Trait: ototoxicity

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006951
Description damage to the ear, specifically the cochlea or auditory nerve as a result of some toxic stimulus, eg from a drug. Ototoxicity can result in hearing loss.
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018415
(pgscio)
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 cisplatin-induced ototoxicity (CIO) ototoxicity,
response to cisplatin		 138,670
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018415/ScoringFiles/PGS018415.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036592 PGS018415
(pgscio)
 PSS012317|
Multi-ancestry (including European)|
390 individuals
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Reported Trait: cisplatin-induced ototoxicity — — R²: 0.041
p-value: 6e-05		 — —
PPM036594 PGS018415
(pgscio)
 PSS012318|
Ancestry Not Reported|
238 individuals
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Reported Trait: cisplatin-induced ototoxicity — AUROC: 0.732 [0.668, 0.797] R²: 0.024
p-value: 0.043		 age at diagnosis , protocol (SJMB96 or SJMB03) , 10 principal components , craniospinal irradiation dose (CSI dose)*score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012317 — —
[
  • 168 cases
  • , 222 controls
]
,
46.0 % Male samples
 — African American or Afro-Caribbean, European, Hispanic or Latin American 92% European and 8% non-European ancestry (African-American/African-Caribbean and Latin American) PCL —
PSS012318 — —
[
  • 93 cases
  • , 145 controls
]
,
62.0 % Male samples
 — Not reported — NR —