Polygenic Score (PGS) ID: PGS018411

Predicted Trait
Reported Trait Hypertension
Mapped Trait(s) Hypertension (HP_0000822)
Additional Trait Information Multi-latent polygenic score: LASSO combination of the 49 cardiac-MRI latent PRS to predict hypertension.
Released in PGS Catalog: July 15, 2026
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Score Details

Score Construction
PGS Name MultiPRS_hypertension
Development Method
Name LASSO (L1-penalised logistic regression)
Parameters LASSO combination of the 49 individual latent-phenotype PRS (scikit-learn LogisticRegressionCV, L1 penalty, saga solver, stratified 5-fold CV). The scoring file contains the collapsed per-variant weights of the genetic (PRS) component only; model covariates (age, sex, body surface area, 20 genetic PCs) are applied separately and are NOT part of the scoring file.
Variants
Original Genome Build GRCh37
Number of Variants 1,105,536
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000826
Citation (link to publication) Ometto S et al. Nat Commun (2026)
Ancestry Distribution
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

No sample information available.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036545 PSS012301|
European Ancestry|
75,251 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Prevalent Hypertension OR: 3.14 AUROC: 0.694 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1429); DeLong p=1.782553870375481e-14. Sex='Both' (male/female strata also in Suppl. Data 27).
PPM036546 PSS012302|
European Ancestry|
26,663 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Incident Hypertension (1-10 yr) HR: 1.04 [1.02, 1.05]
OR: 2.12		 AUROC: 0.6336 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.7529); HR per SD of PRS from Cox model (col D); DeLong p=0.4962699408776705. Sex='Both'.
PPM036547 PSS012303|
European Ancestry|
111,853 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Hypertension OR: 2.98 AUROC: 0.7053 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.0932); DeLong p=2.275480499194408e-13. Sex='Both'.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012302 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 26,663 individuals — European — UKB —
PSS012303 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 111,853 individuals — European — UKB —
PSS012301 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 75,251 individuals — European — UKB —