PGS Publication: PGP000276

Publication Information (EuropePMC)
Title Association of Lifestyle and Genetic Risk With Incidence of Dementia.
PubMed ID 31302669(Europe PMC)
doi 10.1001/jama.2019.9879
Publication Date Aug. 1, 2019
Journal JAMA
Author(s) Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ.
Released in PGS Catalog: Jan. 24, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002249
(AD_PRS_0.5)
PGP000276 |
Lourida I et al. JAMA (2019)
Alzheimer disease Alzheimer disease 249,273
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002249/ScoringFiles/PGS002249.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012797 PGS002249
(AD_PRS_0.5)
PSS009559|
European Ancestry|
196,383 individuals
PGP000276 |
Lourida I et al. JAMA (2019)
Reported Trait: Incident dementia Hazard Ratio (HR, high vs. low genetic risk): 1.91 [1.64, 2.23] Age, sex, education, socioeconomic status, relatedness, number of alleles, weighted lifestyle categories
PPM012798 PGS002249
(AD_PRS_0.5)
PSS009559|
European Ancestry|
196,383 individuals
PGP000276 |
Lourida I et al. JAMA (2019)
Reported Trait: Incident dementia in individuals with high genetic risk Incidence (%): 1.23 [1.13, 1.35]
Incidence (%, individuals with unfavourable lifestyle): 1.78 [1.38, 2.28]
Incidence (%, individuals with favourable lifestyle): 1.13 [1.01, 1.26]

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009559 AD: F00, F00.0, F00.1, F00.2, F00.9, G30, G30.0, G30.1, G30.8, G30.9 VaD: F01, F01.0, F01.1, F01.2, F01.3, F01.8, F01.9, I67.3 FTD: F02.0, G31.0, Other codes for all-cause dementia: A81.0, F02, F02.1, F02.2, F02.3, F02.4, F02.8, F03, F05.1, F10.6, G31.1, G31.8 Median = 8.0 years
[
  • 1,769 cases
  • , 194,614 controls
]
,
47.3 % Male samples
Mean = 64.1 years European UKB