| Publication Information (EuropePMC) | |
| Title | Genetic Associations of Chronotype in the Finnish General Population. |
| PubMed ID | 32579418(Europe PMC) |
| doi | 10.1177/0748730420935328 |
| Publication Date | June 24, 2020 |
| Journal | J Biol Rhythms |
| Author(s) | Maukonen M, Havulinna AS, Männistö S, Kanerva N, Salomaa V, Partonen T. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000336 (GRS313_Chron) |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Chronotype | chronotype measurement | 313 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000336/ScoringFiles/PGS000336.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000905 | PGS000336 (GRS313_Chron) |
PSS000452| European Ancestry| 7,436 individuals |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Reported Trait: Later (evening) chronotype | OR: 1.24 [1.18, 1.31] | — | R²: 0.01312 | Age, sex, PCs (1-5), genotyping batch | — |
| PPM000904 | PGS000336 (GRS313_Chron) |
PSS000453| European Ancestry| 7,436 individuals |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Reported Trait: Later (evening) chronotype | β: -0.49 (0.05) | — | R²: 0.01378 | Age, sex, PCs (1-5), genotyping batch | — |
| PPM000906 | PGS000336 (GRS313_Chron) |
PSS000451| European Ancestry| 8,433 individuals |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Reported Trait: Later (evening) chronotype | OR: 1.3 [1.24, 1.37] | — | R²: 0.01893 | Age, sex, PCs (1-5), genotyping batch | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000451 | Chronotype was assessed using a singl self-evaluatation question from a shortend version of Horne and Ostber'gs MEQ (sMEQ) on chronotype. The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. For the single self-evaluation question item 19 was used. The question was used as a binary varable in which those who replied either "rather more an evening than a morning type" or "definitely an evening type" were regarded as evening types, and those who replied "definitely a morning type" or "rather more a morning type than an evening type" were regarrded as morning types. | — | [ ,
47.78 % Male samples |
— | European (Finnish) |
— | FINRISK | Included participants from the National FINRISK 2007 and 2012 studies |
| PSS000452 | Chronotype was assessed using a shortend version of Horne and Ostberg's MEQ(sMEQ) . The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. The sum score was used as a binary variable (evening type: socres from 5-15, morning type: socres from 16 to 27; binary sMEQ score). | — | [ ,
46.4 % Male samples |
— | European (Finnish) |
— | FINRISK | Included participants from the National FINRISK 2007 and 2012 studies |
| PSS000453 | Chronotype was assessed using a shortend version of Horne and Ostberg's MEQ(sMEQ) The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. The sum score was used as a continuous variable (continuous sMEQ score). | — | 7,436 individuals | — | European (Finnish) |
— | FINRISK | Included participants from the National FINRISK 2007 and 2012 studies |