PGS Publication: PGP000243

Publication Information (EuropePMC)
Title Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations.
PubMed ID 34662357(Europe PMC)
doi 10.1371/journal.pone.0258748
Publication Date Oct. 18, 2021
Journal PLoS One
Author(s) Borisevich D, Schnurr TM, Engelbrechtsen L, Rakitko A, Ängquist L, Ilinsky V, Aadahl M, Grarup N, Pedersen O, Sørensen TIA, Hansen T.
Released in PGS Catalog: Nov. 4, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000921
(PRS_BMI)
PGP000243 |
Borisevich D et al. PLoS One (2021)
Body mass index (BMI) body mass index 1,947,711
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000921/ScoringFiles/PGS000921.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002993 PGS000921
(PRS_BMI)
PSS001456|
European Ancestry|
5,179 individuals
PGP000243 |
Borisevich D et al. PLoS One (2021)
Reported Trait: Body mass index β: 1.7 kg/m2 : 0.162
R2 (linear regression BMI ~ 1 + PRS): 0.131
age, sex

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001456 5,179 individuals European
(Danish)
Inter99 Independent subset of Inter99, doesn't overlap with score development samples