PGS Publication: PGP000409

Publication Information (EuropePMC)
Title Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
PubMed ID 36474045(Europe PMC)
doi 10.1038/s41588-022-01233-6
Publication Date Dec. 6, 2022
Journal Nat Genet
Author(s) Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC, Biobank Japan, EPIC-CVD, Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS, CARDIoGRAMplusC4D Consortium.
Released in PGS Catalog: Dec. 20, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS003355
(1MH_CAD_PRS_2015_Ldpred)
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Coronary artery disease coronary artery disease 1,532,758
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003355/ScoringFiles/PGS003355.txt.gz
PGS003356
(1MH_CAD_PRS_2022_Ldpred)
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Coronary artery disease coronary artery disease 2,324,683
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003356/ScoringFiles/PGS003356.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016211 PGS003356
(1MH_CAD_PRS_2022_Ldpred)
PSS010059|
European Ancestry|
14,298 individuals
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Reported Trait: Recurrent coronary artery disease HR: 1.2 [1.11, 1.29] age, sex and ancestry (PCs 1–5)
PPM016212 PGS003355
(1MH_CAD_PRS_2015_Ldpred)
PSS010059|
European Ancestry|
14,298 individuals
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Reported Trait: Recurrent coronary artery disease HR: 1.13 [1.04, 1.22] age, sex and ancestry (PCs 1–5)
PPM016208 PGS003356
(1MH_CAD_PRS_2022_Ldpred)
PSS010060|
Ancestry Not Reported|
5,685 individuals
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Reported Trait: Incident coronary artery disease HR: 1.61 [1.5, 1.72] age, sex and ancestry (PCs 1–5)
PPM016210 PGS003355
(1MH_CAD_PRS_2015_Ldpred)
PSS010060|
Ancestry Not Reported|
5,685 individuals
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Reported Trait: Incident coronary artery disease HR: 1.49 [1.39, 1.59] age, sex and ancestry (PCs 1–5)
PPM016209 PGS003356
(1MH_CAD_PRS_2022_Ldpred)
PSS010060|
Ancestry Not Reported|
5,685 individuals
PGP000409 |
Aragam KG et al. Nat Genet (2022)
Reported Trait: Incident coronary artery disease HR: 1.54 age, sex and ancestry (PCs 1–5), established risk factors for CAD (total cholesterol, HDL cholesterol, systolic blood pressure, body mass index, type 2 diabetes, current smoking status and family history of CAD)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010060
[
  • 815 cases
  • , 4,870 controls
]
,
41.0 % Male samples
Not reported MDC
PSS010059 Median = 2.3 years
[
  • 673 cases
  • , 13,625 controls
]
European FOURIER