PGS Publication: PGP000346

Publication Information (EuropePMC)
Title Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans.
PubMed ID 35790736(Europe PMC)
doi 10.1038/s41398-022-02029-2
Publication Date July 5, 2022
Journal Transl Psychiatry
Author(s) Lai D, Schwantes-An TH, Abreu M, Chan G, Hesselbrock V, Kamarajan C, Liu Y, Meyers JL, Nurnberger JI, Plawecki MH, Wetherill L, Schuckit M, Zhang P, Edenberg HJ, Porjesz B, Agrawal A, Foroud T.
Released in PGS Catalog: Aug. 3, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000346 |
Lai D et al. Transl Psychiatry (2022)
Alcohol use disorder alcohol dependence 858

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014842 PGS002739
African Ancestry|
6,315 individuals
PGP000346 |
Lai D et al. Transl Psychiatry (2022)
Reported Trait: Alcohol use disorder β: 0.17 (0.03) Odds Ratio (OR top 10% vs rest): 1.76 [1.32, 2.34]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 2,786 cases
  • , 3,529 controls
African American or Afro-Caribbean COGA, SAGE, Yale-Penn