PGS Catalog - major depressive disorder (Polygenic Trait)

Trait: major depressive disorder

Trait Information
Identifier	MONDO_0002009
Description	An episode of depression lasting two or more weeks without an intervening episode of mania. [NCIT: P378]
Trait category	Neurological disorder
Synonyms	2 synonyms single major depressive episode recurrent major depression
Mapped term(s)	12 mapped terms ICD9:296.20 ICD10:F33 ICD10:F32.9 ICD10:F32 DOID:1470 MFOMD:0000143 ICD9:296.3 SCTID:370143000 ICD9:296.2 MESH:D003865 ICD10:F33.9 ICD9:296.30

Associated Polygenic Score(s)

Polygenic Score (PGS) ID	PGS Name	PGS Publication (PGP) ID	Reported Trait	Number of Variants	PGS Scoring File (FTP Link)
PGS000138	LifetimeMDD	PGP000068 Cai N et al. Nat Genet (2020)	Lifetime Major Depressive Disorder	22,274	http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000138/ScoringFiles/PGS000138.txt.gz
PGS000139	MDDRecur	PGP000068 Cai N et al. Nat Genet (2020)	Lifetime Major Depressive Disorder (with recurrence)	21,980	http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000139/ScoringFiles/PGS000139.txt.gz
PGS000145	ICD10Dep	PGP000068 Cai N et al. Nat Genet (2020)	Depression (ICD-10 defined)	21,510	http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000145/ScoringFiles/PGS000145.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM ID)	Evaluated Score	PGS Sample Set ID (PSS ID)	Performance Source	Trait	PGS Effect Sizes (per SD change)	PGS Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM000437	PGS000145 (ICD10Dep)	PSS000250	PGP000068 Cai N et al. (2020)	Reported Trait: Major Depressive Disorder status	—	AUROC: 0.5251015	R²: 0.003198656	Cohort	—
PPM000430	PGS000138 (LifetimeMDD)	PSS000250	PGP000068 Cai N et al. (2020)	Reported Trait: Major Depressive Disorder status	—	AUROC: 0.5611035	R²: 0.018171054	Cohort	—
PPM000431	PGS000139 (MDDRecur)	PSS000250	PGP000068 Cai N et al. (2020)	Reported Trait: Major Depressive Disorder status	—	AUROC: 0.5487412	R²: 0.01097163	Cohort	—

Evaluated Samples

PGS Sample Set ID (PSS ID)	Detailed Phenotype Description	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS000250	—	—	36,709 individuals [ 14,696 cases , 22,013 controls ]	—	European	—	15 cohorts BOMA ,CoLaus ,Edinburgh ,GenPOD ,GenRED ,MARS ,MPIP ,NESDA ,QIMR ,RADIANT ,RS ,SHIP ,STAR*D ,TwinGene ,i2b2	Part of PGC29 (PMID: 29700475)