PGS Catalog - depressive symptom measurement [EFO:0007006] (Polygenic Trait)

Trait: depressive symptom measurement

Experimental Factor Ontology (EFO) Information
Identifier	EFO_0007006
Description	quantification of the existence and severity of depressive symptoms, usually via a questionnaire such as the Center for Epidemiological Studies Depression Scale (CES-D)
Trait category	Other measurement

Associated Polygenic Score(s)

Polygenic Score (PGS) ID	PGS Name	PGS Publication (PGP) ID	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	PGS Scoring File (FTP Link)
PGS000144	SelfRepDep	PGP000068 Cai N et al. Nat Genet (2020)	Self-reported depression or depression symptoms	self-reported trait depressive symptom measurement	21,828	http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000144/ScoringFiles/PGS000144.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM ID)	Evaluated Score	PGS Sample Set ID (PSS ID)	Performance Source	Trait	PGS Effect Sizes (per SD change)	PGS Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM000436	PGS000144 (SelfRepDep)	PSS000250	PGP000068 Cai N et al. Nat Genet (2020)	Reported Trait: Major Depressive Disorder status	—	AUROC: 0.51641	R²: 0.00117	Cohort	—

Evaluated Samples

PGS Sample Set ID (PSS ID)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS000250	—	—	36,709 individuals [ 14,696 cases , 22,013 controls ]	—	European	—	15 cohorts BOMA ,CoLaus ,Edinburgh ,GenPOD ,GenRED ,MARS ,MPIP ,NESDA ,QIMR ,RADIANT ,RS ,SHIP ,STAR*D ,TwinGene ,i2b2	Part of PGC29 (PMID: 29700475)