Trait Information | |
Identifier | MONDO_0002009 |
Description | An episode of depression lasting two or more weeks without an intervening episode of mania. [NCIT: P378] | Trait category |
Neurological disorder
|
Synonyms |
2 synonyms
|
Mapped term(s) |
12 mapped terms
|
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000138 | LifetimeMDD | PGP000068 Cai N et al. Nat Genet (2020) | Lifetime Major Depressive Disorder | major depressive disorder | 22,274 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000138/ScoringFiles/PGS000138.txt.gz |
PGS000139 | MDDRecur | PGP000068 Cai N et al. Nat Genet (2020) | Lifetime Major Depressive Disorder (with recurrence) | major depressive disorder recurrent |
21,980 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000139/ScoringFiles/PGS000139.txt.gz |
PGS000145 | ICD10Dep | PGP000068 Cai N et al. Nat Genet (2020) | Depression (ICD-10 defined) | major depressive disorder | 21,510 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000145/ScoringFiles/PGS000145.txt.gz |
PGS000193 | MDD_0.001_Coleman_2020 | PGS000080 Coleman JRI et al. Mol Psychiatry (2020) | Major depression | major depressive disorder | 1,138 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000193/ScoringFiles/PGS000193.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM000430 | PGS000138 (LifetimeMDD) |
PSS000250 | PGP000068 Cai N et al. (2020) | Reported Trait: Major Depressive Disorder status | — | AUROC: 0.5611 | R²: 0.01817 | Cohort | — |
PPM000431 | PGS000139 (MDDRecur) |
PSS000250 | PGP000068 Cai N et al. (2020) | Reported Trait: Major Depressive Disorder status | — | AUROC: 0.54874 | R²: 0.01097 | Cohort | — |
PPM000437 | PGS000145 (ICD10Dep) |
PSS000250 | PGP000068 Cai N et al. (2020) | Reported Trait: Major Depressive Disorder status | — | AUROC: 0.5251 | R²: 0.0032 | Cohort | — |
PPM000564 | PGS000193 (MDD_0.001_Coleman_2020) |
PSS000294 | PGS000080 Coleman JRI et al. (2020) | Reported Trait: Major depressive disorder | OR: 1.179 | — | R²: 0.01485 Nagelkerke pseudo-R2 (increase when adding PRS to null model of covariates): 0.00785 |
batch, centre, genomic prinicipal components (x6) | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000250 | — | — | [
|
— | European | — | 15 cohorts
|
Part of PGC29 (PMID: 29700475) |
PSS000294 | Participants completed an online follow-up questionnaire assessing common mental health disorders, including MDD symptoms. Phenotypes were derived from this questionnaire. Individuals with probable MDD met lifetime criteria based on their responses to questions derived from the Composite International Diagnostic Interview. We excluded cases if they self-reported diagnoses of schizophrenia, other psychoses, or bipolar disorder. Controls were excluded if they self-reported any mental illness, taking any drug with an antidepressant indication, or had been hospitalised with a mood disorder or met previously-defined criteria for a mood disorder. | — | [ ,
45.0 % Male samples |
Range = [46.0, 80.0] years | European | — | UKB | — |