PGS Publication: PGP000845

Publication Information (EuropePMC)
Title Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch.
PubMed ID 38820342(Europe PMC)
doi 10.1371/journal.pone.0303446
Publication Date May 31, 2024
Journal PLoS One
Author(s) Cao R, Schladt DP, Dorr C, Matas AJ, Oetting WS, Jacobson PA, Israni A, Chen J, Guan W.
Released in PGS Catalog: Aug. 26, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019955
(PRS1308_AR)
 PGP000845 |
Cao R et al. PLoS One (2024)
 Acute rejection after kidney transplantation renal transplant outcome measurement 1,308
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019955/ScoringFiles/PGS019955.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038150 PGS019955
(PRS1308_AR)
 PSS013842|
European Ancestry|
704 individuals
 PGP000845 |
Cao R et al. PLoS One (2024)
 Reported Trait: Acute rejection after kidney transplantation HR: 1.54 [1.07, 2.22] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013842 — — 704 individuals,
53.0 % Male samples
 — European — GEN-03 —