PGS Publication: PGP000315

Publication Information (EuropePMC)
Title A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study.
PubMed ID 35387493(Europe PMC)
doi 10.1161/strokeaha.121.036551
Publication Date April 7, 2022
Journal Stroke
Author(s) Hämmerle M, Forer L, Schönherr S, Peters A, Grallert H, Kronenberg F, Gieger C, Lamina C.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000027 |
Abraham G et al. Nat Commun (2019)
Ischemic stroke stroke,
Ischemic stroke

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012987 PGS000039
European Ancestry|
3,071 individuals
PGP000315 |
Hämmerle M et al. Stroke (2022)
Reported Trait: Stroke Odds ratio (OR, top 1% vs. rest): 5.82 [2.08, 14.0] Age, sex, BMI, hypertension, cholesterol, diabetes, smoker

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009641 A stroke event was defined as hospitalization due to stroke which was self-reported in a structured and standardized inter- view performed by certified and supervised personnel. 3,071 individuals,
49.0 % Male samples
Mean = 57.4 years
Sd = 12.9 years
European KORA