Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0003144 |
Description | Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. [EFO: 0003144] | Trait category |
Cardiovascular disease
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Synonyms |
11 synonyms
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Mapped term(s) |
12 mapped terms
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Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000709 | HC299 | PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021) | Heart failure | heart failure | 183,287 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000709/ScoringFiles/PGS000709.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001601 | PGS000709 (HC299) |
PSS000820 | PGP000128 Sinnott-Armstrong N et al. (2021) | Reported Trait: Heart failure | — | AUROC: 0.53217 | — | Age, sex, PCs(1-10) | — |
PPM001614 | PGS000709 (HC299) |
PSS000821 | PGP000128 Sinnott-Armstrong N et al. (2021) | Reported Trait: Heart failure | HR: 1.08 [1.06, 1.1] | C-index: 0.635 | — | Age as time scale, sex, batch, PCs(1-10) | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000820 | — | — | 87,413 individuals | — | European | — | UKB | — |
PSS000821 | ICD-10 I50, I11.0, I13.0 | — | [
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— | European (Finnish) |
— | FinnGen | — |