PGS Publication: PGP000270

Publication Information (EuropePMC)
Title Blood Pressure Polygenic Scores Are Associated With Apparent Treatment-Resistant Hypertension.
PubMed ID 35522175(Europe PMC)
doi 10.1161/circgen.121.003554
Publication Date May 6, 2022
Journal Circ Genom Precis Med
Author(s) Breeyear JH, Shuey MM, Edwards TL, Hellwege JN.
Released in PGS Catalog: July 21, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002238
(SBP_PRS)
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Systolic blood pressure systolic blood pressure 1,119,444
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002238/ScoringFiles/PGS002238.txt.gz
PGS002239
(DBP_PRS)
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Diastolic blood pressure diastolic blood pressure 1,119,054
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002239/ScoringFiles/PGS002239.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012728 PGS002239
(DBP_PRS)
 PSS009510|
Ancestry Not Reported|
4,407 individuals
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Reported Trait: Apparent Treatment-Resistant Hypertension OR: 1.06 [1.01, 1.11] AUROC: 0.681 [0.669, 0.686] — age, age^2, bmi, sex, top 10 principal components of ancestry —
PPM012729 PGS002238
(SBP_PRS)
 PSS009511|
African Ancestry|
10,052 individuals
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Reported Trait: Apparent Treatment-Resistant Hypertension OR: 1.05 [0.95, 1.17] AUROC: 0.666 [0.637, 0.683] — age, age^2, bmi, sex, top 10 principal components of ancestry —
PPM012730 PGS002238
(SBP_PRS)
 PSS009512|
European Ancestry|
57,090 individuals
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Reported Trait: Apparent Treatment-Resistant Hypertension OR: 1.11 [1.06, 1.17] AUROC: 0.68 [0.669, 0.689] — age, age^2, bmi, sex, top 10 principal components of ancestry —
PPM012731 PGS002238
(SBP_PRS)
 PSS009510|
Ancestry Not Reported|
4,407 individuals
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Reported Trait: Apparent Treatment-Resistant Hypertension OR: 1.1 [1.05, 1.15] AUROC: 0.682 [0.67, 0.687] — age, age^2, bmi, sex, top 10 principal components of ancestry —
PPM012726 PGS002239
(DBP_PRS)
 PSS009511|
African Ancestry|
10,052 individuals
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Reported Trait: Apparent Treatment-Resistant Hypertension OR: 1.04 [0.94, 1.16] AUROC: 0.663 [0.644, 0.688] — age, age^2, bmi, sex, top 10 principal components of ancestry —
PPM012727 PGS002239
(DBP_PRS)
 PSS009512|
European Ancestry|
57,090 individuals
 PGP000270 |
Breeyear JH et al. Circ Genom Precis Med (2022)
 Reported Trait: Apparent Treatment-Resistant Hypertension OR: 1.05 [1.01, 1.11] AUROC: 0.679 — age, age^2, bmi, sex, top 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009511 Apparent Treatment-Resistant Hypertension —
[
  • 574 cases
  • , 4,452 controls
]
,
37.0 % Male samples
 Mean = 50.6 years African American or Afro-Caribbean African American, Non-Hispanic Black BioVU —
PSS009511 Apparent Treatment-Resistant Hypertension —
[
  • 574 cases
  • , 4,452 controls
]
,
37.0 % Male samples
 Mean = 50.6 years African American or Afro-Caribbean African American, Non-Hispanic Black BioVU Multi-Ancestry analysis
PSS009512 Apparent Treatment-Resistant Hypertension —
[
  • 2,961 cases
  • , 25,584 controls
]
,
46.0 % Male samples
 Mean = 58.58 years European European, Non-Hispanic White BioVU —
PSS009512 Apparent Treatment-Resistant Hypertension —
[
  • 2,961 cases
  • , 25,584 controls
]
,
46.0 % Male samples
 Mean = 58.58 years European European, Non-Hispanic White BioVU Multi-Ancestry analysis
PSS009510 Apparent Treatment-Resistant Hypertension —
[
  • 106 cases
  • , 4,301 controls
]
 — Not reported — BioVU Multi-Ancestry analysis