Polygenic Score (PGS) ID: PGS012572

Predicted Trait
Reported Trait Omega-3 fatty acids to total fatty acids percentage
Mapped Trait(s) fatty acid amount (OBA_VT0010046)
Released in PGS Catalog: Sept. 17, 2026
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Score Details

Score Construction
PGS Name Omega_3_pct_PplusT
Development Method
Name Pruning and Thresholding (P+T)
Parameters We generated an in-sample LD reference from 239,268 UKB participants of European ancestry. Functional annotations were obtained from the S-LDSC baseline model 2.2.
Variants
Original Genome Build GRCh37
Number of Variants 163
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000809
Citation (link to publication) Xu H et al. Clin Nutr (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 88.4%
South Asian: 8.3%
East Asian: 3.3%
136,016 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • East Asian
  • African
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90301960
Europe PMC: 38448586
 4,435 individuals East Asian Multiple
GWAS Catalog: GCST90301960
Europe PMC: 38448586
 11,340 individuals South Asian Multiple
GWAS Catalog: GCST90301960
Europe PMC: 38448586
 120,241 individuals European Multiple

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030719 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of omega-3 fatty acids to total fatty acids percentage β: 0.26668 — R²: 0.06499 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012262 — — 8,237 individuals — Central Asian, South Asian — UKB —
PSS012262 — — 6,323 individuals — African unspecified — UKB —
PSS012262 — — 416,315 individuals — European — UKB —
PSS012262 — — 2,571 individuals — East Asian — UKB —