Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018658
(TPMI_241.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic uninodular goiter nontoxic goiter 983,778
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018658/ScoringFiles/PGS018658.txt.gz
PGS018659
(TPMI_241.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic uninodular goiter nontoxic goiter 1,006,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018659/ScoringFiles/PGS018659.txt.gz
PGS018660
(TPMI_241.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic multinodular goiter nontoxic goiter 610
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018660/ScoringFiles/PGS018660.txt.gz
PGS018661
(TPMI_241.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic multinodular goiter nontoxic goiter 275,929
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018661/ScoringFiles/PGS018661.txt.gz
PGS018662
(TPMI_241.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic multinodular goiter nontoxic goiter 45,575
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018662/ScoringFiles/PGS018662.txt.gz
PGS018663
(TPMI_241.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic multinodular goiter nontoxic goiter 983,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018663/ScoringFiles/PGS018663.txt.gz
PGS018664
(TPMI_241.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nontoxic multinodular goiter nontoxic goiter 142,675
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018664/ScoringFiles/PGS018664.txt.gz
PGS018665
(TPMI_242_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyrotoxicosis with or without goiter thyrotoxicosis 1,343
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018665/ScoringFiles/PGS018665.txt.gz
PGS018666
(TPMI_242_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyrotoxicosis with or without goiter thyrotoxicosis 348,159
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018666/ScoringFiles/PGS018666.txt.gz
PGS018667
(TPMI_242_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyrotoxicosis with or without goiter thyrotoxicosis 66,615
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018667/ScoringFiles/PGS018667.txt.gz
PGS018668
(TPMI_242_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyrotoxicosis with or without goiter thyrotoxicosis 983,779
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018668/ScoringFiles/PGS018668.txt.gz
PGS018669
(TPMI_242_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyrotoxicosis with or without goiter thyrotoxicosis 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018669/ScoringFiles/PGS018669.txt.gz
PGS018670
(TPMI_242_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyrotoxicosis with or without goiter thyrotoxicosis 151,393
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018670/ScoringFiles/PGS018670.txt.gz
PGS018671
(TPMI_242.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Graves disease Graves disease 415
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018671/ScoringFiles/PGS018671.txt.gz
PGS018672
(TPMI_242.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Graves disease Graves disease 220,843
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018672/ScoringFiles/PGS018672.txt.gz
PGS018673
(TPMI_242.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Graves disease Graves disease 37,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018673/ScoringFiles/PGS018673.txt.gz
PGS018674
(TPMI_242.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Graves disease Graves disease 983,772
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018674/ScoringFiles/PGS018674.txt.gz
PGS018675
(TPMI_242.1_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Graves disease Graves disease 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018675/ScoringFiles/PGS018675.txt.gz
PGS018676
(TPMI_242.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Graves disease Graves disease 975,251
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018676/ScoringFiles/PGS018676.txt.gz
PGS018677
(TPMI_244_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism hypothyroidism 217
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018677/ScoringFiles/PGS018677.txt.gz
PGS018678
(TPMI_244_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism hypothyroidism 939,824
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018678/ScoringFiles/PGS018678.txt.gz
PGS018679
(TPMI_244_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism hypothyroidism 24,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018679/ScoringFiles/PGS018679.txt.gz
PGS018680
(TPMI_244_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism hypothyroidism 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018680/ScoringFiles/PGS018680.txt.gz
PGS018681
(TPMI_244_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism hypothyroidism 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018681/ScoringFiles/PGS018681.txt.gz
PGS018682
(TPMI_244_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism hypothyroidism 966,339
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018682/ScoringFiles/PGS018682.txt.gz
PGS018683
(TPMI_244.4_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism NOS hypothyroidism 493
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018683/ScoringFiles/PGS018683.txt.gz
PGS018684
(TPMI_244.4_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism NOS hypothyroidism 939,822
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018684/ScoringFiles/PGS018684.txt.gz
PGS018685
(TPMI_244.4_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism NOS hypothyroidism 414,367
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018685/ScoringFiles/PGS018685.txt.gz
PGS018686
(TPMI_244.4_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism NOS hypothyroidism 983,778
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018686/ScoringFiles/PGS018686.txt.gz
PGS018687
(TPMI_244.4_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism NOS hypothyroidism 1,071,403
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018687/ScoringFiles/PGS018687.txt.gz
PGS018688
(TPMI_244.4_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypothyroidism NOS hypothyroidism 951,538
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018688/ScoringFiles/PGS018688.txt.gz
PGS018689
(TPMI_245_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroiditis thyroiditis 2,574
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018689/ScoringFiles/PGS018689.txt.gz
PGS018690
(TPMI_245_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroiditis thyroiditis 939,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018690/ScoringFiles/PGS018690.txt.gz
PGS018691
(TPMI_245_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroiditis thyroiditis 38,746
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018691/ScoringFiles/PGS018691.txt.gz
PGS018692
(TPMI_245_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroiditis thyroiditis 983,779
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018692/ScoringFiles/PGS018692.txt.gz
PGS018693
(TPMI_245_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroiditis thyroiditis 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018693/ScoringFiles/PGS018693.txt.gz
PGS018694
(TPMI_245_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroiditis thyroiditis 976,726
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018694/ScoringFiles/PGS018694.txt.gz
PGS018695
(TPMI_245.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic thyroiditis Hashimoto thyroiditis 171
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018695/ScoringFiles/PGS018695.txt.gz
PGS018696
(TPMI_245.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic thyroiditis Hashimoto thyroiditis 939,816
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018696/ScoringFiles/PGS018696.txt.gz
PGS018697
(TPMI_245.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic thyroiditis Hashimoto thyroiditis 392,668
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018697/ScoringFiles/PGS018697.txt.gz
PGS018698
(TPMI_245.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic thyroiditis Hashimoto thyroiditis 983,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018698/ScoringFiles/PGS018698.txt.gz
PGS018699
(TPMI_245.2_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic thyroiditis Hashimoto thyroiditis 1,071,404
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018699/ScoringFiles/PGS018699.txt.gz
PGS018700
(TPMI_245.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic thyroiditis Hashimoto thyroiditis 979,446
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018700/ScoringFiles/PGS018700.txt.gz
PGS018701
(TPMI_245.21_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic lymphocytic thyroiditis Hashimoto thyroiditis 190
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018701/ScoringFiles/PGS018701.txt.gz
PGS018702
(TPMI_245.21_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic lymphocytic thyroiditis Hashimoto thyroiditis 318,664
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018702/ScoringFiles/PGS018702.txt.gz
PGS018703
(TPMI_245.21_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic lymphocytic thyroiditis Hashimoto thyroiditis 394,827
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018703/ScoringFiles/PGS018703.txt.gz
PGS018704
(TPMI_245.21_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic lymphocytic thyroiditis Hashimoto thyroiditis 983,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018704/ScoringFiles/PGS018704.txt.gz
PGS018705
(TPMI_245.21_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic lymphocytic thyroiditis Hashimoto thyroiditis 1,071,405
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018705/ScoringFiles/PGS018705.txt.gz
PGS018706
(TPMI_245.21_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic lymphocytic thyroiditis Hashimoto thyroiditis 1,005,256
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018706/ScoringFiles/PGS018706.txt.gz
PGS018707
(TPMI_246_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other disorders of thyroid thyroid gland disorder 3,470
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018707/ScoringFiles/PGS018707.txt.gz
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