PGS Publication: PGP000183

Publication Information (EuropePMC)
Title Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.
PubMed ID 32775599(Europe PMC)
doi 10.1002/dad2.12074
Publication Date Aug. 5, 2020
Journal Alzheimers Dement (Amst)
Author(s) Zhou X, Chen Y, Ip FCF, Lai NCH, Li YYT, Jiang Y, Zhong H, Chen Y, Zhang Y, Ma S, Lo RMN, Cheung K, Tong EPS, Ko H, Shoai M, Mok KY, Hardy J, Mok VCT, Kwok TCY, Fu AKY, Ip NY.
Released in PGS Catalog: May 28, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000779
(PGS7_AD)
PGP000183 |
Zhou X et al. Alzheimers Dement (Amst) (2020)
Alzheimer's disease Alzheimer's disease 7
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000779/ScoringFiles/PGS000779.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002022 PGS000779
(PGS7_AD)
PSS001005|
East Asian Ancestry|
112 individuals
PGP000183 |
Zhou X et al. Alzheimers Dement (Amst) (2020)
Reported Trait: Alzheimer's disease AUROC: 0.612 Beta (β, top 33.3% vs bottom 33.3%): 1.485 (0.602) Age, sex
PPM002023 PGS000779
(PGS7_AD)
PSS001006|
European Ancestry|
2,696 individuals
PGP000183 |
Zhou X et al. Alzheimers Dement (Amst) (2020)
Reported Trait: Alzheimer's disease AUROC: 0.717 Beta (β, top 33.3% vs bottom 33.3%): 2.283 (1.021) Age, sex, PCs(1-5)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001005 Cases include individuals with Alzheimer's disease (AD) The phenotypes of the participants were determined on the basis of the most recent diagnostic records (until December 2019).
[
  • 33 cases
  • , 79 controls
]
,
54.29 % Male samples
East Asian
(Chinese)
Participants recruited from the Specialist Outpatient Department of Prince of Wales Hospital.
PSS001006 Cases include individuals with Alzheimer's disease (AD). Patients with definite AD have been diagnosed according to established neuropathological criteria (CERAD, Braak, Khachaturian, NIA-RI, or other established criteria).
[
  • 464 cases
  • , 2,232 controls
]
,
37.62 % Male samples
European LOAD