PGS Publication: PGP000392

Publication Information (EuropePMC)
Title Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.
PubMed ID 36653681(Europe PMC)
doi 10.1038/s41588-022-01284-9
Publication Date Jan. 19, 2023
Journal Nat Genet
Author(s) Miyazawa K, Ito K, Ito M, Zou Z, Kubota M, Nomura S, Matsunaga H, Koyama S, Ieki H, Akiyama M, Koike Y, Kurosawa R, Yoshida H, Ozaki K, Onouchi Y, BioBank Japan Project, Takahashi A, Matsuda K, Murakami Y, Aburatani H, Kubo M, Momozawa Y, Terao C, Oki S, Akazawa H, Kamatani Y, Komuro I.
Released in PGS Catalog: Jan. 19, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
East Asian
South Asian
Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGP000392 |
Miyazawa K et al. Nat Genet (2023)
Atrial fibrillation atrial fibrillation 4,520

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015602 PGS002814
East Asian Ancestry|
24,147 individuals
PGP000392 |
Miyazawa K et al. Nat Genet (2023)
Reported Trait: Atrial fibrillation OR: 1.94332
β: 0.66
AUROC: 0.74 Nagelkerke’s pseudo R2: 0.14 age, sex, and the top 20 PCs We assessed the PRS performance using logistic regression model adjusted for covariates using glm in R.

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009995 ICD48
  • 2,953 cases
  • , 21,194 controls
East Asian