PGS Publication: PGP000809

Publication Information (EuropePMC)
Title Polygenic predisposition modifies the associations of fish oil supplementation with circulating omega-3 fatty acids: A cross-sectional gene-diet interaction study.
PubMed ID 42721579(Europe PMC)
doi 10.1016/j.clnu.2026.106774
Publication Date Aug. 28, 2026
Journal Clin Nutr
Author(s) Xu H, Yu G, Lu Y, Fuller H, Song S, Shen Y, Chiang CWK, Darst BF, Ye K.
Released in PGS Catalog: Sept. 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012567
(Omega_3_sBayesRC)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Omega-3 fatty acids omega-3 polyunsaturated fatty acid measurement 13,083,387
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012567/ScoringFiles/PGS012567.txt.gz
PGS012568
(Omega_3_pct_sBayesRC)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Omega-3 fatty acids to total fatty acids percentage fatty acid amount 13,083,387
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012568/ScoringFiles/PGS012568.txt.gz
PGS012570
(DHA_pct_PplusT)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Docosahexaenoic acid to total fatty acids percentage docosahexaenoic acid to total fatty acids percentage 110
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012570/ScoringFiles/PGS012570.txt.gz
PGS012572
(Omega_3_pct_PplusT)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Omega-3 fatty acids to total fatty acids percentage fatty acid amount 163
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012572/ScoringFiles/PGS012572.txt.gz
PGS012571
(Omega_3_PplusT)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Omega-3 fatty acids omega-3 polyunsaturated fatty acid measurement 214
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012571/ScoringFiles/PGS012571.txt.gz
PGS012565
(DHA_sBayesRC)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Docosahexaenoic acid docosahexaenoic acid measurement 13,083,387
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012565/ScoringFiles/PGS012565.txt.gz
PGS012566
(DHA_pct_sBayesRC)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Docosahexaenoic acid to total fatty acids percentage docosahexaenoic acid to total fatty acids percentage 13,083,387
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012566/ScoringFiles/PGS012566.txt.gz
PGS012569
(DHA_PplusT)
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Docosahexaenoic acid docosahexaenoic acid measurement 179
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012569/ScoringFiles/PGS012569.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030714 PGS012567
(Omega_3_sBayesRC)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of omega-3 fatty acids β: 0.30328 — R²: 0.11093 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030715 PGS012568
(Omega_3_pct_sBayesRC)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of omega-3 fatty acids to total fatty acids percentage β: 0.28245 — R²: 0.10352 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030716 PGS012569
(DHA_PplusT)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of docosahexaenoic acid β: 0.23465 — R²: 0.05085 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030717 PGS012570
(DHA_pct_PplusT)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of docosahexaenoic acid totTotal fatty acids percentage β: 0.18474 — R²: 0.03233 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030718 PGS012571
(Omega_3_PplusT)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of omega-3 fatty acids β: 0.27961 — R²: 0.06678 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030719 PGS012572
(Omega_3_pct_PplusT)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of omega-3 fatty acids to total fatty acids percentage β: 0.26668 — R²: 0.06499 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030712 PGS012565
(DHA_sBayesRC)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of docosahexaenoic acid β: 0.24415 — R²: 0.07802 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —
PPM030713 PGS012566
(DHA_pct_sBayesRC)
 PSS012262|
Multi-ancestry (including European)|
433,446 individuals
 PGP000809 |
Xu H et al. Clin Nutr (2026)
 Reported Trait: Circulating level of docosahexaenoic acid totTotal fatty acids percentage β: 0.19824 — R²: 0.05337 sex, age when attended assessment centre, interaction between sex and age, body mass index (BMI), Townsend index (TSI), smoking status, alcohol drinking status, physical activity, and statin use —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012262 — — 8,237 individuals — Central Asian, South Asian — UKB —
PSS012262 — — 6,323 individuals — African unspecified — UKB —
PSS012262 — — 416,315 individuals — European — UKB —
PSS012262 — — 2,571 individuals — East Asian — UKB —