PGS Publication: PGP000399

Publication Information (EuropePMC)
Title Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals.
PubMed ID 35965108(Europe PMC)
doi 10.1016/j.biopsych.2022.06.004
Publication Date June 11, 2022
Journal Biol Psychiatry
Author(s) Fang Y, Fritsche LG, Mukherjee B, Sen S, Richmond-Rakerd LS.
Released in PGS Catalog: Dec. 6, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGP000399 |
Fang Y et al. Biol Psychiatry (2022)
Major Depressive Disorder major depressive disorder 1,088,415

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016144 PGS003333
European Ancestry|
34,703 individuals
PGP000399 |
Fang Y et al. Biol Psychiatry (2022)
Reported Trait: Major Depressive Disorder Nagelkerke pseudo-R2: 0.022

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010048 phecode 296.22
  • 13,850 cases
  • , 20,853 controls
European MGI