Trait: major depressive disorder

Trait Information
Identifier MONDO_0002009
Description An episode of depression lasting two or more weeks without an intervening episode of mania. [NCIT: P378]
Trait category
Neurological disorder
Synonyms 2 synonyms
  • single major depressive episode
  • recurrent major depression
Mapped term(s) 12 mapped terms
  • ICD9:296.20
  • ICD10:F33
  • ICD10:F32.9
  • ICD10:F32
  • DOID:1470
  • MFOMD:0000143
  • ICD9:296.3
  • SCTID:370143000
  • ICD9:296.2
  • MESH:D003865
  • ICD10:F33.9
  • ICD9:296.30

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Number of Variants PGS Scoring File (FTP Link)
PGS000138 LifetimeMDD PGP000068
Cai N et al. Nat Genet (2020)
Lifetime Major Depressive Disorder 22,274 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000138/ScoringFiles/PGS000138.txt.gz
PGS000139 MDDRecur PGP000068
Cai N et al. Nat Genet (2020)
Lifetime Major Depressive Disorder (with recurrence) 21,980 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000139/ScoringFiles/PGS000139.txt.gz
PGS000145 ICD10Dep PGP000068
Cai N et al. Nat Genet (2020)
Depression (ICD-10 defined) 21,510 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000145/ScoringFiles/PGS000145.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000437 PGS000145 (ICD10Dep) PSS000250 PGP000068
Cai N et al. (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.5251015 : 0.003198656 Cohort
PPM000430 PGS000138 (LifetimeMDD) PSS000250 PGP000068
Cai N et al. (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.5611035 : 0.018171054 Cohort
PPM000431 PGS000139 (MDDRecur) PSS000250 PGP000068
Cai N et al. (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.5487412 : 0.01097163 Cohort

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000250
[
  • 14,696 cases
  • , 22,013 controls
]
European 15 cohorts
  • BOMA
  • ,CoLaus
  • ,Edinburgh
  • ,GenPOD
  • ,GenRED
  • ,MARS
  • ,MPIP
  • ,NESDA
  • ,QIMR
  • ,RADIANT
  • ,RS
  • ,SHIP
  • ,STAR*D
  • ,TwinGene
  • ,i2b2
Part of PGC29 (PMID: 29700475)