Trait: Hypertension

Trait Information
Identifier HP_0000822
Description The presence of chronic increased pressure in the systemic arterial system.
Trait category
Cardiovascular disease
Synonyms 3 synonyms
  • Arterial hypertension
  • High blood pressure
  • Systemic hypertension

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018411
(MultiPRS_hypertension)
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Hypertension Hypertension 1,105,536
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018411/ScoringFiles/PGS018411.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036545 PGS018411
(MultiPRS_hypertension)
 PSS012301|
European Ancestry|
75,251 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Prevalent Hypertension OR: 3.14 AUROC: 0.694 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1429); DeLong p=1.782553870375481e-14. Sex='Both' (male/female strata also in Suppl. Data 27).
PPM036546 PGS018411
(MultiPRS_hypertension)
 PSS012302|
European Ancestry|
26,663 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Incident Hypertension (1-10 yr) HR: 1.04 [1.02, 1.05]
OR: 2.12		 AUROC: 0.6336 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=0.7529); HR per SD of PRS from Cox model (col D); DeLong p=0.4962699408776705. Sex='Both'.
PPM036547 PGS018411
(MultiPRS_hypertension)
 PSS012303|
European Ancestry|
111,853 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Hypertension OR: 2.98 AUROC: 0.7053 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.0932); DeLong p=2.275480499194408e-13. Sex='Both'.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012302 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 26,663 individuals — European — UKB —
PSS012303 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 111,853 individuals — European — UKB —
PSS012301 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 75,251 individuals — European — UKB —