PGS Publication: PGP000230

Publication Information (EuropePMC)
Title The power of genetic diversity in genome-wide association studies of lipids.
PubMed ID 34887591(Europe PMC)
doi https://doi.org/10.1038/s41586-021-04064-3
Publication Date Dec. 9, 2021
Journal Nature
Author(s) Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Thuesen BH, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, Lamina C, Forer L, Scholz M, Galesloot TE, Bradfield JP, Daw EW, Zmuda JM, Mitchell JS, Fuchsberger C, Christensen H, Brody JA, Feitosa MF, Wojczynski MK, Preuss M, Mangino M, Christofidou P, Verweij N, Benjamins JW, Engmann J, Kember RL, Slieker RC, Lo KS, Zilhao NR, Le P, Kleber ME, Delgado GE, Huo S, Ikeda DD, Iha H, Yang J, Liu J, Leonard HL, Marten J, Schmidt B, Arendt M, Smyth LJ, Cañadas-Garre M, Wang C, Nakatochi M, Wong A, Hutri-Kähönen N, Sim X, Xia R, Huerta-Chagoya A, Fernandez-Lopez JC, Lyssenko V, Ahmed M, Jackson AU, Irvin MR, Oldmeadow C, Kim HN, Ryu S, Timmers PRHJ, Arbeeva L, Dorajoo R, Lange LA, Chai X, Prasad G, Lorés-Motta L, Pauper M, Long J, Li X, Theusch E, Takeuchi F, Spracklen CN, Loukola A, Bollepalli S, Warner SC, Wang YX, Wei WB, Nutile T, Ruggiero D, Sung YJ, Hung YJ, Chen S, Liu F, Yang J, Kentistou KA, Gorski M, Brumat M, Meidtner K, Bielak LF, Smith JA, Hebbar P, Farmaki AE, Hofer E, Lin M, Xue C, Zhang J, Concas MP, Vaccargiu S, van der Most PJ, Pitkänen N, Cade BE, Lee J, van der Laan SW, Chitrala KN, Weiss S, Zimmermann ME, Lee JY, Choi HS, Nethander M, Freitag-Wolf S, Southam L, Rayner NW, Wang CA, Lin SY, Wang JS, Couture C, Lyytikäinen LP, Nikus K, Cuellar-Partida G, Vestergaard H, Hildalgo B, Giannakopoulou O, Cai Q, Obura MO, van Setten J, Li X, Schwander K, Terzikhan N, Shin JH, Jackson RD, Reiner AP, Martin LW, Chen Z, Li L, Highland HM, Young KL, Kawaguchi T, Thiery J, Bis JC, Nadkarni GN, Launer LJ, Li H, Nalls MA, Raitakari OT, Ichihara S, Wild SH, Nelson CP, Campbell H, Jäger S, Nabika T, Al-Mulla F, Niinikoski H, Braund PS, Kolcic I, Kovacs P, Giardoglou T, Katsuya T, Bhatti KF, de Kleijn D, de Borst GJ, Kim EK, Adams HHH, Ikram MA, Zhu X, Asselbergs FW, Kraaijeveld AO, Beulens JWJ, Shu XO, Rallidis LS, Pedersen O, Hansen T, Mitchell P, Hewitt AW, Kähönen M, Pérusse L, Bouchard C, Tönjes A, Chen YI, Pennell CE, Mori TA, Lieb W, Franke A, Ohlsson C, Mellström D, Cho YS, Lee H, Yuan JM, Koh WP, Rhee SY, Woo JT, Heid IM, Stark KJ, Völzke H, Homuth G, Evans MK, Zonderman AB, Polasek O, Pasterkamp G, Hoefer IE, Redline S, Pahkala K, Oldehinkel AJ, Snieder H, Biino G, Schmidt R, Schmidt H, Chen YE, Bandinelli S, Dedoussis G, Thanaraj TA, Kardia SLR, Kato N, Schulze MB, Girotto G, Jung B, Böger CA, Joshi PK, Bennett DA, De Jager PL, Lu X, Mamakou V, Brown M, Caulfield MJ, Munroe PB, Guo X, Ciullo M, Jonas JB, Samani NJ, Kaprio J, Pajukanta P, Adair LS, Bechayda SA, de Silva HJ, Wickremasinghe AR, Krauss RM, Wu JY, Zheng W, den Hollander AI, Bharadwaj D, Correa A, Wilson JG, Lind L, Heng CK, Nelson AE, Golightly YM, Wilson JF, Penninx B, Kim HL, Attia J, Scott RJ, Rao DC, Arnett DK, Walker M, Koistinen HA, Chandak GR, Yajnik CS, Mercader JM, Tusié-Luna T, Aguilar-Salinas CA, Villalpando CG, Orozco L, Fornage M, Tai ES, van Dam RM, Lehtimäki T, Chaturvedi N, Yokota M, Liu J, Reilly DF, McKnight AJ, Kee F, Jöckel KH, McCarthy MI, Palmer CNA, Vitart V, Hayward C, Simonsick E, van Duijn CM, Lu F, Qu J, Hishigaki H, Lin X, März W, Parra EJ, Cruz M, Gudnason V, Tardif JC, Lettre G, 't Hart LM, Elders PJM, Damrauer SM, Kumari M, Kivimaki M, van der Harst P, Spector TD, Loos RJF, Province MA, Psaty BM, Brandslund I, Pramstaller PP, Christensen K, Ripatti S, Widén E, Hakonarson H, Grant SFA, Kiemeney LALM, de Graaf J, Loeffler M, Kronenberg F, Gu D, Erdmann J, Schunkert H, Franks PW, Linneberg A, Jukema JW, Khera AV, Männikkö M, Jarvelin MR, Kutalik Z, Cucca F, Mook-Kanamori DO, van Dijk KW, Watkins H, Strachan DP, Grarup N, Sever P, Poulter N, Rotter JI, Dantoft TM, Karpe F, Neville MJ, Timpson NJ, Cheng CY, Wong TY, Khor CC, Sabanayagam C, Peters A, Gieger C, Hattersley AT, Pedersen NL, Magnusson PKE, Boomsma DI, de Geus EJC, Cupples LA, van Meurs JBJ, Ghanbari M, Gordon-Larsen P, Huang W, Kim YJ, Tabara Y, Wareham NJ, Langenberg C, Zeggini E, Kuusisto J, Laakso M, Ingelsson E, Abecasis G, Chambers JC, Kooner JS, de Vries PS, Morrison AC, North KE, Daviglus M, Kraft P, Martin NG, Whitfield JB, Abbas S, Saleheen D, Walters RG, Holmes MV, Black C, Smith BH, Justice AE, Baras A, Buring JE, Ridker PM, Chasman DI, Kooperberg C, Wei WQ, Jarvik GP, Namjou B, Hayes MG, Ritchie MD, Jousilahti P, Salomaa V, Hveem K, Åsvold BO, Kubo M, Kamatani Y, Okada Y, Murakami Y, Thorsteinsdottir U, Stefansson K, Ho YL, Lynch JA, Rader DJ, Tsao PS, Chang KM, Cho K, O'Donnell CJ, Gaziano JM, Wilson P, Rotimi CN, Hazelhurst S, Ramsay M, Trembath RC, van Heel DA, Tamiya G, Yamamoto M, Kim BJ, Mohlke KL, Frayling TM, Hirschhorn JN, Kathiresan S, VA Million Veteran Program, Global Lipids Genetics Consortium, Boehnke M, Natarajan P, Peloso GM, Brown CD, Morris AP, Assimes TL, Deloukas P, Sun YV, Willer CJ
Released in PGS Catalog: Dec. 10, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 1,029,158
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000890/ScoringFiles/PGS000890.txt.gz
PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 1,119,211
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000892/ScoringFiles/PGS000892.txt.gz
PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 5,427
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000893/ScoringFiles/PGS000893.txt.gz
PGS000896
(GLGC_2021_SAS_LDL_PRS_weights_PRS-CS)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 1,100,062
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000896/ScoringFiles/PGS000896.txt.gz
PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 13
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000897/ScoringFiles/PGS000897.txt.gz
PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 66
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000891/ScoringFiles/PGS000891.txt.gz
PGS000894
(GLGC_2021_HIS_LDL_PRS_weights_PRS-CS)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 1,175,595
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000894/ScoringFiles/PGS000894.txt.gz
PGS000895
(GLGC_2021_HIS_LDL_PRS_weights_PT)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 76
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000895/ScoringFiles/PGS000895.txt.gz
PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 295
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000887/ScoringFiles/PGS000887.txt.gz
PGS000886
(GLGC_2021_AFR_LDL_PRS_weights_PRS-CS)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 1,222,318
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000886/ScoringFiles/PGS000886.txt.gz
PGS000888
(GLGC_2021_ALL_LDL_PRS_weights_PRS-CS)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 1,239,184
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000888/ScoringFiles/PGS000888.txt.gz
PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PGP000230 |
Graham SE et al. Nature (2021)
Low density lipoprotein (LDL) cholesterol low density lipoprotein cholesterol measurement 9,009
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000889/ScoringFiles/PGS000889.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002545 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001146|
African Ancestry|
3,566 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.125 age, sex, PC1-3
PPM002546 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001144|
African Ancestry|
4,273 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.114 age, sex, PC1-3
PPM002547 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001145|
African Ancestry|
707 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.067 age, sex, PC1-3
PPM002548 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001146|
African Ancestry|
3,566 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.123 age, sex, PC1-3
PPM002549 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001144|
African Ancestry|
4,273 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.052 age, sex, PC1-3
PPM002550 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001145|
African Ancestry|
707 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.063 age, sex, PC1-3
PPM002551 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001146|
African Ancestry|
3,566 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.055 age, sex, PC1-3
PPM002552 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001147|
African Ancestry|
10,460 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.173 age, sex, PC1-6
PPM002553 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001147|
African Ancestry|
10,460 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.122 age, sex, PC1-6
PPM002555 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001148|
African Ancestry|
1,745 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.069 age, sex, PC1-6
PPM002556 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001148|
African Ancestry|
1,745 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.041 age, sex, PC1-6
PPM002557 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001149|
African Ancestry|
4,972 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.128 age, sex, PC1-6
PPM002558 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001149|
African Ancestry|
4,972 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.108 age, sex, PC1-6
PPM002559 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001149|
African Ancestry|
4,972 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.04 age, sex, PC1-6
PPM002560 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001150|
African Ancestry|
3,743 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.076 age, sex, and PC1-4
PPM002561 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001150|
African Ancestry|
3,743 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.075 age, sex, and PC1-4
PPM002562 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001150|
African Ancestry|
3,743 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.022 age, sex, and PC1-4
PPM002563 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001151|
South Asian Ancestry|
15,242 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Max LDL cholesterol : 0.069 age, sex, and PC1-10
PPM002565 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001151|
South Asian Ancestry|
15,242 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Max LDL cholesterol : 0.096 age, sex, and PC1-10
PPM002566 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001151|
South Asian Ancestry|
15,242 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Max LDL cholesterol : 0.088 age, sex, and PC1-10
PPM002567 PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PSS001151|
South Asian Ancestry|
15,242 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Max LDL cholesterol : 0.077 age, sex, and PC1-10
PPM002568 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001152|
East Asian Ancestry|
118,260 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.051 age, sex, and recruitment area
PPM002569 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001152|
East Asian Ancestry|
118,260 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.095 age, sex, and recruitment area
PPM002570 PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PSS001152|
East Asian Ancestry|
118,260 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.098 age, sex, and recruitment area
PPM002571 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001152|
East Asian Ancestry|
118,260 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.094 age, sex, and recruitment area
PPM002573 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001152|
East Asian Ancestry|
118,260 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.064 age, sex, and recruitment area
PPM002574 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001153|
African Ancestry|
1,341 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.115 sex, batch, PC1-4, and birth year
PPM002575 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001154|
European Ancestry|
17,190 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.074 sex, batch, PC1-4, and birth year
PPM002576 PGS000886
(GLGC_2021_AFR_LDL_PRS_weights_PRS-CS)
PSS001153|
African Ancestry|
1,341 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.064 sex, batch, PC1-4, and birth year
PPM002578 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001153|
African Ancestry|
1,341 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.122 sex, batch, PC1-4, and birth year
PPM002579 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001154|
European Ancestry|
17,190 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.13 sex, batch, PC1-4, and birth year
PPM002580 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001153|
African Ancestry|
1,341 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.058 sex, batch, PC1-4, and birth year
PPM002581 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001154|
European Ancestry|
17,190 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.123 sex, batch, PC1-4, and birth year
PPM002582 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001153|
African Ancestry|
1,341 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.062 sex, batch, PC1-4, and birth year
PPM002583 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001154|
European Ancestry|
17,190 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.129 sex, batch, PC1-4, and birth year
PPM002584 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.148 sex, PC1-4, birth year, and mean age
PPM002585 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.063 sex, PC1-4, birth year, and mean age
PPM002587 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.071 sex, PC1-4, birth year, and mean age
PPM002588 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.162 sex, PC1-4, birth year, and mean age
PPM002589 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.1 sex, PC1-4, birth year, and mean age
PPM002590 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.158 sex, PC1-4, birth year, and mean age
PPM002591 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.134 sex, PC1-4, birth year, and mean age
PPM002592 PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.056 sex, PC1-4, birth year, and mean age
PPM002593 PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.098 sex, PC1-4, birth year, and mean age
PPM002594 PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.083 sex, PC1-4, birth year, and mean age
PPM002595 PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.057 sex, PC1-4, birth year, and mean age
PPM002596 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.041 sex, PC1-4, birth year, and mean age
PPM002598 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.083 sex, PC1-4, birth year, and mean age
PPM002599 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.063 sex, PC1-4, birth year, and mean age
PPM002600 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.042 sex, PC1-4, birth year, and mean age
PPM002601 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.066 sex, PC1-4, birth year, and mean age
PPM002602 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.152 sex, PC1-4, birth year, and mean age
PPM002603 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.106 sex, PC1-4, birth year, and mean age
PPM002604 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.04 sex, PC1-4, birth year, and mean age
PPM002605 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.067 sex, PC1-4, birth year, and mean age
PPM002606 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.153 sex, PC1-4, birth year, and mean age
PPM002607 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.114 sex, PC1-4, birth year, and mean age
PPM002609 PGS000895
(GLGC_2021_HIS_LDL_PRS_weights_PT)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.079 sex, PC1-4, birth year, and mean age
PPM002610 PGS000895
(GLGC_2021_HIS_LDL_PRS_weights_PT)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.119 sex, PC1-4, birth year, and mean age
PPM002611 PGS000895
(GLGC_2021_HIS_LDL_PRS_weights_PT)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.102 sex, PC1-4, birth year, and mean age
PPM002612 PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.076 sex, PC1-4, birth year, and mean age
PPM002613 PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.067 sex, PC1-4, birth year, and mean age
PPM002614 PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.101 sex, PC1-4, birth year, and mean age
PPM002615 PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PSS001159|
Hispanic or Latin American Ancestry|
7,669 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.069 sex, PC1-4, birth year, and mean age
PPM002616 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001160|
African Ancestry|
2,138 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.129 birth year, sex, and PC1-4
PPM002617 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001160|
African Ancestry|
2,138 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.132 birth year, sex, and PC1-4
PPM002618 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001160|
African Ancestry|
2,138 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.069 birth year, sex, and PC1-4
PPM002620 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001161|
East Asian Ancestry|
28,217 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.094 sex, age, recruitment method, and PC1-20
PPM002621 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001161|
East Asian Ancestry|
28,217 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.074 sex, age, recruitment method, and PC1-20
PPM002622 PGS000892
(GLGC_2021_EUR_LDL_PRS_weights_PRS-CS)
PSS001165|
European Ancestry|
389,158 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.182 sex, batch, age at initial assessment, PCs1-4
PPM002623 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001165|
European Ancestry|
389,158 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.176 sex, batch, age at initial assessment, PCs1-4
PPM002624 PGS000888
(GLGC_2021_ALL_LDL_PRS_weights_PRS-CS)
PSS001162|
Multi-ancestry (including European)|
461,918 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.175 sex, batch, age at initial assessment, PCs1-4
PPM002625 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001162|
Multi-ancestry (including European)|
461,918 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.182 sex, batch, age at initial assessment, PCs1-4
PPM002626 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001164|
East Asian Ancestry|
1,441 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.113 sex, batch, age at initial assessment, PCs1-4
PPM002627 PGS000891
(GLGC_2021_EAS_LDL_PRS_weights_PT)
PSS001164|
East Asian Ancestry|
1,441 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.1 sex, batch, age at initial assessment, PCs1-4
PPM002628 PGS000886
(GLGC_2021_AFR_LDL_PRS_weights_PRS-CS)
PSS001163|
African Ancestry|
6,863 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.112 sex, batch, age at initial assessment, PCs1-4
PPM002629 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001163|
African Ancestry|
6,863 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.175 sex, batch, age at initial assessment, PCs1-4
PPM002630 PGS000896
(GLGC_2021_SAS_LDL_PRS_weights_PRS-CS)
PSS001166|
South Asian Ancestry|
6,814 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.04 sex, batch, age at initial assessment, PCs1-4
PPM002631 PGS000897
(GLGC_2021_SAS_LDL_PRS_weights_PT)
PSS001166|
South Asian Ancestry|
6,814 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.058 sex, batch, age at initial assessment, PCs1-4
PPM002632 PGS000894
(GLGC_2021_HIS_LDL_PRS_weights_PRS-CS)
PSS001155|
Hispanic or Latin American Ancestry|
360 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.023 sex, batch, PC1-4, and birth year
PPM002633 PGS000895
(GLGC_2021_HIS_LDL_PRS_weights_PT)
PSS001155|
Hispanic or Latin American Ancestry|
360 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.088 sex, batch, PC1-4, and birth year
PPM002543 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001144|
African Ancestry|
4,273 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.118 age, sex, PC1-3
PPM002544 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001145|
African Ancestry|
707 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.101 age, sex, PC1-3
PPM002554 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001148|
African Ancestry|
1,745 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.085 age, sex, PC1-6
PPM002564 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001151|
South Asian Ancestry|
15,242 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Max LDL cholesterol : 0.105 age, sex, and PC1-10
PPM002572 PGS000893
(GLGC_2021_EUR_LDL_PRS_weights_PT)
PSS001152|
East Asian Ancestry|
118,260 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.071 age, sex, and recruitment area
PPM002577 PGS000886
(GLGC_2021_AFR_LDL_PRS_weights_PRS-CS)
PSS001154|
European Ancestry|
17,190 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.056 sex, batch, PC1-4, and birth year
PPM002586 PGS000887
(GLGC_2021_AFR_LDL_PRS_weights_PT)
PSS001158|
European Ancestry|
68,381 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.103 sex, PC1-4, birth year, and mean age
PPM002597 PGS000890
(GLGC_2021_EAS_LDL_PRS_weights_PRS-CS)
PSS001157|
Additional Asian Ancestries|
4,155 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.09 sex, PC1-4, birth year, and mean age
PPM002608 PGS000895
(GLGC_2021_HIS_LDL_PRS_weights_PT)
PSS001156|
African Ancestry|
18,251 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Mean LDL cholesterol : 0.1 sex, PC1-4, birth year, and mean age
PPM002619 PGS000889
(GLGC_2021_ALL_LDL_PRS_weights_PT)
PSS001161|
East Asian Ancestry|
28,217 individuals
PGP000230 |
Graham SE et al. Nature (2021)
Reported Trait: Baseline LDL cholesterol : 0.098 sex, age, recruitment method, and PC1-20

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001144 4,273 individuals African unspecified AADM
PSS001145 707 individuals African unspecified AADM
PSS001146 3,566 individuals African unspecified AADM
PSS001147 10,460 individuals African unspecified AWI-Gen
PSS001148 1,745 individuals African unspecified AWI-Gen
PSS001149 4,972 individuals Sub-Saharan African AWI-Gen
PSS001150 3,743 individuals African unspecified AWI-Gen
PSS001151 15,242 individuals South Asian G&H
PSS001152 118,260 individuals East Asian KoGES
PSS001153 1,341 individuals African American or Afro-Caribbean MGI
PSS001154 17,190 individuals European MGI
PSS001155 360 individuals Hispanic or Latin American MGI
PSS001156 18,251 individuals African American or Afro-Caribbean MVP Subset not used in discovery dataset
PSS001157 4,155 individuals Asian unspecified MVP Subset not used in discovery dataset
PSS001158 68,381 individuals European MVP Subset not used in discovery dataset
PSS001159 7,669 individuals Hispanic or Latin American MVP Subset not used in discovery dataset
PSS001160 2,138 individuals African American or Afro-Caribbean PMB
PSS001161 28,217 individuals East Asian ToMMo Only participants from Miyagi Prefecture were included
PSS001162 461,918 individuals European, African unspecified, East Asian, South Asian UKB
PSS001163 6,863 individuals African unspecified UKB
PSS001164 1,441 individuals East Asian UKB
PSS001165 389,158 individuals European UKB
PSS001166 6,814 individuals South Asian UKB