Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS018908
(TPMI_290.11_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Alzheimers disease Alzheimer disease 456,140
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018908/ScoringFiles/PGS018908.txt.gz
PGS018909
(TPMI_290.11_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Alzheimers disease Alzheimer disease 983,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018909/ScoringFiles/PGS018909.txt.gz
PGS018910
(TPMI_290.11_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Alzheimers disease Alzheimer disease 102,677
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018910/ScoringFiles/PGS018910.txt.gz
PGS018911
(TPMI_290.13_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Senile dementia dementia 6,126
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018911/ScoringFiles/PGS018911.txt.gz
PGS018912
(TPMI_290.13_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Senile dementia dementia 939,839
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018912/ScoringFiles/PGS018912.txt.gz
PGS018913
(TPMI_290.13_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Senile dementia dementia 652,894
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018913/ScoringFiles/PGS018913.txt.gz
PGS018914
(TPMI_290.13_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Senile dementia dementia 983,791
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018914/ScoringFiles/PGS018914.txt.gz
PGS018915
(TPMI_290.13_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Senile dementia dementia 942,185
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018915/ScoringFiles/PGS018915.txt.gz
PGS018916
(TPMI_291_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Other specified nonpsychotic and or transient mental disorders mental disorder 317
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018916/ScoringFiles/PGS018916.txt.gz
PGS018917
(TPMI_291_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Other specified nonpsychotic and or transient mental disorders mental disorder 373,255
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018917/ScoringFiles/PGS018917.txt.gz
PGS018918
(TPMI_291_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Other specified nonpsychotic and or transient mental disorders mental disorder 616,739
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018918/ScoringFiles/PGS018918.txt.gz
PGS018919
(TPMI_291_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Other specified nonpsychotic and or transient mental disorders mental disorder 983,789
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018919/ScoringFiles/PGS018919.txt.gz
PGS018920
(TPMI_291_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Other specified nonpsychotic and or transient mental disorders mental disorder 333,423
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018920/ScoringFiles/PGS018920.txt.gz
PGS018921
(TPMI_291.4_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Specific nonpsychotic mental disorders due to brain damage mental disorder 127
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018921/ScoringFiles/PGS018921.txt.gz
PGS018922
(TPMI_291.4_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Specific nonpsychotic mental disorders due to brain damage mental disorder 939,895
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018922/ScoringFiles/PGS018922.txt.gz
PGS018923
(TPMI_291.4_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Specific nonpsychotic mental disorders due to brain damage mental disorder 19,578
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018923/ScoringFiles/PGS018923.txt.gz
PGS018924
(TPMI_291.4_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Specific nonpsychotic mental disorders due to brain damage mental disorder 983,829
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018924/ScoringFiles/PGS018924.txt.gz
PGS018925
(TPMI_291.4_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Specific nonpsychotic mental disorders due to brain damage mental disorder 131,160
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018925/ScoringFiles/PGS018925.txt.gz
PGS018926
(TPMI_292_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Neurological disorders nervous system disorder 4
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018926/ScoringFiles/PGS018926.txt.gz
PGS018927
(TPMI_292_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Neurological disorders nervous system disorder 330,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018927/ScoringFiles/PGS018927.txt.gz
PGS018928
(TPMI_292_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Neurological disorders nervous system disorder 566,907
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018928/ScoringFiles/PGS018928.txt.gz
PGS018929
(TPMI_292_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Neurological disorders nervous system disorder 983,821
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018929/ScoringFiles/PGS018929.txt.gz
PGS018930
(TPMI_292_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Neurological disorders nervous system disorder 980,061
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018930/ScoringFiles/PGS018930.txt.gz
PGS018931
(TPMI_292.2_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Mild cognitive impairment Cognitive impairment 37,738
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018931/ScoringFiles/PGS018931.txt.gz
PGS018932
(TPMI_292.2_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Mild cognitive impairment Cognitive impairment 271,015
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018932/ScoringFiles/PGS018932.txt.gz
PGS018933
(TPMI_292.2_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Mild cognitive impairment Cognitive impairment 477,076
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018933/ScoringFiles/PGS018933.txt.gz
PGS018934
(TPMI_292.2_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Mild cognitive impairment Cognitive impairment 983,787
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018934/ScoringFiles/PGS018934.txt.gz
PGS018935
(TPMI_292.2_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Mild cognitive impairment Cognitive impairment 1,011,196
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018935/ScoringFiles/PGS018935.txt.gz
PGS018936
(TPMI_296.2_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Depression depressive disorder 230,322
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018936/ScoringFiles/PGS018936.txt.gz
PGS018937
(TPMI_296.2_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Depression depressive disorder 939,862
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018937/ScoringFiles/PGS018937.txt.gz
PGS018938
(TPMI_296.2_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Depression depressive disorder 18,793
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018938/ScoringFiles/PGS018938.txt.gz
PGS018939
(TPMI_296.2_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Depression depressive disorder 983,806
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018939/ScoringFiles/PGS018939.txt.gz
PGS018940
(TPMI_296.2_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Depression depressive disorder 961,120
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018940/ScoringFiles/PGS018940.txt.gz
PGS018941
(TPMI_300.11_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Generalized anxiety disorder generalized anxiety disorder 729,735
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018941/ScoringFiles/PGS018941.txt.gz
PGS018942
(TPMI_300.11_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Generalized anxiety disorder generalized anxiety disorder 939,863
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018942/ScoringFiles/PGS018942.txt.gz
PGS018943
(TPMI_300.11_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Generalized anxiety disorder generalized anxiety disorder 21,630
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018943/ScoringFiles/PGS018943.txt.gz
PGS018944
(TPMI_300.11_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Generalized anxiety disorder generalized anxiety disorder 983,808
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018944/ScoringFiles/PGS018944.txt.gz
PGS018945
(TPMI_300.11_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Generalized anxiety disorder generalized anxiety disorder 975,855
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018945/ScoringFiles/PGS018945.txt.gz
PGS018946
(TPMI_306_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Other mental disorder mental disorder 393,402
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018946/ScoringFiles/PGS018946.txt.gz
PGS018947
(TPMI_306_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Other mental disorder mental disorder 402,973
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018947/ScoringFiles/PGS018947.txt.gz
PGS018948
(TPMI_306_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Other mental disorder mental disorder 22,265
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018948/ScoringFiles/PGS018948.txt.gz
PGS018949
(TPMI_306_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Other mental disorder mental disorder 983,807
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018949/ScoringFiles/PGS018949.txt.gz
PGS018950
(TPMI_306_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Other mental disorder mental disorder 922,093
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018950/ScoringFiles/PGS018950.txt.gz
PGS018951
(TPMI_315_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Develomental delays and disorders specific developmental disorder 21
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018951/ScoringFiles/PGS018951.txt.gz
PGS018952
(TPMI_315_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Develomental delays and disorders specific developmental disorder 178,694
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018952/ScoringFiles/PGS018952.txt.gz
PGS018953
(TPMI_315_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Develomental delays and disorders specific developmental disorder 28,656
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018953/ScoringFiles/PGS018953.txt.gz
PGS018954
(TPMI_315_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Develomental delays and disorders specific developmental disorder 983,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018954/ScoringFiles/PGS018954.txt.gz
PGS018955
(TPMI_315_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Develomental delays and disorders specific developmental disorder 1,013,967
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018955/ScoringFiles/PGS018955.txt.gz
PGS018956
(TPMI_317_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Alcohol related disorders alcohol-related disorders 30
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018956/ScoringFiles/PGS018956.txt.gz
PGS018957
(TPMI_317_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Alcohol related disorders alcohol-related disorders 939,840
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018957/ScoringFiles/PGS018957.txt.gz