Trait: obstructive sleep apnea syndrome

Trait Information
Identifier MONDO_0007147
Description Cessation of air flow during sleep due to upper airway obstruction. [NCIT: P378]
Trait category
Other trait
Synonyms 13 synonyms
  • Apneas, obstructive sleep
  • OSAHS
  • apnea, obstructive sleep
  • obstructive sleep Apneas
  • obstructive sleep apnea
  • obstructive sleep apnea syndrome
  • sleep Apneas, obstructive
  • sleep apnea hypopnea syndrome
  • sleep apnea syndrome, obstructive
  • syndrome, obstructive sleep apnea
  • syndrome, sleep apnea, obstructive
  • syndrome, upper airway resistance, sleep apnea
  • upper airway resistance sleep apnea syndrome

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003479
(LDPred2_SleepApnea)
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Obstructive sleep apnea obstructive sleep apnea syndrome 836,839
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003479/ScoringFiles/PGS003479.txt.gz
PGS003857
(GRS18_BMIunadj)
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Obstructive sleep apnea obstructive sleep apnea syndrome 18
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003857/ScoringFiles/PGS003857.txt.gz
PGS003858
(GRS6_BMIadj)
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Obstructive sleep apnea (BMI adjusted) obstructive sleep apnea syndrome 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003858/ScoringFiles/PGS003858.txt.gz
PGS005219
(PRS_BMIadjOSA)
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Obstructive sleep apnea (AdjustedBMI) obstructive sleep apnea syndrome 982,740
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005219/ScoringFiles/PGS005219.txt.gz
PGS005220
(PRS_BMIunadjOSA)
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Obstructive sleep apnea (UnadjustedBMI) obstructive sleep apnea syndrome 984,184
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005220/ScoringFiles/PGS005220.txt.gz
PGS012520
(OSA_bmi_unadj)
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Obstructive sleep apnea obstructive sleep apnea syndrome 17
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012520/ScoringFiles/PGS012520.txt.gz
PGS012521
(OSA_bmi_adj)
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Obstructive sleep apnea (adjusted for BMI) obstructive sleep apnea syndrome 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012521/ScoringFiles/PGS012521.txt.gz
PGS012528
(OSA_bmi_unadj_LD)
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Obstructive sleep apnea obstructive sleep apnea syndrome 307,286
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012528/ScoringFiles/PGS012528.txt.gz
PGS012529
(OSA_bmi_adj_LD)
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Obstructive sleep apnea (adjusted for BMI) obstructive sleep apnea syndrome 323,621
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012529/ScoringFiles/PGS012529.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017318 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: DBP β: 0.038 (0.093) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017319 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Eosinophils count β: 0.003 (0.002) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017320 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: FEV1/FVC ratio β: -0.035 (0.06) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017321 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Fasting insulin β: 0.156 (0.091) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017322 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HbA1c β: 0.291 (0.122) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017323 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Hematocrit β: 0.039 (0.031) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017324 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Hemoglobin β: 0.014 (0.011) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017325 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-B β: 1.851 (1.169) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017326 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-IR β: 0.051 (0.03) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017327 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Heart rate β: 0.038 (0.106) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017328 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Insomnia β: 0.015 (0.049) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017329 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: LDL β: -0.358 (0.336) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017330 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Lymphocyte count β: 0.002 (0.007) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017331 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Mean arterial pressure β: 0.011 (0.102) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017333 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: RBC β: 0.003 (0.003) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017334 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Sleep duration β: 0.0 (0.013) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017335 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Total cholesterol β: -0.324 (0.391) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017336 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Triglycerides β: 0.725 (0.93) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017337 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: WBC β: 0.006 (0.018) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017338 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Waist hip ratio β: 0.002 (0.001) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017339 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: FEV1/FVC ratio β: 0.002 (0.018) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017380 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: DBP in obsese β: -0.084 (0.148) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017381 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: DBP in non-obsese β: 0.116 (0.118) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017382 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Fasting insulin in obsese β: 0.201 (0.161) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017383 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Fasting insulin in non-obsese β: 0.175 (0.089) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017384 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HbA1c in obsese β: 0.052 (0.197) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017385 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HbA1c in non-obsese β: 0.488 (0.151) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017386 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-B in obsese β: 0.724 (2.105) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017387 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-B in non-obsese β: 1.664 (1.084) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017388 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-IR in obsese β: 0.076 (0.057) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017389 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-IR in non-obsese β: 0.062 (0.029) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017390 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Waist hip ratio in obsese β: 0.002 (0.001) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017391 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Waist hip ratio in non-obsese β: 0.001 (0.001) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017332 PGS003479
(LDPred2_SleepApnea)
 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Pulse pressure β: -0.073 (0.104) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM018710 PGS003857
(GRS18_BMIunadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI adjusted obstructive sleep apnea β: 0.014 (0.017) AUROC: 0.77 [0.75, 0.78] — BMI, age, sex, genetic batch, PCs 1-10 —
PPM018709 PGS003857
(GRS18_BMIunadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI unadjusted obstructive sleep apnea β: 0.082 (0.016) AUROC: 0.66 [0.64, 0.67] — age, sex, genetic batch, PCs 1-10 —
PPM018711 PGS003858
(GRS6_BMIadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI unadjusted obstructive sleep apnea β: 0.048 (0.015) AUROC: 0.62 [0.61, 0.64] — age, sex, genetic batch, PCs 1-10 —
PPM018712 PGS003858
(GRS6_BMIadj)
 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI adjusted obstructive sleep apnea β: 0.066 (0.017) AUROC: 0.77 [0.76, 0.79] — BMI, age, sex, genetic batch, PCs 1-10 —
PPM022619 PGS005219
(PRS_BMIadjOSA)
 PSS012043|
Multi-ancestry (including European)|
21,975 individuals
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Reported Trait: Obstructive sleep apnea OR: 1.98 [1.74, 2.24] AUROC: 0.79 — age, sex, self-reported race/ethnicity , BMI and 11PCs —
PPM022620 PGS005220
(PRS_BMIunadjOSA)
 PSS012043|
Multi-ancestry (including European)|
21,975 individuals
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Reported Trait: Obstructive sleep apnea OR: 1.53 [1.39, 1.68] AUROC: 0.79 — age, sex, self-reported race/ethnicity , BMI and 11PCs —
PPM030578 PGS012520
(OSA_bmi_unadj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.004 (0.025) — — sex, age, age^2, BMI, 11 genetic PCs Effect estimate corresponds to PRS per SD adjusted for genetic PCs.
PPM030579 PGS012520
(OSA_bmi_unadj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.003 (0.026) — — sex, age, age^2, BMI, global ancestry proportions Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions.
PPM030580 PGS012520
(OSA_bmi_unadj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.003 (0.026) — — sex, age, age^2, BMI, global ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS).
PPM030581 PGS012520
(OSA_bmi_unadj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.004 (0.026) — — sex, age, age^2, BMI, local ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS).
PPM030574 PGS012521
(OSA_bmi_adj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.07 (0.024) — — sex, age, age^2, BMI, BMI^2, 11 genetic PCs Effect estimate corresponds to PRS per SD adjusted for genetic PCs.
PPM030575 PGS012521
(OSA_bmi_adj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.069 (0.024) — — sex, age, age^2, BMI, BMI^2, global ancestry proportions Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions.
PPM030576 PGS012521
(OSA_bmi_adj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.068 (0.024) — — sex, age, age^2, BMI, BMI^2, global ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS).
PPM030577 PGS012521
(OSA_bmi_adj)
 PSS012199|
Multi-ancestry (including European)|
16,422 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.069 (0.024) — — sex, age, age^2, BMI, BMI^2, local ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS).
PPM030605 PGS012528
(OSA_bmi_unadj_LD)
 PSS012198|
Multi-ancestry (including European)|
15,829 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.174 (0.044) — — sex, age, age^2, BMI, 11 genetic PCs Effect estimate corresponds to PRS per SD adjusted for genetic PCs.
PPM030606 PGS012528
(OSA_bmi_unadj_LD)
 PSS012198|
Multi-ancestry (including European)|
15,829 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.166 (0.044) — — sex, age, age^2, BMI, global ancestry proportions Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions.
PPM030607 PGS012528
(OSA_bmi_unadj_LD)
 PSS012198|
Multi-ancestry (including European)|
15,829 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea β: 0.167 (0.044) — — sex, age, age^2, BMI, global ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS).
PPM030602 PGS012529
(OSA_bmi_adj_LD)
 PSS012198|
Multi-ancestry (including European)|
15,829 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.24 (0.05) — — sex, age, age^2, BMI, BMI^2, 11 genetic PCs Effect estimate corresponds to PRS per SD adjusted for genetic PCs.
PPM030603 PGS012529
(OSA_bmi_adj_LD)
 PSS012198|
Multi-ancestry (including European)|
15,829 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.232 (0.05) — — sex, age, age^2, BMI, BMI^2, global ancestry proportions Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions.
PPM030604 PGS012529
(OSA_bmi_adj_LD)
 PSS012198|
Multi-ancestry (including European)|
15,829 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Obstructive sleep apnea (adjusted for BMI) β: 0.225 (0.05) — — sex, age, age^2, BMI, BMI^2, global ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS).

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012199 — — 3,222 individuals — African American or Afro-Caribbean — OOA —
PSS012199 — — 7,137 individuals — Hispanic or Latin American — OOA —
PSS012199 — — 228 individuals — Asian unspecified — OOA —
PSS012198 — — 5,469 individuals — European — OOA —
PSS012198 — — 3,029 individuals — African American or Afro-Caribbean — OOA —
PSS012043 — —
[
  • 4,463 cases
  • , 17,512 controls
]
,
47.0 % Male samples
 Mean = 53.0 years European, African American or Afro-Caribbean, East Asian, Hispanic or Latin American — OOA —
PSS012198 — — 7,103 individuals — Hispanic or Latin American — OOA —
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS-SOL —
PSS012198 — — 228 individuals — Asian unspecified — OOA —
PSS012199 — — 5,835 individuals — European — OOA —
PSS011076 — — 2,023 individuals,
37.4 % Male samples
 Mean = 53.16 years
Sd = 16.23 years		 African unspecified — MGBB —
PSS011076 — — 932 individuals,
41.8 % Male samples
 Mean = 47.0 years
Sd = 15.67 years		 Asian unspecified — MGBB —
PSS011076 — — 34,764 individuals,
46.7 % Male samples
 Mean = 60.62 years
Sd = 16.83 years		 European — MGBB —
PSS011076 — — 1,182 individuals,
31.3 % Male samples
 Mean = 52.29 years
Sd = 16.56 years		 Hispanic or Latin American — MGBB —
PSS011076 — — 1,292 individuals,
46.8 % Male samples
 Mean = 52.08 years
Sd = 18.42 years		 Not reported — MGBB —