PGS Publication: PGP000326

Publication Information (EuropePMC)
Title Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific Components.
PubMed ID 35252394(Europe PMC)
doi 10.3389/fcvm.2022.814502
Publication Date Feb. 16, 2022
Journal Front Cardiovasc Med
Author(s) Maj C, Salvi E, Citterio L, Borisov O, Simonini M, Glorioso V, Barlassina C, Glorioso N, Thijs L, Kuznetsova T, Cappuccio FP, Zhang ZY, Staessen JA, Cusi D, Lanzani C, Manunta P.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000326 |
Maj C et al. Front Cardiovasc Med (2022)
Hypertension hypertension 2,166

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013025 PGS002296
European Ancestry|
2,244 individuals
PGP000326 |
Maj C et al. Front Cardiovasc Med (2022)
Reported Trait: Hypertension OR: 3.22 [2.06, 5.1]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 1,284 cases
  • , 960 controls
61.0 % Male samples
European NR