PGS Publication: PGP000386

Publication Information (EuropePMC)
Title Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.
PubMed ID 36252120(Europe PMC)
doi 10.1161/circgen.122.003712
Publication Date Oct. 12, 2022
Journal Circ Genom Precis Med
Author(s) Saad M, El-Menyar A, Kunji K, Ullah E, Al Suwaidi J, Kullo IJ.
Released in PGS Catalog: Nov. 7, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000296
(GPS_CAD_SA)
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000296/ScoringFiles/PGS000296.txt.gz - Check Terms/Licenses
PGS000337
(MetaPRS_CAD)
PGP000104 |
Koyama S et al. Nat Genet (2020)
Coronary artery disease coronary artery disease 75,028
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000337/ScoringFiles/PGS000337.txt.gz - Check Terms/Licenses
PGS000018
(metaGRS_CAD)
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000749
(PRS_COMBINED)
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Coronary artery disease coronary artery disease 1,056,021
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000749/ScoringFiles/PGS000749.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015569 PGS000337
(MetaPRS_CAD)
PSS009986|
Greater Middle Eastern Ancestry|
7,023 individuals
PGP000386 |
Saad M et al. Circ Genom Precis Med (2022)
|Ext.
Reported Trait: Coronary heart disease OR: 1.81 [1.66, 1.98] AUROC: 0.667 [0.649, 0.685]
PPM015570 PGS000296
(GPS_CAD_SA)
PSS009986|
Greater Middle Eastern Ancestry|
7,023 individuals
PGP000386 |
Saad M et al. Circ Genom Precis Med (2022)
|Ext.
Reported Trait: Coronary heart disease OR: 1.53 [1.42, 1.64] AUROC: 0.683 [0.665, 0.701]
PPM015571 PGS000018
(metaGRS_CAD)
PSS009986|
Greater Middle Eastern Ancestry|
7,023 individuals
PGP000386 |
Saad M et al. Circ Genom Precis Med (2022)
|Ext.
Reported Trait: Coronary heart disease OR: 1.54 [1.43, 1.66] AUROC: 0.686 [0.667, 0.704]
PPM015572 PGS000749
(PRS_COMBINED)
PSS009986|
Greater Middle Eastern Ancestry|
7,023 individuals
PGP000386 |
Saad M et al. Circ Genom Precis Med (2022)
|Ext.
Reported Trait: Coronary heart disease OR: 1.66 [1.51, 1.82] AUROC: 0.645 [0.627, 0.663]

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009986
[
  • 1,014 cases
  • , 6,009 controls
]
,
47.0 % Male samples
Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB