PGS Catalog - PGS Catalog Search

glaucoma

MONDO_0005041

Other trait

Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor. [NCIT: P378]

open-angle glaucoma

MONDO_0005338

Other trait

Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage. [NCIT: P378]

Associated PGS 5 Show Reported Traits

Glaucoma genetic risk scores in the Million Veteran Program.

Waksmunski AR et al. (2022) - OphthalmologyPMID:35718050doi:10.1016/j.ophtha.2022.06.012PGP000352

PGS developed 1 - PGS evaluated 1

Genetic Associations Between Smoking- and Glaucoma-Related Traits.

Tran JH et al. (2023) - Transl Vis Sci TechnolPMID:36786746doi:10.1167/tvst.12.2.20PGP000471

PGS developed 2 - PGS evaluated 2

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.

Craig JE et al. (2020) - Nat GenetPMID:31959993doi:10.1038/s41588-019-0556-yPGP000066

PGS developed 1 - PGS evaluated 1

A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIT: C26767]

Associated PGS 49 Show Reported Traits

disorder of orbital region

MONDO_0002022

Other trait

A disease that involves the orbital region. [MONDO: patterns/location]

Associated PGS 49 Show Reported Traits

disorder of visual system

MONDO_0024458

Other trait

A disease that involves the visual system. [MONDO: patterns/location]

Associated PGS 49 Show Reported Traits

PGS002761

Name: Glaucoma_prscsNumber of Variants: 1,082,518Publication ID: PGP000364

Reported trait: GlaucomaMapped trait(s): glaucoma MONDO_0005041

PGS000137

Name: MTAG_glaucomaNumber of Variants: 2,673Publication ID: PGP000066

Reported trait: GlaucomaMapped trait(s): glaucoma MONDO_0005041

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

MacGregor S et al. (2018) - Nat GenetPMID:30054594doi:10.1038/s41588-018-0176-yPGP000061

PGS developed 1 - PGS evaluated 1

Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.

Sekimitsu S et al. (2023) - JAMA OphthalmolPMID:37589995doi:10.1001/jamaophthalmol.2023.3645PGP000670

PGS developed 1 - PGS evaluated 1

Genetic risk of glaucoma is associated with vascular and retinal nerve fibre wedge defects.

Saks DG et al. (2023) - Acta OphthalmolPMID:37800621doi:10.1111/aos.15775PGP000688

PGS developed 0 - PGS evaluated 1

High Polygenic Risk Is Associated with Earlier Trabeculectomy in Patients with Primary Open-Angle Glaucoma.

Marshall HN et al. (2022) - Ophthalmol GlaucomaPMID:35842105doi:10.1016/j.ogla.2022.06.009PGP000588

PGS developed 0 - PGS evaluated 1

PGS004765

Name: glaucoma_PRSmix_eurNumber of Variants: 835,476Publication ID: PGP000604

Reported trait: GlaucomaMapped trait(s): glaucoma MONDO_0005041

Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.

Fan BJ et al. (2019) - JAMA OphthalmolPMID:31436842doi:10.1001/jamaophthalmol.2019.3109PGP000115

PGS developed 1 - PGS evaluated 1

The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.

Cole BS et al. (2021) - Invest Ophthalmol Vis SciPMID:33605984doi:10.1167/iovs.62.2.28PGP000169

PGS developed 1 - PGS evaluated 1

Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.

Gao XR et al. (2022) - Nat CommunPMID:36450729doi:10.1038/s41467-022-35188-3PGP000426

PGS developed 1 - PGS evaluated 1

PGS004766

Name: glaucoma_PRSmixPlus_eurNumber of Variants: 837,948Publication ID: PGP000604

Reported trait: GlaucomaMapped trait(s): glaucoma MONDO_0005041

Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging.

He W et al. (2022) - JAMA OphthalmolPMID:35446358doi:10.1001/jamaophthalmol.2022.0891PGP000321

PGS developed 1 - PGS evaluated 1

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma.

Siggs OM et al. (2022) - JAMA OphthalmolPMID:36355370doi:10.1001/jamaophthalmol.2022.4688PGP000403

PGS developed 0 - PGS evaluated 1

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.

Qassim A et al. (2020) - OphthalmologyPMID:32081492doi:10.1016/j.ophtha.2019.12.025PGP000225

PGS developed 1 - PGS evaluated 1

Systematic comparison of family history and polygenic risk across 24 common diseases.

Mars N et al. (2022) - Am J Hum GenetPMID:36347255doi:10.1016/j.ajhg.2022.10.009PGP000364

PGS developed 21 - PGS evaluated 21

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.

Wang Y et al. (2023) - Cell GenomPMID:36777179doi:10.1016/j.xgen.2022.100241PGP000262

PGS developed 18 - PGS evaluated 18

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases.

Truong B et al. (2024) - Cell GenomPMID:38508198doi:10.1016/j.xgen.2024.100523PGP000604

PGS developed 158 - PGS evaluated 158

disease by body system or component

MONDO_7770006

Other trait

A grouping class for human diseases classified by the body system or anatomical component primarily affected.

Associated PGS 2072 Show Reported Traits

Abdominal aortic aneurysm
Acute appendicitis
Acute appendicitis (time-to-event)
Acute lymphoblastic leukemia
Acute myocardial infarction (time-to-event)
Age asthma diagnosed
Age diabetes diagnosed
Age hayfever or allergic rhinitis diagnosed by doctor
Age-related macular degeneration
Alcohol-associated liver cirrhosis
Alcoholic cirrhosis
All-cause dementia
All-cause dementia (algorithmically-defined)
Allergic disease
Allergic disease (asthma, hay fever or eczema)
Allergic disease (hay fever or allergic rhinitis) (diagnosed by doctor)
Allergic disease (hay fever, allergic rhinitis, or eczema)
Allergic disease (hay fever, rhinitis or eczema)
Allergic disease (hay fever, rhinitis, or eczema) (diagnosed by doctor)
Allergy
Allergy/adverse effect of penicillin
Alzheimer's disease
Alzheimer's disease (algorithmically-defined)
Alzheimer's disease (late onset)
Alzheimer's disease (time-to-event)
Alzheimer's disease in non APOE
Anal and rectal polyp
Ankylosing spondylitis
Ankylosing spondylitis (time-to-event)
Aortic stenosis
Appendiceal conditions
Appendicitis
Arthritis (nos)
Asthma
Asthma (algorithmically-defined)
Asthma (diagnosed by doctor)
Asthma (time-to-event)
Atopic dermatitis
Atopic eczema
Atopic eczema or atopic disease
Atrial Fibrillation
Atrial fibrillation
Atrial fibrillation (PheCode 427.21)
Atrial fibrillation and flutter
Atrial fibrillation and flutter (time-to-event)
Atrial flutter
Attention deficit hyperactivity disorder
Attention-deficit hyperactivity disorder
Autism spectrum disorder
Autoimmune Addison's disease
Autoimmune disease
Benign neoplasm of colon
Benign neoplasm of other parts of digestive system
Benign neoplasm of uterus
Benign nodular goiter
Bipolar disorder
Bladder cancer
Blood clot (diagnosed by doctor)
Blood clot or deep vein thrombosis (diagnosed by doctor)
Brain and nervous system cancer
Brain cancer
Breast cancer
Breast cancer (female)
Breast cancer intrinsic-like subtype (HER2-enriched-like)
Breast cancer intrinsic-like subtype (luminal A-like)
Breast cancer intrinsic-like subtype (luminal B-like)
Breast cancer intrinsic-like subtype (luminal B/HER2-negative-like)
Breast cancer intrinsic-like subtype (triple negative)
Breast carcinoma
Broad Depression (seen a General Practitioner for nerves, anxiety, tension or depression)
Brugada syndrome
C34 (Malignant neoplasm of bronchus and lung)
CHARGE-AF predicted 5-year risk of atrial fibrillation
Calculus of kidney and ureter (time-to-event)
Cancer of other female genital organs
Cancer of other male genital organs
Carcinoma in situ of skin
Cardiomyopathy
Cardiovascular disease
Cataract
Celiac disease
Celiac disease or gluten sensitivity, diagnosed
Cerebrovascular disease
Cervical cancer
Childhood asthma
Childhood steroid-sensitive nephrotic syndrome
Childhood sunburn
Cholelithiasis
Cholelithiasis (time-to-event)
Cholelithiasis and cholecystitis
Chronic airway obstruction
Chronic ischaemic heart disease (time-to-event)
Chronic kidney disease
Chronic kidney disease (CKD)
Chronic kidney disease (stage 3 or greater)
Chronic kidney disease (stage 3 or higher)
Chronic lymphocytic leukemia
Chronic lymphoid leukemia
Chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (algorithmically-defined)
Chronic renal failure (time-to-event)
Circulatory disease NEC
Cirrhosis
Cirrhosis (alcohol related)
Coeliac disease
Colon cancer
Colon polyp
Colorectal cancer
Colorectal neoplasm
Congenital deficiency of other clotting factors (including factor VII)
Congestive heart failure (CHF), NOS (PheCode 428.1)
Congestive heart failure; nonhypertensive
Connective tissue disorder
Contracture of palmar fascia [Dupuytren's disease]
Corneal dystrophy
Coronary Artery Disease
Coronary artery diseae
Coronary artery disease
Coronary artery disease (CAD)
Coronary artery disease (Endothelial cell-related)
Coronary atherosclerosis
Coronary heart disease
Coronary vascular disease (CVD)
Corpus Uteri
Coxarthrosis [arthrosis of hip] (time-to-event)
Crohn's disease
Crohn's disease [regional enteritis] (time-to-event)
Cutaneous melanoma
D12 (Benign neoplasm of colon, rectum, anus and anal canal)
Dementia
Dementia in Alzheimer's disease (time-to-event)
Depression
Depression (ICD-10 defined)
Dermatologic diseases
Diabetes
Diabetes (any type)
Diabetic Retinopathy
Diabetic eye disease
Diabetic retinopathy
Diagnosed with coeliac disease or gluten sensitivity
Diffuse large B-cell lymphoma
Dilated cardiomyopathy
Dilated cardiomyopathy (MTAG)
Diseases of hair and hair follicles
Diverticular disease
Diverticular disease of intestine (time-to-event)
Diverticular disease/diverticulitis
Duodenal ulcer (time-to-event)
Duodenitis
Dupuytren's contracture
E03 (Other hypothyroidism)
ECG-AI predicted 5-year risk of atrial fibrillation
ER-negative breast cancer
ER-positive breast cancer
Early onset colorectal cancer
Eczema, dermatitis
Emphysema
Endocrine and diabetes diseases
Endometrial cancer
Endometriosis
Enlarged prostate
Enthesitis-related Juvenile Idiophatic Arthritis
Eosinophilic esophagitis (EOE)
Epilepsy
Epithelial ovarian cancer
Esophageal adenocarcinoma
Esophageal adenocarcinoma or Barrett’s esophagus
Esophageal cancer
Esophagitis, GERD and related diseases
Essential (primary hypertension) (time-to-event)
Essential hypertension
Estrogen receptor [ER]-negative breast cancer
Estrogen receptor [ER]-positive breast cancer
Estrogen receptor negative breast cancer
Estrogen receptor positive breast cancer
Estrogen-receptor negative breast cancer
Estrogen-receptor positive breast cancer
Eye problems/disorders (Glaucoma)
F10 (Mental and behavioural disorders due to use of alcohol)
F17 (Mental and behavioural disorders due to use of tobacco)
F41 (Other anxiety disorders)
Fibroblastic disorders (time-to-event)
Follicular cysts of skin and subcutaneous tissue (time-to-event)
Follicular lymphoma
Functional digestive disorders
G56 (Mononeuropathies of upper limb)
Gallstones
Ganglion and cyst of synovium, tendon, and bursa
Gastric cancer
Gastrointestinal cancer
General atopic disease
General atopic disease (IL-12 related variants)
General atopic disease (IL-17 related variants)
General atopic disease (IL-4 related variants)
Genital prolapse
Gestational diabetes mellitus in early pregnancy
Gestational hypertension
Glaucoma
Glaucoma (time-to-event)
Glioblastoma
Glioma
Gonarthrosis [arthrosis of knee] (time-to-event)
Graves' disease
H26 (Other cataract)
Hayfever/allergic rhinitis
Headaches for 3+ months
Hearing aid use
Hearing difficulty
Hearing difficulty and deafness
Hearing difficulty/problems
Heart failure
Hematologic disease, genetic
Hemorrhoid
Hemorrhoids
High grade serous ovarian cancer
Hip osteoarthritis
Hodgkin lymphoma
Hodgkin's disease
Hyperplasia of prostate
Hyperplasia of prostate (time-to-event)
Hypertension
Hyperthyroidism, thyrotoxicosis
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (MTAG)
Hypothyroidism
Hypothyroidism (self-reported)
Hypothyroidism/myxoedema
I10 (Essential (primary) hypertension)
I21 (Acute myocardial infarction)
I25 (Chronic ischemic heart disease)
I26 (Pulmonary embolism)
I48 (Atrial fibrillation and flutter)
I50 (Heart failure)
I84 (Hemorrhoids)
Idiopathic pulmonary fibrosis
IgA nephropathy
Incident atrial fibrillation
Incident coronary artery disease
Incident hypertension
Incident type 2 diabetes
Inflammation of the eye
Inflammatory bowel disease
Inflammatory bowel disease (IBD)
Insomnia
Insulin-dependent diabetes mellitus (time-to-event)
Intracerebral hemorrhage
Intracranial aneurysm
Invasive epithelial ovarian cancer
Iritis
Ischemic stroke
J33 (Nasal polyp)
J44 (Other chronic obstructive pulmonary disease)
J45 (Asthma)
Juvenile Idiopathic Arthritis
K21 (Gastroesophageal reflux disease)
K22 (Other diseases of oesophagus)
K29 (Gastritis and duodenitis)
K57 (Diverticular disease of intestine)
K59 (Other functional intestinal disorders)
K80 (Cholelithiasis)
Keratinocyte cancer
Keratoconus
Kidney cancer
Kidney failure
Knee osteoarthritis
Laryngeal cancer
Late-onset Alzheimer's disease
Late-onset Alzheimers disease (based on SNPs in genes involved in synaptic function)
Late-onset Alzheimer’s disease
Lifetime Major Depressive Disorder
Lifetime Major Depressive Disorder (with recurrence)
Lung adenocarcinoma
Lung and bronchus cancer
Lung cancer
Lung cancer in never smokers
Lung squamous cell carcinoma
Lupus (localized and systemic)
Lymphocytic leukemia
Lymphocytic thyroiditis
Lymphoid leukemia
M13 (Other arthritis)
M16 (Coxarthrosis [arthrosis of hip])
M17 (Gonarthrosis [arthrosis of knee])
M19 (Other arthrosis)
M25 (Other joint disorders, not elsewhere classified)
M47 (Spondylosis)
M48 (Other spondylopathies)
M51 (Other intervertebral disk disorders)
M81 (Osteoporosis without pathological fracture)
Macular degeneration
Macular degeneration (senile) of retina NOS
Major Depressive Disorder
Major Depressive Disorder (Lifetime)
Major depression
Major depressive disorder
Malabsorption/coeliac disease
Male genital tract cancer
Malignant neoplasm of kidney, except pelvis
Malignant neoplasm of ovary
Malignant neoplasm of rectum, rectosigmoid junction, and anus
Malignant neoplasm of testis
Malignant neoplasm of uterus
Marginal zone lymphoma
Mean pressure gradient
Melanoma
Migraine
Migraine (time-to-event)
Mitral valve prolapse
Moderate-to-severe atopic dermatitis
Multiple myeloma
Multiple sclerosis
Multiple sclerosis (time-to-event)
Myocardial infarction
Myocardial infarction (PheCode 411.2)
Myocardial infarction (algorithmically-defined)
N17 (Acute renal failure)
N18 (Chronic renal failure)
N20 (Calculus of kidney and ureter)
N39 (Other disorders of urinary system)
NSTEMI (algorithmically-defined)
Narcolepsy
Nasopharyngeal carcinoma
Neuroblastoma
Nodular lymphoma
Non melanoma skin cancer
Non-Hodgkin's lymphoma
Non-alcoholic fatty liver disease
Non-insulin-dependent diabetes (time-to-event)
Non-mucinous epithelial ovarian cancer
Nonalcoholic fatty liver disease
Nonmucinous Epithelial Ovarian Cancer
Nonrheumatic aortic valve disorders (time-to-event)
Nontoxic multinodular goiter
Obstructive sleep apnea
Obstructive sleep apnea (AdjustedBMI)
Obstructive sleep apnea (BMI adjusted)
Obstructive sleep apnea (UnadjustedBMI)
Occlusion and stenosis of precerebral arteries
Ocular cancer
Oligoarthritis Juvenile Idiophatic Arthritis
Oral cavity and pharyngeal cancers
Oral cavity cancer
Osteoarthritis
Osteoarthrosis
Osteoporosis
Osteoporosis without pathological fracture (time-to-event)
Other biliary tract disease
Other cataract (time-to-event)
Other chronic nonalcoholic liver disease
Other chronic obstructive pulmonary disease (time-to-event)
Other coagulation defects (time-to-event)
Other dermatitis (time-to-event)
Other diseases of intestine (time-to-event)
Other diseases of liver (time-to-event)
Other disorders of cornea (time-to-event)
Other disorders of pancreatic internal secretion (time-to-event)
Other hypothyroidism (time-to-event)
Other interstitial pulmonary diseases (time-to-event)
Other intervertebral disk disorders (time-to-event)
Other non-epithelial skin cancer
Other non-toxic goitre (time-to-event)
Other peripheral nerve disorders
Other retinal disorders (time-to-event)
Other rheumatoid arthritis (time-to-event)
Other systemic involvement of connective tissue (time-to-event)
Otosclerosis
Otosclerosis (time-to-event)
Ovarian cancer
Ovarian serous carcinoma
PE (time-to-event)
PE +/- DVT
Pancreatic cancer
Pancreatic ductal adenocarcinoma
Parkinson's disease
Parkinson's disease dementia
Peak aortic velocity
Pediatric steroid-sensitive nephrotic syndrome
Pelvic organ prolapse
Peptic ulcer disease
Peripheral arterial disease
Peripheral artery disease
Peripheral vascular disease, unspecified
Phlebitis and thrombophlebitis
Phlebitis and thrombophlebitis (time-to-event)
Polycythemia vera
Polymyalgia rheumatica
Post-traumatic stress disorder
Pre-eclampsia
Preeclampsia
Primary open-angle glaucoma
Primary-open angle glaucoma
Probable Depression (low mood or anhedonia, and seen a GP or psychiatrist for nerves, anxiety, tension or depression)
Prostate adenocarcinoma
Prostate cancer
Prostate carcinoma
Prurigo nodularis
Psoriasis
Psoriasis (time-to-event)
Psoriatic arthritis
Psoriatic arthropathy
Pulmonary embolism
Pulmonary fibrosis
Pulmonary heart disease
Reactive arthropathies (time-to-event)
Renal cancer
Respiratory and ear-nose-throat diseases
Respiratory system cancer
Retinal detachment
Retinal detachments and breaks (time-to-event)
Retinal detachments and defects
Retinal disorders in diseases classified elsewhere (time-to-event)
Rhesus isoimmunization in pregnancy
Rheumatoid Arthritis
Rheumatoid arthritis
Rheumatoid arthritis (CCP-negative)
Rheumatoid-factor-negative Polyarthritis (Juvenile Idiophatic Arthritis)
Sarcoidosis
Sarcoidosis (time-to-event)
Schizophrenia
Sebaceous cyst
Seborrheic keratosis
Seborrheic keratosis (time-to-event)
Seen a psychiatrist for nerves, anxiety, tension or depression
Seropositive rheumatoid arthritis
Seropositive rheumatoid arthritis (time-to-event)
Serous epithelial ovarian cancer
Sjogren's syndrome/sicca syndrome
Skin Melanoma
Skin cancer
Skin cutaneous melanoma
Sleep apnea
Sleeplessness / insomnia
Slipped disc
Spondyloarthroparthy
Spontaneous coronary artery dissection
Stomach cancer
Stroke
Superficial cellulitis and abscess
Systemic lupus erythematosus
Systemic sclerosis
T2D (cases vs HbA1c filtered controls)
Testicular cancer
Thyroid (self-reported conditions)
Thyroid cancer
Thyroid carcenoma
Thyroid carcenoma vs benign nodular goiter
Thyrotoxicosis [hyperthyroidism] (time-to-event)
Thyrotoxicosis with or without goiter
Tongue cancer
Total hip replacement
Total knee replacement
Triple negative breast cancer
Triple negative breast cancer versus luminal breast cancer
Triple-negative breast cancer
Type 1 bipolar disorder
Type 1 diabetes
Type 1 diabetes (T1D)
Type 2 Diabetes Mellitus
Type 2 bipolar disorder
Type 2 diabetes
Type 2 diabetes (T2D)
Type 2 diabetes (T2D) (PheCode 250.2)
Type 2 diabetes (based on SNPs associated with adiposity)
Type 2 diabetes (based on SNPs associated with beta cell function)
Type 2 diabetes (based on SNPs associated with impaired lipids)
Type 2 diabetes (based on SNPs associated with insulin action)
Type 2 diabetes (based on SNPs associated with insulin action/secretion)
Type 2 diabetes (based on SNPs associated with insulin secretion)
Type 2 diabetes (based on SNPs associated with lipodystrophy)
Type 2 diabetes (based on SNPs associated with liver lipids)
Type 2 diabetes (based on SNPs associated with obesity)
Type 2 diabetes (based on SNPs associated with proinsulin levels)
Type 2 diabetes (based on SNPs involved in insulin resistance)
Type 2 diabetes (based on SNPs involved in β-cell function)
Type 2 diabetes mellitus
Ulcerative colitis
Ulcerative colitis (time-to-event)
Unspecified acute lower respiratory infection (time-to-event)
Unspecified dementia (time-to-event)
Unspecified diabetes mellitus (time-to-event)
Upper gastrointestinal cancer
Urinary calculus
Uterine cancer
Uterine endometrial carcinoma
Uterine fibroids
Vascular dementia (time-to-event)
Vascular/heart problems diagnosed by doctor Heart attack
Vascular/heart problems diagnosed by doctor High BP
Vasomotor and allergic rhinitis (time-to-event)
Venous thromboembolism
Venous thromboembolism (VTE)
Viral warts (time-to-event)
Vitamin B12 deficiency induced anemia (time-to-event)
Vitiligo
Vitiligo (time-to-event)
Waldenström macroglobulinemia
Zoster [herpes zoster] (time-to-event)
previously: Blood clot in the leg (DVT) or lung
previously: Blood clot in the lung

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

Privé F et al. (2022) - Am J Hum GenetPMID:34995502doi:10.1016/j.ajhg.2021.11.008PGP000263

PGS developed 430 - PGS evaluated 430

Significant sparse polygenic risk scores across 813 traits in UK Biobank.

Tanigawa Y et al. (2022) - PLoS GenetPMID:35324888doi:10.1371/journal.pgen.1010105PGP000244

PGS developed 779 - PGS evaluated 814

Search results for "glaucoma"

glaucoma

open-angle glaucoma

Glaucoma genetic risk scores in the Million Veteran Program.

Genetic Associations Between Smoking- and Glaucoma-Related Traits.

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.

eye disorder

disorder of orbital region

disorder of visual system

PGS002761

PGS000137

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.

Genetic risk of glaucoma is associated with vascular and retinal nerve fibre wedge defects.

High Polygenic Risk Is Associated with Earlier Trabeculectomy in Patients with Primary Open-Angle Glaucoma.

PGS004765

Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.

The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.

Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.

PGS004766

Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging.

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma.

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.

Systematic comparison of family history and polygenic risk across 24 common diseases.

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases.

disease by body system or component

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

Significant sparse polygenic risk scores across 813 traits in UK Biobank.