PGS Publication: PGP000212

Publication Information (EuropePMC)
Title Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.
PubMed ID 29280273(Europe PMC)
doi 10.1111/joim.12719
Publication Date Dec. 27, 2017
Journal J Intern Med
Author(s) Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J, Valenti L.
Released in PGS Catalog: Aug. 26, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000865
(PRS-HFC)
PGP000212 |
Dongiovanni P et al. J Intern Med (2017)
Hepatic fat content liver fat measurement 4
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000865/ScoringFiles/PGS000865.txt.gz
PGS000866
(PRS-HFC_SOS)
PGP000212 |
Dongiovanni P et al. J Intern Med (2017)
Hepatic fat content liver fat measurement 4
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000866/ScoringFiles/PGS000866.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002408 PGS000865
(PRS-HFC)
PSS001089|
Multi-ancestry (including European)|
4,570 individuals
PGP000212 |
Dongiovanni P et al. J Intern Med (2017)
Reported Trait: Steatosis : 0.035 Only 4,455 of the 4,570 individuals from DaHS were utilised as they had available genotype, phenotype and covariate data.
PPM002409 PGS000865
(PRS-HFC)
PSS001089|
Multi-ancestry (including European)|
4,570 individuals
PGP000212 |
Dongiovanni P et al. J Intern Med (2017)
Reported Trait: Alanine aminotransferase levels Association p-value (<): 0.001 Age, sex, ethnicity, body mass index, statin use Only 4,455 of the 4,570 individuals from DaHS were utilised as they had available genotype, phenotype and covariate data.
PPM002410 PGS000866
(PRS-HFC_SOS)
PSS001090|
European Ancestry|
3,329 individuals
PGP000212 |
Dongiovanni P et al. J Intern Med (2017)
Reported Trait: Alanine aminotransferase levels Association p-value (<): 1.00e-14 Age, sex, ethnicity, body mass index, statin use

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001089 Plasma levels of lipids and lipoproteins were measured by standard enzymatic assays. Hypertension was defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg, or self‐reported antihypertensive treatment. Of the 4,570 individuals, 1,496 had hypertension. 4,570 individuals,
43.0 % Male samples
Mean = 45.0 years
Sd = 11.0 years
European, African American or Afro-Caribbean, Hispanic or Latin American, Not reported European = 1,351, African American or Afro-Caribbean = 2,355, Hispanic or Latin American = 743, Not reported = 121 DaHS 40.12% sample overlap with this dataset and the dataset used to develop PRS-HFC.
PSS001090 All individuals were identified as being severly obese. Homeostasis model assessment-insulin resistance index was calculated from fasting levels of glucose and insulin. Plasma levels of lipids and lipoproteins were measured by standard enzymatic assays. 3,329 individuals,
30.0 % Male samples
Mean = 48.0 years
Sd = 6.0 years
European SOS