PGS Publication: PGP000210

Publication Information (EuropePMC)
Title Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program.
PubMed ID 31048771(Europe PMC)
doi 10.1038/s41598-019-43058-0
Publication Date May 2, 2019
Journal Sci Rep
Author(s) Zubair N, Conomos MP, Hood L, Omenn GS, Price ND, Spring BJ, Magis AT, Lovejoy JC.
Released in PGS Catalog: July 29, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000826
(Triglycerides_PGS)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Triglycerides triglyceride measurement 769
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000826/ScoringFiles/PGS000826.txt.gz - Check Terms/Licenses
PGS000824
(LDL-C_PGS)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Low-density lipoprotein cholesterol low density lipoprotein cholesterol measurement 809
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000824/ScoringFiles/PGS000824.txt.gz - Check Terms/Licenses
PGS000828
(WaistCircumference_PGS_F)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Waist circumference (female) waist circumference,
female
149
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000828/ScoringFiles/PGS000828.txt.gz - Check Terms/Licenses
PGS000829
(BMI_PGS_M)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Body mass index (male) body mass index,
male
290
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000829/ScoringFiles/PGS000829.txt.gz - Check Terms/Licenses
PGS000827
(WaistCircumference_PGS_M)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Waist circumference (male) waist circumference,
male
113
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000827/ScoringFiles/PGS000827.txt.gz - Check Terms/Licenses
PGS000830
(BMI_PGS_F)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Body mass index (female) body mass index,
female
372
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000830/ScoringFiles/PGS000830.txt.gz - Check Terms/Licenses
PGS000825
(HDL-C_PGS)
PGP000210 |
Zubair N et al. Sci Rep (2019)
High-density lipoprotein cholesterol high density lipoprotein cholesterol measurement 883
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000825/ScoringFiles/PGS000825.txt.gz - Check Terms/Licenses
PGS000831
(Total_cholesterol_PGS)
PGP000210 |
Zubair N et al. Sci Rep (2019)
Total cholesterol total cholesterol measurement 1,032
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000831/ScoringFiles/PGS000831.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002233 PGS000828
(WaistCircumference_PGS_F)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Waist circumference (female) : 0.032 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002234 PGS000827
(WaistCircumference_PGS_M)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Waist circumference (male) : 0.018 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002231 PGS000825
(HDL-C_PGS)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: High density lipoprotein cholesterol : 0.069 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002235 PGS000830
(BMI_PGS_F)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Body mass index (female) : 0.027 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002236 PGS000829
(BMI_PGS_M)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Body mass index (male) : 0.017 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002237 PGS000831
(Total_cholesterol_PGS)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Total cholesterol : 0.087 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002230 PGS000824
(LDL-C_PGS)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Low density lipoprotein cholesterol : 0.111 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor
PPM002232 PGS000826
(Triglycerides_PGS)
PSS001083|
Multi-ancestry (including European)|
2,531 individuals
PGP000210 |
Zubair N et al. Sci Rep (2019)
Reported Trait: Triglycerides : 0.039 Age at baseline, sex, enrollment channel, PCs(1-7), observation season, observation vendor

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001083 Of the 2,531 participants, 1,809 had longitudinal observations for total cholesterol (mg/dL), high density lipoprotein cholesterol (mg/dL) and trigycerides (mg/dL), 1,801 had longitudinal observations for low density lipoprotein cholesterol (mg/dL), 1,325 had longitudinal observations for waist circumference (inches), 2,355 had longitudinal observations for body mass index (kg/m^2) and 1,572 had longitudinal observations for homocysteine (μmol/L). 2,531 individuals,
40.0 % Male samples
Mean = 48.0 years
Sd = 12.0 years
European, Asian unspecified, Hispanic or Latin American, African unspecified, NR European = 1,999, Asian unspecified = 228, Hispanic or Latin American = 101, African unspecified = 51, Not reported = 152 Participants were obtained from the Scientific Wellness Program.