PGS Publication: PGP000233

Publication Information (EuropePMC)
Title Sex Differences in Genetic Risk for Hypertension.
PubMed ID 34397277(Europe PMC)
doi 10.1161/hypertensionaha.121.17796
Publication Date Aug. 15, 2021
Journal Hypertension
Author(s) Kauko A, Aittokallio J, Vaura F, Ji H, Ebinger JE, Niiranen T, Cheng S.
Released in PGS Catalog: Sept. 17, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000901
(PRS_SBP_m)
PGP000233 |
Kauko A et al. Hypertension (2021)
Systolic blood pressure (male) systolic blood pressure,
male
1,098,015
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000901/ScoringFiles/PGS000901.txt.gz
PGS000900
(PRS_SBP_f)
PGP000233 |
Kauko A et al. Hypertension (2021)
Systolic blood pressure (female) systolic blood pressure,
female
1,098,015
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000900/ScoringFiles/PGS000900.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002648 PGS000900
(PRS_SBP_f)
PSS001169|
European Ancestry|
123,579 individuals
PGP000233 |
Kauko A et al. Hypertension (2021)
Reported Trait: Hypertension HR: 1.42 [1.4, 1.44] Hazard Ratio (HR, top 2.5% vs middle 60%): 2.12 [1.99, 2.25] Age as timescale, collection year, genotyping batch, PCs(1-10)
PPM002649 PGS000901
(PRS_SBP_m)
PSS001170|
European Ancestry|
95,213 individuals
PGP000233 |
Kauko A et al. Hypertension (2021)
Reported Trait: Hypertension HR: 1.27 [1.26, 1.29] Hazard Ratio (HR, top 2.5% vs middle 60%): 1.8 [1.69, 1.92] Age as timescale, collection year, genotyping batch, PCs(1-10)
PPM002650 PGS000900
(PRS_SBP_f)
PSS001169|
European Ancestry|
123,579 individuals
PGP000233 |
Kauko A et al. Hypertension (2021)
Reported Trait: Early-onset hypertension (< 55 years) HR: 1.56 [1.53, 1.58] Hazard Ratio (HR, top 2.5% vs middle 60%): 2.51 [2.32, 2.72] Age as timescale, collection year, genotyping batch, PCs(1-10)
PPM002651 PGS000901
(PRS_SBP_m)
PSS001170|
European Ancestry|
95,213 individuals
PGP000233 |
Kauko A et al. Hypertension (2021)
Reported Trait: Early-onset hypertension (< 55 years) HR: 1.35 [1.32, 1.37] Hazard Ratio (HR, top 2.5% vs middle 60%): 2.1 [1.94, 2.28] Age as timescale, collection year, genotyping batch, PCs(1-10)
PPM002652 PGS000900
(PRS_SBP_f)
PSS001169|
European Ancestry|
123,579 individuals
PGP000233 |
Kauko A et al. Hypertension (2021)
Reported Trait: Late-onset hypertension (> 55 years) HR: 1.31 [1.28, 1.33] Hazard Ratio (HR, top 2.5% vs middle 60%): 1.66 [1.5, 1.84] Age as timescale, collection year, genotyping batch, PCs(1-10)
PPM002653 PGS000901
(PRS_SBP_m)
PSS001170|
European Ancestry|
95,213 individuals
PGP000233 |
Kauko A et al. Hypertension (2021)
Reported Trait: Late-onset hypertension (> 55 years) HR: 1.21 [1.19, 1.23] Hazard Ratio (HR, top 2.5% vs middle 60%): 1.45 [1.3, 1.61] Age as timescale, collection year, genotyping batch, PCs(1-10)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001169 Cases were individuals with hypertension. Of the 27,804 cases, 13,279 had early-onset hypertension (age of onset < 55 years) whilst 14,525 had late-onset hypertension (age of onset ≥ 55 years).
[
  • 27,804 cases
  • , 95,775 controls
]
,
0.0 % Male samples
European
(Finnish)
FinnGen
PSS001170 Cases were individuals with hypertension. Of the 28,113 cases, 14,082 had early-onset hypertension (age of onset < 55 years) whilst 14,031 had late-onset hypertension (age of onset ≥ 55 years).
[
  • 28,113 cases
  • , 67,100 controls
]
,
100.0 % Male samples
European
(Finnish)
FinnGen