Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0004214 |
Description | Enlargement and ballooning of the vessel that supplies arterial blood to the abdomen, pelvis and legs. [NCIT: P378] | Trait category |
Cardiovascular disease
|
Synonyms |
3 synonyms
|
Mapped term(s) |
8 mapped terms
|
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000753 | PRS29_AAA | PGP000159 Klarin D et al. Circulation (2020) |
Abdominal aortic aneurysm | Abdominal Aortic Aneurysm | 29 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000753/ScoringFiles/PGS000753.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001912 | PGS000753 (PRS29_AAA) |
PSS000958 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 1.37 [1.3, 1.44] | — | — | Age, sex, PCs (1-5) | — |
PPM001913 | PGS000753 (PRS29_AAA) |
PSS000956 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 1.15 [1.07, 1.24] | — | — | Age, sex, PCs (1-5) | — |
PPM001915 | PGS000753 (PRS29_AAA) |
PSS000959 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 1.31 [1.18, 1.46] | — | — | Age, sex, PCs (1-5) | — |
PPM001917 | PGS000753 (PRS29_AAA) |
PSS000956 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 1.13 [1.04, 1.22] | — | — | Age, sex, PCs (1-5), smoking, hypertension, low-density lipoprotein cholesterol with statin adjustment, high-density lipoprotein cholesterol, triglycerides, coronary artery disease as a marker of atherosclerosis burden. | — |
PPM001918 | PGS000753 (PRS29_AAA) |
PSS000957 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 1.58 [1.25, 1.98] | — | — | Age, sex, PCs (1-5), smoking, hypertension, low-density lipoprotein cholesterol with statin adjustment, high-density lipoprotein cholesterol, triglycerides, coronary artery disease as a marker of atherosclerosis burden. | — |
PPM001914 | PGS000753 (PRS29_AAA) |
PSS000957 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 2.46 [1.46, 4.14] | — | — | Age, sex, PCs (1-5) | — |
PPM001916 | PGS000753 (PRS29_AAA) |
PSS000958 | PGP000159 Klarin D et al. Circulation (2020) |
Reported Trait: Prevalent abdominal aortic aneurysm | OR: 1.34 [1.27, 1.41] | — | — | Age, sex, PCs (1-5), smoking, hypertension, low-density lipoprotein cholesterol with statin adjustment, high-density lipoprotein cholesterol, triglycerides, coronary artery disease as a marker of atherosclerosis burden. | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000958 | Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4. Controls were defined as possessing no occurrences of the aforementioned ICD codes, as well as no occurrences of the ICD-9 codes 440 through 448 or ICD-10 codes I71 through I75, I77 through I79, or K55. | — | [ ,
92.1 % Male samples |
Mean = 63.8 years Sd = 13.7 years |
European | — | MVP | Sample is independent to the MVP sample used to identify SNPs and determine their weights |
PSS000959 | Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4. | — | [ ,
65.4 % Male samples |
Mean = 71.0 years Sd = 13.7 years |
European | — | PMB | — |
PSS000956 | Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4. Controls were defined as possessing no occurrences of the aforementioned ICD codes, as well as no occurrences of the ICD-9 codes 440 through 448 or ICD-10 codes I71 through I75, I77 through I79, or K55. | — | [ ,
86.0 % Male samples |
Mean = 56.3 years Sd = 11.8 years |
African unspecified | — | MVP | — |
PSS000957 | Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4. | — | [ ,
48.1 % Male samples |
Mean = 58.3 years Sd = 19.5 years |
European | — | IMP | — |