, PCs1-3 —
PPM015038 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00012 age, PCs1-3 —
PPM015039 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 6.77e-06 age, PCs1-3 —
PPM015040 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.0019 age, PCs1-3 —
PPM014993 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00085 age, PCs1-3 —
PPM014994 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 4.36e-07 age, PCs1-3 —
PPM014995 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00032 age, PCs1-3 —
PPM014996 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00093 age, PCs1-3 —
PPM014997 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00041 age, PCs1-3 —
PPM014998 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00028 age, PCs1-3 —
PPM014999 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00048 age, PCs1-3 —
PPM015000 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00026 age, PCs1-3 —
PPM015001 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00046 age, PCs1-3 —
PPM015002 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00056 age, PCs1-3 —
PPM015003 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00089 age, PCs1-3 —
PPM015005 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00021 age, PCs1-3 —
PPM015006 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.00081 age, PCs1-3 —
PPM015007 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00021 age, PCs1-3 —
PPM015008 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00039 age, PCs1-3 —
PPM015009 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00038 age, PCs1-3 —
PPM015010 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 8e-05 age, PCs1-3 —
PPM015011 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00088 age, PCs1-3 —
PPM015013 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00179 age, PCs1-3 —
PPM015014 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00287 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015015 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.0039 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015016 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00279 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015017 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00062 age, PCs1-3 —
PPM015018 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.0027 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015019 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00502 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015020 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 0.00661 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015021 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00806 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015022 PGS002785
(SCZ_SDPR)
 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00398 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015023 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 8e-05 age, PCs1-3 —
PPM015024 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 4.06e-06 age, PCs1-3 —
PPM015025 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00087 age, PCs1-3 —
PPM015026 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 7e-05 age, PCs1-3 —
PPM015027 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00053 age, PCs1-3 —
PPM015044 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00017 age, PCs1-3 —
PPM015045 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00411 age, PCs1-3 —
PPM015046 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00034 age, PCs1-3 —
PPM015047 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00019 age, PCs1-3 —
PPM015048 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00024 age, PCs1-3 —
PPM015049 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.0001 age, PCs1-3 —
PPM015050 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00146 age, PCs1-3 —
PPM015051 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 4e-05 age, PCs1-3 —
PPM015052 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00082 age, PCs1-3 —
PPM015365 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_61 — — partial R²: 0.00131 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015366 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_103 — — partial R²: 0.00146 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015367 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_109 — — partial R²: 0.00191 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015368 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_130 — — partial R²: 0.00179 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015369 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_132 — — partial R²: 0.00116 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015370 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_149 — — partial R²: 0.00186 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015371 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_184 — — partial R²: 0.00137 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015372 PGS002785
(SCZ_SDPR)
 PSS009954|
European Ancestry|
11,180 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_185 — — partial R²: 0.00234 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015373 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cingulate gyrus anterior division right — — partial R²: 0.00074 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015374 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Middle cerebellar peduncle — — partial R²: 0.00076 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015375 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior cerebellar peduncle R — — partial R²: 0.00097 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015376 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior cerebellar peduncle L — — partial R²: 0.00085 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015377 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cerebral peduncle R — — partial R²: 0.00101 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015378 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Retrolenticular part of internal capsule R — — partial R²: 0.00097 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015379 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: External capsule R — — partial R²: 0.00074 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015380 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cingulum (cingulate gyrus) R — — partial R²: 0.00121 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015381 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cingulum (cingulate gyrus) L — — partial R²: 0.0008 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015382 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior longitudinal fasciculus R — — partial R²: 0.00107 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015383 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior longitudinal fasciculus L — — partial R²: 0.00105 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015384 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior fronto-occipital fasciculus R — — partial R²: 0.00085 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015385 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cingulum (cingulate gyrus) R — — partial R²: 0.00137 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015386 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Inferior fronto-occipital fasciculus R — — partial R²: 0.00072 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015387 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_11 — — partial R²: 0.00121 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015388 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_16 — — partial R²: 0.00091 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015389 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_24 — — partial R²: 0.00139 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015390 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_36 — — partial R²: 0.00078 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015391 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_55 — — partial R²: 0.0009 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015392 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_66 — — partial R²: 0.00094 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015393 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_68 — — partial R²: 0.00095 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015395 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_83 — — partial R²: 0.00119 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015396 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_90 — — partial R²: 0.00092 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015397 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_91 — — partial R²: 0.00087 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015398 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_123 — — partial R²: 0.00084 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015399 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_136 — — partial R²: 0.00072 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015400 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_137 — — partial R²: 0.0009 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015401 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_142 — — partial R²: 0.00098 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015402 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_161 — — partial R²: 0.00098 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015403 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_175 — — partial R²: 0.00071 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015404 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_189 — — partial R²: 0.00126 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015405 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_191 — — partial R²: 0.0033 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015406 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_199 — — partial R²: 0.00085 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015028 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00043 age, PCs1-3 —
PPM015029 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 8e-05 age, PCs1-3 —
PPM015030 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 2e-05 age, PCs1-3 —
PPM015031 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00023 age, PCs1-3 —
PPM015032 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 3e-05 age, PCs1-3 —
PPM015041 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 1.46e-06 age, PCs1-3 —
PPM015004 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 6e-05 age, PCs1-3 —
PPM015012 PGS002785
(SCZ_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00682 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015042 PGS002785
(SCZ_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00038 age, PCs1-3 —
PPM015053 PGS002785
(SCZ_SDPR)
 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00399 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015394 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_69 — — partial R²: 0.00078 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015407 PGS002785
(SCZ_SDPR)
 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_206 — — partial R²: 0.00124 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000237 Schizophrenia case subjects had two or more ICD codes included in phecode 295.1 —
[
  • 110 cases
  • , 33,584 controls
]
,
46.0 % Male samples
 Mean = 57.9 years
Sd = 20.0 years		 European — BioVU Vanderbilt University Medical Center (VUMC) biobank (BioVU)
PSS000238 Psychosis case subjects were identified with phecode 295 —
[
  • 451 cases
  • , 33,243 controls
]
,
46.0 % Male samples
 Mean = 57.9 years
Sd = 20.0 years		 European — BioVU Vanderbilt University Medical Center (VUMC) biobank (BioVU)
PSS000239 Schizophrenia case subjects had two or more ICD codes included in phecode 295.1 —
[
  • 211 cases
  • , 44,225 controls
]
,
41.0 % Male samples
 Mean = 60.2 years
Sd = 16.9 years		 European — MyCode Geisinger Health System (GHS)
PSS000240 Psychosis case subjects were identified with phecode 295 —
[
  • 499 cases
  • , 43,937 controls
]
,
41.0 % Male samples
 Mean = 60.2 years
Sd = 16.9 years		 European — MyCode Geisinger Health System (GHS)
PSS000241 Schizophrenia case subjects had two or more ICD codes included in phecode 295.1 —
[
  • 53 cases
  • , 9,516 controls
]
,
48.0 % Male samples
 Mean = 57.2 years
Sd = 19.8 years		 European — BioMe BioMe Biobank at the Mount Sinai School of Medicine (MSSM)
PSS000243 Schizophrenia case subjects had two or more ICD codes included in phecode 295.1 —
[
  • 148 cases
  • , 18,313 controls
]
,
46.0 % Male samples
 Mean = 58.5 years
Sd = 16.4 years		 European — PHB Partners HealthCare System (PHS) biobank
PSS000244 Psychosis case subjects were identified with phecode 295 —
[
  • 385 cases
  • , 18,076 controls
]
,
46.0 % Male samples
 Mean = 58.5 years
Sd = 16.4 years		 European — PHB Partners HealthCare System (PHS) biobank
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009952 imaging-derived phenotypes (IDPs) generated by an image-processing pipeline developed and ran on behalf of the UKB — 10,343 individuals,
0.0 % Male samples
 Mean = 63.13 years
Sd = 7.3 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —
PSS009954 imaging-derived phenotypes (IDPs) generated by an image-processing pipeline developed and ran on behalf of the UKB — 11,180 individuals,
100.0 % Male samples
 Mean = 64.6 years
Sd = 7.57 years		 European — UKB —