Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS018669
(TPMI_242_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Thyrotoxicosis with or without goiter thyrotoxicosis 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018669/ScoringFiles/PGS018669.txt.gz
PGS018670
(TPMI_242_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Thyrotoxicosis with or without goiter thyrotoxicosis 151,393
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018670/ScoringFiles/PGS018670.txt.gz
PGS018671
(TPMI_242.1_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Graves disease Graves disease 415
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018671/ScoringFiles/PGS018671.txt.gz
PGS018672
(TPMI_242.1_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Graves disease Graves disease 220,843
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018672/ScoringFiles/PGS018672.txt.gz
PGS018673
(TPMI_242.1_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Graves disease Graves disease 37,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018673/ScoringFiles/PGS018673.txt.gz
PGS018674
(TPMI_242.1_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Graves disease Graves disease 983,772
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018674/ScoringFiles/PGS018674.txt.gz
PGS018675
(TPMI_242.1_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Graves disease Graves disease 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018675/ScoringFiles/PGS018675.txt.gz
PGS018676
(TPMI_242.1_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Graves disease Graves disease 975,251
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018676/ScoringFiles/PGS018676.txt.gz
PGS018677
(TPMI_244_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism hypothyroidism 217
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018677/ScoringFiles/PGS018677.txt.gz
PGS018678
(TPMI_244_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism hypothyroidism 939,824
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018678/ScoringFiles/PGS018678.txt.gz
PGS018679
(TPMI_244_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism hypothyroidism 24,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018679/ScoringFiles/PGS018679.txt.gz
PGS018680
(TPMI_244_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism hypothyroidism 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018680/ScoringFiles/PGS018680.txt.gz
PGS018681
(TPMI_244_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism hypothyroidism 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018681/ScoringFiles/PGS018681.txt.gz
PGS018682
(TPMI_244_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism hypothyroidism 966,339
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018682/ScoringFiles/PGS018682.txt.gz
PGS018683
(TPMI_244.4_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism NOS hypothyroidism 493
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018683/ScoringFiles/PGS018683.txt.gz
PGS018684
(TPMI_244.4_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism NOS hypothyroidism 939,822
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018684/ScoringFiles/PGS018684.txt.gz
PGS018685
(TPMI_244.4_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism NOS hypothyroidism 414,367
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018685/ScoringFiles/PGS018685.txt.gz
PGS018686
(TPMI_244.4_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism NOS hypothyroidism 983,778
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018686/ScoringFiles/PGS018686.txt.gz
PGS018687
(TPMI_244.4_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism NOS hypothyroidism 1,071,403
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018687/ScoringFiles/PGS018687.txt.gz
PGS018688
(TPMI_244.4_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Hypothyroidism NOS hypothyroidism 951,538
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018688/ScoringFiles/PGS018688.txt.gz
PGS018689
(TPMI_245_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroiditis thyroiditis 2,574
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018689/ScoringFiles/PGS018689.txt.gz
PGS018690
(TPMI_245_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroiditis thyroiditis 939,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018690/ScoringFiles/PGS018690.txt.gz
PGS018691
(TPMI_245_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroiditis thyroiditis 38,746
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018691/ScoringFiles/PGS018691.txt.gz
PGS018692
(TPMI_245_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroiditis thyroiditis 983,779
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018692/ScoringFiles/PGS018692.txt.gz
PGS018693
(TPMI_245_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroiditis thyroiditis 1,071,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018693/ScoringFiles/PGS018693.txt.gz
PGS018694
(TPMI_245_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroiditis thyroiditis 976,726
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018694/ScoringFiles/PGS018694.txt.gz
PGS018695
(TPMI_245.2_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic thyroiditis Hashimoto thyroiditis 171
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018695/ScoringFiles/PGS018695.txt.gz
PGS018696
(TPMI_245.2_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic thyroiditis Hashimoto thyroiditis 939,816
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018696/ScoringFiles/PGS018696.txt.gz
PGS018697
(TPMI_245.2_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic thyroiditis Hashimoto thyroiditis 392,668
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018697/ScoringFiles/PGS018697.txt.gz
PGS018698
(TPMI_245.2_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic thyroiditis Hashimoto thyroiditis 983,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018698/ScoringFiles/PGS018698.txt.gz
PGS018699
(TPMI_245.2_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic thyroiditis Hashimoto thyroiditis 1,071,404
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018699/ScoringFiles/PGS018699.txt.gz
PGS018700
(TPMI_245.2_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic thyroiditis Hashimoto thyroiditis 979,446
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018700/ScoringFiles/PGS018700.txt.gz
PGS018701
(TPMI_245.21_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic lymphocytic thyroiditis Hashimoto thyroiditis 190
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018701/ScoringFiles/PGS018701.txt.gz
PGS018702
(TPMI_245.21_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic lymphocytic thyroiditis Hashimoto thyroiditis 318,664
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018702/ScoringFiles/PGS018702.txt.gz
PGS018703
(TPMI_245.21_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic lymphocytic thyroiditis Hashimoto thyroiditis 394,827
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018703/ScoringFiles/PGS018703.txt.gz
PGS018704
(TPMI_245.21_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic lymphocytic thyroiditis Hashimoto thyroiditis 983,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018704/ScoringFiles/PGS018704.txt.gz
PGS018705
(TPMI_245.21_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic lymphocytic thyroiditis Hashimoto thyroiditis 1,071,405
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018705/ScoringFiles/PGS018705.txt.gz
PGS018706
(TPMI_245.21_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Chronic lymphocytic thyroiditis Hashimoto thyroiditis 1,005,256
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018706/ScoringFiles/PGS018706.txt.gz
PGS018707
(TPMI_246_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Other disorders of thyroid thyroid gland disorder 3,470
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018707/ScoringFiles/PGS018707.txt.gz
PGS018708
(TPMI_246_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Other disorders of thyroid thyroid gland disorder 939,875
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018708/ScoringFiles/PGS018708.txt.gz
PGS018709
(TPMI_246_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Other disorders of thyroid thyroid gland disorder 23,611
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018709/ScoringFiles/PGS018709.txt.gz
PGS018710
(TPMI_246_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Other disorders of thyroid thyroid gland disorder 983,821
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018710/ScoringFiles/PGS018710.txt.gz
PGS018711
(TPMI_246_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Other disorders of thyroid thyroid gland disorder 967,487
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018711/ScoringFiles/PGS018711.txt.gz
PGS018712
(TPMI_246.2_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroid cyst dermoid cyst 287
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018712/ScoringFiles/PGS018712.txt.gz
PGS018713
(TPMI_246.2_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroid cyst dermoid cyst 237,092
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018713/ScoringFiles/PGS018713.txt.gz
PGS018714
(TPMI_246.2_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroid cyst dermoid cyst 552,969
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018714/ScoringFiles/PGS018714.txt.gz
PGS018715
(TPMI_246.2_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroid cyst dermoid cyst 983,778
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018715/ScoringFiles/PGS018715.txt.gz
PGS018716
(TPMI_246.2_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Thyroid cyst dermoid cyst 1,016,561
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018716/ScoringFiles/PGS018716.txt.gz
PGS018717
(TPMI_250_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Diabetes mellitus diabetes mellitus 47,432
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018717/ScoringFiles/PGS018717.txt.gz
PGS018718
(TPMI_250_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Diabetes mellitus diabetes mellitus 939,825
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018718/ScoringFiles/PGS018718.txt.gz