Publications

PGS Publication/Study ID (PGP) PGS Developed PGS Evaluated First Author Title Journal Name Publication Date Digital object identifier (doi) PubMed ID (PMID)
PGP000101 1 1 Zhang Q Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture. Nat Commun 23/09/2020 10.1038/s41467-020-18534-1 32968074
PGP000701 10 11 Loesch DP Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities. Nat Commun 03/03/2025 10.1038/s41467-025-56695-z 40032831
PGP000112 4 4 Ho WK European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nat Commun 31/07/2020 10.1038/s41467-020-17680-w 32737321
PGP000708 0 1 Ding C Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease. Nat Commun 14/12/2023 10.1038/s41467-023-43064-x 38097541
PGP000721 0 6 Sadler MC Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications. Nat Commun 25/03/2025 10.1038/s41467-025-58152-3 40133288
PGP000723 26 26 Xiang R Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction. Nat Commun 07/05/2025 10.1038/s41467-025-59525-4 40335489
PGP000086 1 1 Shrine N New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet 25/02/2019 10.1038/s41588-018-0321-7 30804560
PGP000223 1 1 Lotta LA Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet 14/11/2016 10.1038/ng.3714 27841877
PGP000296 1 1 Pirruccello JP Deep learning enables genetic analysis of the human thoracic aorta. Nat Genet 26/11/2021 10.1038/s41588-021-00962-4 34837083
PGP000594 1 1 Ghouse J Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. Nat Genet 17/04/2024 10.1038/s41588-024-01720-y 38632349
PGP000513 2 2 Roychowdhury T Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nat Genet 16/10/2023 10.1038/s41588-023-01510-y 37845353
PGP000068 8 8 Cai N Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet 30/03/2020 10.1038/s41588-020-0594-5 32231276
PGP000061 1 1 MacGregor S Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma. Nat Genet 27/07/2018 10.1038/s41588-018-0176-y 30054594
PGP000098 1 1 Grove J Identification of common genetic risk variants for autism spectrum disorder. Nat Genet 25/02/2019 10.1038/s41588-019-0344-8 30804558
PGP000691 1 1 Lee DSM Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. Nat Genet 07/04/2025 10.1038/s41588-025-02140-2 40195560
PGP000122 1 1 Conti DV Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 04/01/2021 10.1038/s41588-020-00748-0 33398198
PGP000593 6 6 Ojima T Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses. Nat Genet 11/06/2024 10.1038/s41588-024-01782-y 38862855
PGP000146 1 1 Harper AR Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity. Nat Genet 25/01/2021 10.1038/s41588-020-00764-0 33495597
PGP000128 46 46 Sinnott-Armstrong N Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet 18/01/2021 10.1038/s41588-020-00757-z 33462484
PGP000392 1 1 Miyazawa K Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction. Nat Genet 19/01/2023 10.1038/s41588-022-01284-9 36653681
PGP000581 3 3 Keaton JM Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nat Genet 30/04/2024 10.1038/s41588-024-01714-w 38689001
PGP000491 1 0 Fernandez-Rozadilla C Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nat Genet 20/12/2022 10.1038/s41588-022-01222-9 36539618
PGP000260 1 1 Barc J Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat Genet 24/02/2022 10.1038/s41588-021-01007-6 35210625
PGP000309 1 1 Bellenguez C New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet 04/04/2022 10.1038/s41588-022-01024-z 35379992
PGP000302 2 2 Horowitz JE Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease. Nat Genet 03/03/2022 10.1038/s41588-021-01006-7 35241825
PGP000283 2 2 Evangelou E Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet 17/09/2018 10.1038/s41588-018-0205-x 30224653
PGP000489 82 82 Zhang H A new method for multiancestry polygenic prediction improves performance across diverse populations. Nat Genet 25/09/2023 10.1038/s41588-023-01501-z 37749244
PGP000182 1 2 Tadros R Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nat Genet 25/01/2021 10.1038/s41588-020-00762-2 33495596
PGP000332 415 415 Weissbrod O Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores. Nat Genet 07/04/2022 10.1038/s41588-022-01036-9 35393596
PGP000181 1 1 Liu G Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease. Nat Genet 06/05/2021 10.1038/s41588-021-00847-6 33958783
PGP000268 1 1 Tcheandjieu C High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease. Nat Genet 30/05/2022 10.1038/s41588-022-01070-7 35637384
PGP000246 3 3 Chen J The trans-ancestral genomic architecture of glycemic traits. Nat Genet 31/05/2021 10.1038/s41588-021-00852-9 34059833
PGP000390 1 1 Wuttke M A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet 31/05/2019 10.1038/s41588-019-0407-x 31152163
PGP000341 1 1 Vujkovic M A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nat Genet 02/06/2022 10.1038/s41588-022-01078-z 35654975
PGP000409 2 2 Aragam KG Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nat Genet 06/12/2022 10.1038/s41588-022-01233-6 36474045
PGP000672 6 6 Jurgens SJ Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. Nat Genet 21/11/2024 10.1038/s41588-024-01975-5 39572784
PGP000692 4 4 Hoffmann TJ Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups. Nat Genet 10/02/2025 10.1038/s41588-024-02068-z 39930085
PGP000195 1 0 Ferreira MA Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat Genet 30/10/2017 10.1038/ng.3985 29083406
PGP000464 132 132 Liu N Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes. Nat Genet 19/06/2023 10.1038/s41588-023-01425-8 37337106
PGP000500 4 4 Shrine N Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nat Genet 13/03/2023 10.1038/s41588-023-01314-0 36914875
PGP000694 3 6 Jia G Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction. Nat Genet 13/05/2024 10.1038/s41588-024-01736-4 38741014
PGP000211 33 34 Aly DM Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes Nat Genet 04/11/2021 10.1038/s41588-021-00948-2 34737425
PGP000104 1 1 Koyama S Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease. Nat Genet 05/10/2020 10.1038/s41588-020-0705-3 33020668
PGP000006 5 5 Khera AV Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet 13/08/2018 10.1038/s41588-018-0183-z 30104762
PGP000023 1 0 Mahajan A Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet 08/10/2018 10.1038/s41588-018-0241-6 30297969
PGP000019 1 1 Schumacher FR Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat Genet 11/06/2018 10.1038/s41588-018-0142-8 29892016
PGP000398 1 1 Ghouse J Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism. Nat Genet 19/01/2023 10.1038/s41588-022-01286-7 36658437
PGP000664 1 1 Park S Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome. Nat Genet 30/09/2024 10.1038/s41588-024-01933-1 39349817
PGP000642 2 2 Zheng SL Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings. Nat Genet 18/02/2025 10.1038/s41588-025-02094-5 39966645
PGP000088 5 7 Zhang H Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses. Nat Genet 18/05/2020 10.1038/s41588-020-0609-2 32424353
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