PGS Publication: PGP000396

Publication Information (EuropePMC)
Title Polygenic association of glomerular filtration rate decline in world trade center responders.
PubMed ID 36307804(Europe PMC)
doi 10.1186/s12882-022-02967-5
Publication Date Oct. 28, 2022
Journal BMC Nephrol
Author(s) Koraishy FM, Mann FD, Waszczuk MA, Kuan PF, Jonas K, Yang X, Docherty A, Shabalin A, Clouston S, Kotov R, Luft B.
Released in PGS Catalog: Nov. 23, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000664
(GRS7_GFR)
PGP000124 |
Gorski M et al. Kidney Int (2020)
Rapid decline of glomerular filtration rate (GFR) GFR change measurement 7
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000664/ScoringFiles/PGS000664.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016132 PGS000664
(GRS7_GFR)
PSS010042|
European Ancestry|
1,601 individuals
PGP000396 |
Koraishy FM et al. BMC Nephrol (2022)
|Ext.
Reported Trait: Chronic kidney disease stage OR: 1.18 [1.05, 1.32] Age, gender, education, the first ten genetic principal components, exposure severity
PPM016133 PGS000664
(GRS7_GFR)
PSS010042|
European Ancestry|
1,601 individuals
PGP000396 |
Koraishy FM et al. BMC Nephrol (2022)
|Ext.
Reported Trait: eGFR Decline (<= -1.00 ml/min/1.73m2/year) OR: 1.14 [1.01, 1.28] Age, gender, education, the first ten genetic principal components, exposure severity
PPM016131 PGS000664
(GRS7_GFR)
PSS010042|
European Ancestry|
1,601 individuals
PGP000396 |
Koraishy FM et al. BMC Nephrol (2022)
|Ext.
Reported Trait: Baseline eGFR β: -1.0 [-1.59, -0.41] Age, gender, education, the first ten genetic principal components, exposure severity

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010042 1,601 individuals,
93.0 % Male samples
Mean = 54.12 years European NR WTC